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Chemical Compound Review

Deaza-Ado     2-(5-amino-4,7,9- triazabicyclo[4.3.0]nona...

Synonyms: CHEBI:120230, NSC-167897, AC1L1BXI, NSC167897, AR-1C5090, ...
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Disease relevance of Deaza-Ado


High impact information on Deaza-Ado


Chemical compound and disease context of Deaza-Ado


Biological context of Deaza-Ado


Anatomical context of Deaza-Ado


Associations of Deaza-Ado with other chemical compounds


Gene context of Deaza-Ado


Analytical, diagnostic and therapeutic context of Deaza-Ado


  1. Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains. Mayers, D.L., Mikovits, J.A., Joshi, B., Hewlett, I.K., Estrada, J.S., Wolfe, A.D., Garcia, G.E., Doctor, B.P., Burke, D.S., Gordon, R.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine. Sherman, M.L., Shafman, T.D., Spriggs, D.R., Kufe, D.W. Cancer Res. (1985) [Pubmed]
  3. Activation of collagen IV gene expression in F9 teratocarcinoma cells by 3-deazaadenosine analogs. Indirect inhibitors of methylation. Chiang, P.K., Burbelo, P.D., Brugh, S.A., Gordon, R.K., Fukuda, K., Yamada, Y. J. Biol. Chem. (1992) [Pubmed]
  4. Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli. Creedon, K.A., Rathod, P.K., Wellems, T.E. J. Biol. Chem. (1994) [Pubmed]
  5. Selective inhibition of avian sarcoma virus protein synthesis in 3-deazaadenosine-treated infected chicken embryo fibroblasts. Stoltzfus, C.M., Montgomery, J.A. J. Virol. (1981) [Pubmed]
  6. Transmethylation of phosphatidylethanolamine: an initial event in embryonic chicken lens fiber cell differentiation. Zelenka, P.S., Beebe, D.C., Feagans, D.E. Science (1982) [Pubmed]
  7. Conversion of 3T3-L1 fibroblasts to fat cells by an inhibitor of methylation: effect of 3-deazaadenosine. Chiang, P.K. Science (1981) [Pubmed]
  8. Perturbation of human endothelial cells by thrombin or PMA changes the reactivity of their extracellular matrix towards platelets. de Groot, P.G., Reinders, J.H., Sixma, J.J. J. Cell Biol. (1987) [Pubmed]
  9. 3-Deazaadenosine-induced disorganization of macrophage microfilaments. Stopford, C.R., Wolberg, G., Prus, K.L., Reynolds-Vaughn, R., Zimmerman, T.P. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  10. The methyltransferase inhibitor Neplanocin A interferes with influenza virus replication by a mechanism different from that of 3-deazaadenosine. Woyciniuk, P., Linder, M., Scholtissek, C. Virus Res. (1995) [Pubmed]
  11. Inhibitors of CDP-choline synthesis, action potential calcium channels, and stimulus-secretion coupling. de Blas, A., Adler, M., Shih, M., Chiang, P.K., Cantoni, G.L., Nirenberg, M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. Differential effects on growth, homocysteine, and related compounds of two inhibitors of S-adenosylhomocysteine catabolism, 3-deazaadenosine, and 3-deazaaristeromycin, in C3H/10T1/2 cells. Djurhuus, R., Svardal, A.M., Ueland, P.M. Cancer Res. (1989) [Pubmed]
  13. Regulatory role for the immune complex in modulation of phagocytosis by 3-deazaadenosine. Medzihradsky, J.L. J. Immunol. (1984) [Pubmed]
  14. Chemotaxis and the synthesis of specific proteins are inhibited by 3-deazaadenosine and other adenosine analogs in a mouse macrophage cell line. Aksamit, R.R., Backlund, P.S., Cantoni, G.L. J. Biol. Chem. (1983) [Pubmed]
