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Chemical Compound Review

Fapygua     N-(2,4-diamino-6-oxo-5H- pyrimidin-5...

Synonyms: Fapy-G, Fapy guanine, CHEBI:29145, AC1L3UE7, 2,6-Diamino-4-oxo-5-formamidopyrimidine
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Disease relevance of Fapy-G


High impact information on Fapy-G


Anatomical context of Fapy-G

  • When human respiratory tract epithelial cells were exposed to 100 microM H2O2, there was rapid induction of DNA strand breakage and chemical modifications to all 4 DNA bases suggestive of attack by OH.. The major products were FAPy-adenine, FAPy-guanine, and 8-OH-guanine [7].

Associations of Fapy-G with other chemical compounds


Gene context of Fapy-G


  1. Formation of 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine in DNA by riboflavin mediated photosensitization. Mori, T., Tano, K., Takimoto, K., Utsumi, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  2. Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. Hu, J., de Souza-Pinto, N.C., Haraguchi, K., Hogue, B.A., Jaruga, P., Greenberg, M.M., Dizdaroglu, M., Bohr, V.A. J. Biol. Chem. (2005) [Pubmed]
  3. Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase. Coste, F., Ober, M., Carell, T., Boiteux, S., Zelwer, C., Castaing, B. J. Biol. Chem. (2004) [Pubmed]
  4. Characterization and mechanism of action of Drosophila ribosomal protein S3 DNA glycosylase activity for the removal of oxidatively damaged DNA bases. Deutsch, W.A., Yacoub, A., Jaruga, P., Zastawny, T.H., Dizdaroglu, M. J. Biol. Chem. (1997) [Pubmed]
  5. Base pairing and replicative processing of the formamidopyrimidine-dG DNA lesion. Ober, M., Müller, H., Pieck, C., Gierlich, J., Carell, T. J. Am. Chem. Soc. (2005) [Pubmed]
  6. Arabidopsis thaliana Ogg1 protein excises 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from oxidatively damaged DNA containing multiple lesions. Morales-Ruiz, T., Birincioglu, M., Jaruga, P., Rodriguez, H., Roldan-Arjona, T., Dizdaroglu, M. Biochemistry (2003) [Pubmed]
  7. Oxidative DNA damage in human respiratory tract epithelial cells. Time course in relation to DNA strand breakage. Spencer, J.P., Jenner, A., Aruoma, O.I., Cross, C.E., Wu, R., Halliwell, B. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  8. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Boiteux, S., Gajewski, E., Laval, J., Dizdaroglu, M. Biochemistry (1992) [Pubmed]
  9. Radiation-induced DNA damage as a function of hydration. II. Base damage from electron-loss centers. Swarts, S.G., Becker, D., Sevilla, M., Wheeler, K.T. Radiat. Res. (1996) [Pubmed]
  10. Loss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo. Whiteman, M., Hong, H.S., Jenner, A., Halliwell, B. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations. Dherin, C., Radicella, J.P., Dizdaroglu, M., Boiteux, S. Nucleic Acids Res. (1999) [Pubmed]
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