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MeSH Review

Microbubbles

 
 
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Disease relevance of Microbubbles

 

High impact information on Microbubbles

  • METHODS: An image-enhancing ultrasound (US) contrast agent, consisting of encapsulated gaseous microbubbles (MB), was developed specifically to bind mucosal addressin cellular adhesion molecule-1 (MAdCAM-1), a mucosal-restricted addressin up-regulated during gut inflammation [6].
  • We tested a new microbubble designed to bind to and allow specific ultrasound detection of intercellular adhesion molecule-1 (ICAM-1) [7].
  • The synthesis of aqueous suspensions of air-filled proteinaceous microbubbles involves the ultrasonic irradiation of aqueous protein solutions in the presence of O2 [8].
  • The microbubbles are held together primarily by interprotein cross-linking of cysteine residues [8].
  • Five milliliters of dextrose or saline are injected into the appropriate cardiac chamber, generating echogenic microbubbles (contrast) that normally exit in an antegrade direction, but reflux retrograde in the presence of valvular regurgitation [9].
 

Chemical compound and disease context of Microbubbles

 

Biological context of Microbubbles

 

Anatomical context of Microbubbles

 

Associations of Microbubbles with chemical compounds

  • Microbubbles were conjugated to cyclic peptides containing either RRL (RRL-MB) or a glycine control sequence (control-MB) [25].
  • At baseline and after insulin infusion, MBV and MFV were measured by CEU during continuous intravenous infusion of albumin microbubbles with intermittent harmonic ultrasound imaging of the forearm deep flexor muscles [26].
  • Pulse inversion Doppler imaging was performed in 117 patients during dobutamine stress echocardiography by using an intravenous bolus of a perfluorocarbon-filled, albumin-(Optison: n = 98) or liposome- (Definity: n = 19) encapsulated microbubble and a mechanical index of <0 [27].
  • Two microbubble sizes were obtained by sonicating Renografin-76 (meglumine sodium diatrizoate): mean diameter 12 +/- 3 (SEE) and 20 +/- 6 micron [28].
  • It is concluded that of the contrast agents examined, sonicated solutions of sorbitol (70%) and dextrose (70%) appeared to have particular potential because of the small sizes of the microbubbles (6 +/- 2 and 8 +/- 3 mu, respectively) and their prolonged in vitro persistence [29].
 

Gene context of Microbubbles

 

