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Chemical Compound Review

Selenocyanate     selenocyanate

Synonyms: CHEBI:29445, AR-1L4101, FT-0695273, AC1L2S1X, AC1Q230D, ...
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Disease relevance of selenocyanate


High impact information on selenocyanate

  • The loss of proton coupling to these anions is accompanied by an absence of bound anions in the central and external Cl(-) binding sites in the protein's anion selectivity region, as revealed by crystallographic comparison of Br(-) and SeCN(-) bound to this region [3].
  • The interaction of SeH or SeCN groups with the vinyl group has been investigated with UV photoelectron spectroscopy and quantum chemical calculations, using the MP2/cc-pVTZ and B3LYP/cc-pVTZ levels [4].
  • The luminescence properties of thiocyanate and selenocyanate platinum(II) and palladium(II) complexes show strong variations with temperature and pressure [5].
  • In the present study, a synthetic organoselenium compound diphenylmethyl selenocyanate was evaluated for its ability to arrest cell proliferation and to induce apoptosis against 7,12-dimethylbenz[a]anthracene-croton oil induced two-stage mouse skin carcinogenesis model [6].
  • Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation [6].

Biological context of selenocyanate


Associations of selenocyanate with other chemical compounds

  • In the present study, antioxidative and chemopreventive properties of a synthetic organoselenium compound, diphenylmethyl selenocyanate, were evaluated with a 7,12-dimethylbenz (a) anthracene - croton oil induced two-stage mouse skin carcinogenesis model [8].
  • Dye-sensitized mesoporous nanocrystalline SnO2 electrodes and the pseudohalogen redox mediator (SeCN)2/SeCN- or (SCN)2/SCN- or the halogen redox mediator I3-/I- were implemented for regenerative solar cell studies [9].

Gene context of selenocyanate


Analytical, diagnostic and therapeutic context of selenocyanate


  1. Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. Narayanan, B.A., Narayanan, N.K., Desai, D., Pittman, B., Reddy, B.S. Carcinogenesis (2004) [Pubmed]
  2. Nutritional availability and chronic toxicity of selenocyanate in the rat. Vadhanavikit, S., Ganther, H.E. J. Nutr. (1988) [Pubmed]
  3. Uncoupling of a CLC Cl(-)/H(+) Exchange Transporter by Polyatomic Anions. Nguitragool, W., Miller, C. J. Mol. Biol. (2006) [Pubmed]
  4. Alkenyl selenols and selenocyanates: synthesis, spectroscopic characterization by photoelectron spectroscopy, and quantum chemical study. Bajor, G., Veszprémi, T., Riague, e.l. .H., Guillemin, J.C. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  5. Pressure-induced enhancements of luminescence intensities and lifetimes correlated with emitting-state distortions for thiocyanate and selenocyanate complexes of platinum(II) and palladium(II). Grey, J.K., Butler, I.S., Reber, C. Inorganic chemistry. (2003) [Pubmed]
  6. Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. Das, R.K., Hossain, S.K., Bhattacharya, S. Cancer Lett. (2005) [Pubmed]
  7. Inhibition of DMBA/croton oil-induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate. Das, R.K., Ghosh, S., Sengupta, A., Das, S., Bhattacharya, S. Eur. J. Cancer Prev. (2004) [Pubmed]
  8. Inhibition of DMBA-croton oil two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate through modulation of cutaneous oxidative stress and inhibition of nitric oxide production. Das, R.K., Bhattacharya, S. Asian Pac. J. Cancer Prev. (2004) [Pubmed]
  9. Dye-sensitized SnO2 electrodes with iodide and pseudohalide redox mediators. Bergeron, B.V., Marton, A., Oskam, G., Meyer, G.J. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  10. Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride-induced hepatotoxicity in vivo. Das, R.K., Das, S., Bhattacharya, S. J. Environ. Pathol. Toxicol. Oncol. (2004) [Pubmed]
  11. Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention. Ip, C., el-Bayoumy, K., Upadhyaya, P., Ganther, H., Vadhanavikit, S., Thompson, H. Carcinogenesis (1994) [Pubmed]
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