  15. Differentiation of myoblast cell lines and biological methylation: 3-deazaadenosine stimulates formation of multinucleated myofibers. Scarpa, S., Strom, R., Bozzi, A., Aksamit, R.R., Backlund, P.S., Chen, J., Cantoni, G.L. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  16. Antagonism by taxol of effects of microtubule-disrupting agents on lymphocyte cAMP metabolism and cell function. Wolberg, G., Stopford, C.R., Zimmerman, T.P. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  17. Paradoxical effects of adenosine on neutrophil chemotaxis. Garcia-Castro, I., Mato, J.M., Vasanthakumar, G., Wiesmann, W.P., Schiffmann, E., Chiang, P.K. J. Biol. Chem. (1983) [Pubmed]
  18. Suppression of rat hepatoma cell growth by expression of phosphatidylethanolamine N-methyltransferase-2. Cui, Z., Houweling, M., Vance, D.E. J. Biol. Chem. (1994) [Pubmed]
  19. Biochemical analysis of initial triggering events of IgE-mediated histamine release from human lung mast cells. Ishizaka, T., Conrad, D.H., Schulman, E.S., Sterk, A.R., Ishizaka, K. J. Immunol. (1983) [Pubmed]
  20. Thrombin-induced release of von Willebrand factor from endothelial cells is mediated by phospholipid methylation. Prostacyclin synthesis is independent of phospholipid methylation. de Groot, P.G., Gonsalves, M.D., Loesberg, C., van Buul-Wortelboer, M.F., van Aken, W.G., van Mourik, J.A. J. Biol. Chem. (1984) [Pubmed]
  21. An epimer of 5'-noraristeromycin and its antiviral properties. Siddiqi, S.M., Chen, X., Schneller, S.W., Ikeda, S., Snoeck, R., Andrei, G., Balzarini, J., De Clercq, E. J. Med. Chem. (1994) [Pubmed]
  22. 3-deazaadenosine inhibits leukocyte adhesion and ICAM-1 biosynthesis in tumor necrosis factor-stimulated human endothelial cells. Jurgensen, C.H., Huber, B.E., Zimmerman, T.P., Wolberg, G. J. Immunol. (1990) [Pubmed]
  23. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. Jeong, S.Y., Ahn, S.G., Lee, J.H., Kim, H.S., Kim, J.W., Rhim, H., Jeong, S.W., Kim, I.K. J. Biol. Chem. (1999) [Pubmed]
  24. Effects of 3-deazaadenosine on homocysteine and atherosclerosis in apolipoprotein E-deficient mice. Langheinrich, A.C., Braun-Dullaeus, R.C., Walker, G., Jeide, I., Schilling, R., Tammoscheit, K., Dreyer, T., Fink, L., Bohle, R.M., Haberbosch, W. Atherosclerosis (2003) [Pubmed]
  25. Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target. Montgomery, J.A., Clayton, S.J., Thomas, H.J., Shannon, W.M., Arnett, G., Bodner, A.J., Kion, I.K., Cantoni, G.L., Chiang, P.K. J. Med. Chem. (1982) [Pubmed]
  26. Simultaneous myogenin expression and overall DNA hypomethylation promote in vitro myoblast differentiation. Scarpa, S., Lucarelli, M., Palitti, F., Carotti, D., Strom, R. Cell Growth Differ. (1996) [Pubmed]
  27. 3-Deazaadenosine prevents leukocyte invasion by suppression of adhesion molecule expression during acute cardiac allograft rejection: involvement of apoptotic cell death. Fingerhuth, H., Hölschermann, H., Grimm, H., Tillmanns, H., Haberbosch, W., Braun-Dullaeus, R.C., Stadlbauer, T.H. J. Heart Lung Transplant. (2004) [Pubmed]
  28. Failure to obtain drug-resistant variants of influenza virus after treatment with inhibiting doses of 3-deazaadenosine and H7. Scholtissek, C., Müller, K. Arch. Virol. (1991) [Pubmed]
  29. Stabilization of blood homocysteine in an epidemiological setting. Martín, I., Gibert, M.J., Vila, M., Pintos, C., Obrador, A., Malo, O. Eur. J. Cancer Prev. (2001) [Pubmed]
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