Disease relevance of AT 1902

• The nitrazine test results were affected by vaginal discharge but the PROM test results were not affected [1].
• The first principle, which is accepted by most, consists of searching for a positive history of PROM, confirming PROM (by speculum examination, pooling, positive Nitrazine testing, and ferning), and obtaining cervical and vaginal cultures (for group B streptococcus/gonococcus and chlamydia) [2].

High impact information on AT 1902

• We compared this improved AFP test with the nitrazine test for 137 patients [3].
• The nitrazine test showed a specificity of 58.3%, whereas the AFP kit showed a 100% rate for detecting > or = 37 weeks of gestation (P < 0.01) [3].
• PPROM patients had documented confirmatory tests, including visualized pooling of amniotic fluid in the vaginal vault that was nitrazine-positive and demonstrated ferning [4].
• In problematic cases, the nitrazine and fern tests can be used to confirm the diagnosis [5].
• METHODS: In a multicenter clinical trial, pooling, ferning, and nitrazine tests were compared with fetal fibronectin in 339 women at term (study group) with a clinical history of rupture of the membranes and in 67 women at term receiving routine prenatal care (controls) [6].

Biological context of AT 1902

• The nitrazine test correctly diagnosed 62.1% of the cases, but the improved AFP kit diagnosed 98.0% for < 37 weeks of gestation (P < 0.001) [3].

Anatomical context of AT 1902

• "Fig leaf" ferning and positive Nitrazine testing: semen as a cause of misdiagnosis of premature rupture of membranes [7].
• The result of the AL-SENSE strip test was compared with the clinical diagnosis, which was based on direct visualization of the posterior vaginal fornix and cervix, crystallization, and nitrazine tests [8].
• Most studies investigating the usefulness of ferning and nitrazine methods for detecting the presence of amniotic fluid following ruptured amniotic membranes have employed samples from vaginal pooling [9].

Associations of AT 1902 with other chemical compounds

• After she later complained of fluid leakage, a premature rupture of the membranes (PROM) was suspected, because of positive results on a test for nitrazine, the intra-amniotic dye injection method (PSP test), and an AFP-kit test at 22 weeks of gestation [10].

Gene context of AT 1902

• Significance of detecting insulin-like growth factor binding protein-1 in cervicovaginal secretions: comparison with nitrazine test and amniotic fluid volume assessment [1].
• RESULTS: The ROM-check and nitrazine tests showed a diagnostic accuracy of 89.1 and 87.0%, respectively, compared with 95.7% with the improved AFP test [11].
• The nitrazine and PSP tests later turned negative [10].

References