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Chemical Compound Review

AG-K-66186     2-methyl-2-methylamino- propanoic acid

Synonyms: CHEMBL1916079, M2383_SIGMA, HMDB02141, AC1L2PDY, AC1Q5SKM, ...
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Disease relevance of EINECS 219-898-2


High impact information on EINECS 219-898-2


Biological context of EINECS 219-898-2


Anatomical context of EINECS 219-898-2

  • When transport polarity was assessed in confluent polarized epithelial cell monolayers cultured on Nucleopore filters and mounted between two lucite chambers, Na+-stimulated transport of 2-(methylamino)isobutyric acid (MeAIB), a substrate specific for the A system, was predominantly localized on the basolateral membrane [8].

Associations of EINECS 219-898-2 with other chemical compounds


  1. Alteration of amino acid transport by hydrocortisone. Different effects in human fibroblasts derived from normal skin and keloid. Russell, S.B., Russell, J.D., Trupin, J.S. J. Biol. Chem. (1982) [Pubmed]
  2. Simultaneous regulation of amino acid influx and efflux by system A in the hepatoma cell HTC. Ouabain simulates the starvation-induced derepression of system A amino acid transport. White, M.F., Christensen, H.N. J. Biol. Chem. (1983) [Pubmed]
  3. Characterization of sodium-dependent amino acid transport activity during liver regeneration. Fowler, F.C., Banks, R.K., Mailliard, M.E. Hepatology (1992) [Pubmed]
  4. Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin. Su, T.Z., Wang, M., Syu, L.J., Saltiel, A.R., Oxender, D.L. J. Biol. Chem. (1998) [Pubmed]
  5. Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporters. Kong, C.T., Yet, S.F., Lever, J.E. J. Biol. Chem. (1993) [Pubmed]
  6. Vanadate stimulates system A amino acid transport activity in skeletal muscle. Evidence for the involvement of intracellular pH as a mediator of vanadate action. Muñoz, P., Gumà, A., Camps, M., Furriols, M., Testar, X., Palacín, M., Zorzano, A. J. Biol. Chem. (1992) [Pubmed]
  7. Physiological importance of system A-mediated amino acid transport to rat fetal development. Cramer, S., Beveridge, M., Kilberg, M., Novak, D. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  8. Amino acid transport in kidney epithelial cell line (MDCK): characteristics of Na+/amino acid symport in membrane vesicles and basolateral localization in cell monolayers. Lever, J.E., Kennedy, B.G., Vasan, R. Arch. Biochem. Biophys. (1984) [Pubmed]
  9. Hormone-induced system A amino acid transport activity in rat liver plasma membrane and Golgi vesicles. Evidence for a differential sensitivity to inactivation by N-ethylmaleimide during carrier maturation. Cariappa, R., Kilberg, M.S. J. Biol. Chem. (1990) [Pubmed]
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