The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC5A4  -  solute carrier family 5 (glucose activated...

Homo sapiens

Synonyms: DJ90G24.4, Low affinity sodium-glucose cotransporter, Na(+)/glucose cotransporter 3, SAAT1, SGLT2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SLC5A4


High impact information on SLC5A4

  • We have examined the expression and function of a previously undescribed human member (SGLT3/SLC5A4) of the sodium/glucose cotransporter gene family (SLC5) that was first identified by the chromosome 22 genome project [2].
  • Functional studies using the Xenopus laevis oocyte expression system showed that hSGLT3 was incapable of sugar transport, even though SGLT3 was efficiently inserted into the plasma membrane [2].
  • Transport of beta-D-Glc-IPM and glucose by SAAT1 is apparently performed by the same mechanism because similar sodium dependence, dependence on membrane potential, electrogenicity, and phlorizin inhibition were determined for beta-D-Glc-IPM, D-glucose, and AMG [1].
  • Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1 [1].
  • A leucine zipper region was detected in both SAAT1 and SGLT1 [3].

Biological context of SLC5A4


Anatomical context of SLC5A4

  • The message for SAAT1 was a single 2.4-kilobase species in kidney, but mRNA species of 2.4 and 3.7 kilobases were observed in LLC-PK1 cells as well as in intestine [3].
  • Expression of SAAT1 in COS-7 cells resulted in increased levels of Na(+)-dependent uptake of 2-(methylamino)isobutyric acid, a specific substrate for the system A amino acid transporter [3].
  • African American children had higher insulin concentrations than white children after total body fat, IAAT, and SAAT were controlled for [4].
  • We examined the association between the Ala(54)Thr variant in the FABP2 gene and levels of visceral (VAT) and sc (SAAT) abdominal fat in a group of 223 premenopausal African-American (n = 103) and Caucasian (n = 120) women [8].
  • Fasting and postchallenge insulin concentrations were determined by oral-glucose-tolerance test, total body fat by dual-energy X-ray absorptiometry, and subcutaneous abdominal (SAAT) and intraabdominal (IAAT) adipose tissue by computerized tomography [4].

Associations of SLC5A4 with chemical compounds


Other interactions of SLC5A4

  • Skeletal muscle hSGLT3 and GLUT4 mRNA transcript levels were determined by real time RT-PCR. hSGLT3 transcripts increased by a factor of ten following resistance training compared to control subjects (0.10, P=0.03) [7].

Analytical, diagnostic and therapeutic context of SLC5A4


  1. Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1. Veyhl, M., Wagner, K., Volk, C., Gorboulev, V., Baumgarten, K., Weber, W.M., Schaper, M., Bertram, B., Wiessler, M., Koepsell, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. A glucose sensor hiding in a family of transporters. Diez-Sampedro, A., Hirayama, B.A., Osswald, C., Gorboulev, V., Baumgarten, K., Volk, C., Wright, E.M., Koepsell, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporters. Kong, C.T., Yet, S.F., Lever, J.E. J. Biol. Chem. (1993) [Pubmed]
  4. Fat distribution and insulin response in prepubertal African American and white children. Gower, B.A., Nagy, T.R., Trowbridge, C.A., Dezenberg, C., Goran, M.I. Am. J. Clin. Nutr. (1998) [Pubmed]
  5. Imino sugars are potent agonists of the human glucose sensor SGLT3. Voss, A.A., Díez-Sampedro, A., Hirayama, B.A., Loo, D.D., Wright, E.M. Mol. Pharmacol. (2007) [Pubmed]
  6. Na+-to-sugar stoichiometry of SGLT3. Díez-Sampedro, A., Eskandari, S., Wright, E.M., Hirayama, B.A. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  7. Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance training. Castaneda, F., Layne, J.E., Castaneda, C. International journal of medical sciences [electronic resource]. (2006) [Pubmed]
  8. Association of the intestinal fatty acid-binding protein Ala54Thr polymorphism and abdominal adipose tissue in African-American and Caucasian women. Lara-Castro, C., Hunter, G.R., Lovejoy, J.C., Gower, B.A., Fernández, J.R. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  9. Luminal glucose sensing in the rat intestine has characteristics of a sodium-glucose cotransporter. Freeman, S.L., Bohan, D., Darcel, N., Raybould, H.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  10. Adipose tissue distribution in obese females. Relationship to androgens, cortisol, growth hormone and leptin. Kunesová, M., Hainer, V., Obenberger, J., Mikulová, R., Parízková, J., Slabá, S., Bezdícková, D., Seidl, Z. Sborník lékar̆ský. (2002) [Pubmed]
  11. Ex vivo responsiveness of head and neck squamous cell carcinoma to glufosfamide, a novel alkylating agent. Dollner, R., Dietz, A., Kopun, M., Helbig, M., Wallner, F., Granzow, C. Anticancer Res. (2004) [Pubmed]
WikiGenes - Universities