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Chemical Compound Review

GLYOXAL     ethanedial

Synonyms: Biformal, Biformyl, Diformal, Diformyl, Ethanedial, ...
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Disease relevance of ethanedial

  • Oxypolygelatine is commercially available for clinical use as a plasma expander, is 30-fold less expensive than human serum albumin, is certified free of foreign serum proteins and antibodies as well as free of pyrogen, viral, mycoplasmal and bovine spongiform encephalopathy contaminants [1].
  • OBJECTIVE/METHODS: The pharmacokinetics of the plasma substitute oxypolygelatine (OPG) were studied in 12 healthy volunteers after single-dose administration of 27 ml x kg(-1) body weight, with a maximum of 2000 ml [2].

High impact information on ethanedial

  • The total initiating doses were 200 mumol for LG-I and DG, 25 mumol for LG-II and 500 mumol for FF, HMF, GL, MGL and TZ [3].
  • The effects of 4% plasma protein solution (group P), 6% dextran-70 (group D), and 5.5% oxypolygelatin (group G) on plasma volume and hemodynamics were compared with each other and with controls (group C) who received only maintenance infusion 20 h after coronary bypass surgery [4].
  • Benefits of blood cell transplant cryopreservation with oxypolygelatine (Gelifundol) plasma substitute [1].
  • A commercially available plasma expander (Gelifundol) containing 5.5% oxypolygelatine in buffered saline was used instead of serum as a supplement for freezing several types of human cell and a mouse myeloma cell line in liquid nitrogen [5].
  • It is suggested that the reaction potentialities of the oxaldehyde function of the inhibitors play an important role in their growth-inhibitory activity, besides exerting a specific effect on hexokinase (glucosone) and UTP-trapping activity [6].

Biological context of ethanedial


Anatomical context of ethanedial


Associations of ethanedial with other chemical compounds

  • In conjunction with promotion TZ induced skin tumors in 40% of the mice (average 0.65 tumors/mouse), FF in 25% (0.40/mouse), LG-I in 25% (0.35/mouse) and LG-II, HMF, DG and GL in 10-20% (0.11-0.25/mouse) respectively whereas DMBA induced skin tumors in 100% of the animals (6.7/mouse) [3].

Analytical, diagnostic and therapeutic context of ethanedial


  1. Benefits of blood cell transplant cryopreservation with oxypolygelatine (Gelifundol) plasma substitute. Di Nicola, M., Siena, S., Bregni, M., Belli, N., Milanesi, M., Ruffini, P.A., Malaffo, F., Ravagnani, F., Gianni, A.M. Bone Marrow Transplant. (1996) [Pubmed]
  2. Pharmacokinetics of oxypolygelatine in healthy volunteers. Thürmann, P.A., Lissner, R., Struff, W.G., Harder, S. Eur. J. Clin. Pharmacol. (1999) [Pubmed]
  3. Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model. Miyakawa, Y., Nishi, Y., Kato, K., Sato, H., Takahashi, M., Hayashi, Y. Carcinogenesis (1991) [Pubmed]
  4. Effects of three colloid solutions on plasma volume and hemodynamics after coronary bypass surgery. Karanko, M.S. Crit. Care Med. (1987) [Pubmed]
  5. Freezing of cells--replacement of serum by oxypolygelatine. Groth, J., Steinmann, J., Eckstein, V., Müller-Ruchholtz, W. J. Immunol. Methods (1991) [Pubmed]
  6. A comparative study on proliferation, macromolecular synthesis and energy metabolism of in vitro-grown Ehrlich ascites tumor cells in the presence of glucosone, galactosone and methylglyoxal. Reiffen, K.A., Schneider, F. J. Cancer Res. Clin. Oncol. (1984) [Pubmed]
  7. Assessment of successful valve reconstruction by intraoperative transesophageal echocardiography (TEE). Drexler, M., Erbel, R., Dahm, M., Mohr-Kahaly, S., Oelert, H., Meyer, J. International journal of cardiac imaging. (1986) [Pubmed]
  8. Optimized transcranial Doppler technique for the diagnosis of cardiac right-to-left shunts. Albert, A., Müller, H.R., Hetzel, A. Journal of neuroimaging : official journal of the American Society of Neuroimaging. (1997) [Pubmed]
  9. Stroke volume variations for assessment of cardiac responsiveness to volume loading in mechanically ventilated patients after cardiac surgery. Reuter, D.A., Felbinger, T.W., Schmidt, C., Kilger, E., Goedje, O., Lamm, P., Goetz, A.E. Intensive care medicine. (2002) [Pubmed]
  10. Evaluation studies on oxypolygelatin and degraded gelatin as plasma volume expanders. Gabr, Y.A., Assem, N.M., Micheal, A.B., Fahmy, L.H. Arzneimittel-Forschung. (1996) [Pubmed]
  11. Viscosity measurements for LEH suspended in different plasma expanders. Chung, T.W., Wang, J.F. Artificial cells, blood substitutes, and immobilization biotechnology. (1997) [Pubmed]
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