Analytical, diagnostic and therapeutic context of Microbubbles

References

  1. Treatment of acute myocardial infarction by hepatocyte growth factor gene transfer: the first demonstration of myocardial transfer of a "functional" gene using ultrasonic microbubble destruction. Kondo, I., Ohmori, K., Oshita, A., Takeuchi, H., Fuke, S., Shinomiya, K., Noma, T., Namba, T., Kohno, M. J. Am. Coll. Cardiol. (2004) [Pubmed]
  2. Hepatocellular carcinoma in adenomatous hyperplasia: detection with contrast-enhanced US with carbon dioxide microbubbles. Nomura, Y., Matsuda, Y., Yabuuchi, I., Nishioka, M., Tarui, S. Radiology. (1993) [Pubmed]
  3. Increase in capillary perfusion following low-intensity ultrasound and microbubbles during postischemic reperfusion. Bertuglia, S. Crit. Care Med. (2005) [Pubmed]
  4. Evaluation of metastases and reactive lymph nodes in Doppler sonography using an ultrasound contrast enhancer. Mäurer, J., Willam, C., Schroeder, R., Hidajad, N., Hell, B., Bier, J., Weber, S., Felix, R. Investigative radiology. (1997) [Pubmed]
  5. Clinical safety of SonoVue, a new contrast agent for ultrasound imaging, in healthy volunteers and in patients with chronic obstructive pulmonary disease. Bokor, D., Chambers, J.B., Rees, P.J., Mant, T.G., Luzzani, F., Spinazzi, A. Investigative radiology. (2001) [Pubmed]
  6. Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease. Bachmann, C., Klibanov, A.L., Olson, T.S., Sonnenschein, J.R., Rivera-Nieves, J., Cominelli, F., Ley, K.F., Lindner, J.R., Pizarro, T.T. Gastroenterology (2006) [Pubmed]
  7. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Villanueva, F.S., Jankowski, R.J., Klibanov, S., Pina, M.L., Alber, S.M., Watkins, S.C., Brandenburger, G.H., Wagner, W.R. Circulation (1998) [Pubmed]
  8. Air-filled proteinaceous microbubbles: synthesis of an echo-contrast agent. Grinstaff, M.W., Suslick, K.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  9. Intraoperative echocardiography for the evaluation of valvular regurgitation: experience in 263 patients. Goldman, M.E., Fuster, V., Guarino, T., Mindich, B.P. Circulation (1986) [Pubmed]
  10. The clinical implications of no reflow demonstrated with intravenous perfluorocarbon containing microbubbles following restoration of Thrombolysis In Myocardial Infarction (TIMI) 3 flow in patients with acute myocardial infarction. Porter, T.R., Li, S., Oster, R., Deligonul, U. Am. J. Cardiol. (1998) [Pubmed]
  11. Effect of phospholipid-coated microbubbles (MRX-115) on the detection of testicular ischemia in dogs. Metzger-Rose, C., Wright, W.H., Baker, M.R., Krupinski, E.A., McCreery, T.P., Barrette, T.R., Unger, E.C. Academic radiology. (1996) [Pubmed]
  12. Novel site-specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model. Kipshidze, N.N., Porter, T.R., Dangas, G., Yazdi, H., Tio, F., Xie, F., Hellinga, D., Wolfram, R., Seabron, R., Waksman, R., Abizaid, A., Roubin, G., Iyer, S., Colombo, A., Leon, M.B., Moses, J.W., Iversen, P. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2005) [Pubmed]
  13. Preparation of human hepatocellular carcinoma-targeted liposome microbubbles and their immunological properties. Bian, A.N., Gao, Y.H., Tan, K.B., Liu, P., Zeng, G.J., Zhang, X., Liu, Z. World J. Gastroenterol. (2004) [Pubmed]
  14. Enhancement of ultrasound-accelerated thrombolysis by echo contrast agents: dependence on microbubble structure. Mizushige, K., Kondo, I., Ohmori, K., Hirao, K., Matsuo, H. Ultrasound in medicine & biology. (1999) [Pubmed]
  15. An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney. Koike, H., Tomita, N., Azuma, H., Taniyama, Y., Yamasaki, K., Kunugiza, Y., Tachibana, K., Ogihara, T., Morishita, R. The journal of gene medicine. (2005) [Pubmed]
  16. Microbubble-induced phospholipase C activation does not correlate with platelet aggregation. Malmgren, R., Thorsen, T., Nordvik, A., Holmsen, H. Thromb. Haemost. (1993) [Pubmed]
  17. Human pharmacokinetics and safety evaluation of SonoVue, a new contrast agent for ultrasound imaging. Morel, D.R., Schwieger, I., Hohn, L., Terrettaz, J., Llull, J.B., Cornioley, Y.A., Schneider, M. Investigative radiology. (2000) [Pubmed]
  18. Assessment of regional myocardial perfusion with myocardial contrast echocardiography in a canine model of varying degrees of coronary stenosis. Desir, R.M., Cheirif, J., Bolli, R., Zoghbi, W.A., Hoyt, B.D., Quiñones, M.A. Am. Heart J. (1994) [Pubmed]
  19. Enhanced gene delivery into skeletal muscles with ultrasound and microbubble techniques. Zhang, Q., Wang, Z., Ran, H., Fu, X., Li, X., Zheng, Y., Peng, M., Chen, M., Schutt, C.E. Academic radiology. (2006) [Pubmed]
  20. The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography. Keller, M.W., Segal, S.S., Kaul, S., Duling, B. Circ. Res. (1989) [Pubmed]
  21. Myocardial contrast echocardiography in humans. II. Assessment of coronary blood flow reserve. Keller, M.W., Glasheen, W., Smucker, M.L., Burwell, L.R., Watson, D.D., Kaul, S. J. Am. Coll. Cardiol. (1988) [Pubmed]
  22. Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles. Korpanty, G., Chen, S., Shohet, R.V., Ding, J., Yang, B., Frenkel, P.A., Grayburn, P.A. Gene Ther. (2005) [Pubmed]
  23. The value of contrast cross-sectional echocardiography in the diagnosis of tricuspid regurgitation. Brown, A.K., Anderson, V. Eur. Heart J. (1984) [Pubmed]
  24. In vivo study of microbubbles as an MR susceptibility contrast agent. Wong, K.K., Huang, I., Kim, Y.R., Tang, H., Yang, E.S., Kwong, K.K., Wu, E.X. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2004) [Pubmed]
  25. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Weller, G.E., Wong, M.K., Modzelewski, R.A., Lu, E., Klibanov, A.L., Wagner, W.R., Villanueva, F.S. Cancer Res. (2005) [Pubmed]
  26. Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Coggins, M., Lindner, J., Rattigan, S., Jahn, L., Fasy, E., Kaul, S., Barrett, E. Diabetes (2001) [Pubmed]
  27. Real-time perfusion imaging with low mechanical index pulse inversion Doppler imaging. Porter, T.R., Xie, F., Silver, M., Kricsfeld, D., Oleary, E. J. Am. Coll. Cardiol. (2001) [Pubmed]
  28. Myocardial contrast two-dimensional echocardiography: dose-myocardial effect relations of intracoronary microbubbles. Shapiro, J.R., Xie, F., Meltzer, R.S. J. Am. Coll. Cardiol. (1988) [Pubmed]
  29. Two-dimensional contrast echocardiography. I. In vitro development and quantitative analysis of echo contrast agents. Feinstein, S.B., Ten Cate, F.J., Zwehl, W., Ong, K., Maurer, G., Tei, C., Shah, P.M., Meerbaum, S., Corday, E. J. Am. Coll. Cardiol. (1984) [Pubmed]
  30. Hepatocyte growth factor delivered by ultrasound-mediated destruction of microbubbles induces proliferation of cardiomyocytes and amelioration of left ventricular contractile function in Doxorubicin-induced cardiomyopathy. Iwasaki, M., Adachi, Y., Nishiue, T., Minamino, K., Suzuki, Y., Zhang, Y., Nakano, K., Koike, Y., Wang, J., Mukaide, H., Taketani, S., Yuasa, F., Tsubouchi, H., Gohda, E., Iwasaka, T., Ikehara, S. Stem Cells (2005) [Pubmed]
  31. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Lindner, J.R., Song, J., Christiansen, J., Klibanov, A.L., Xu, F., Ley, K. Circulation (2001) [Pubmed]
  32. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Molina, C.A., Ribo, M., Rubiera, M., Montaner, J., Santamarina, E., Delgado-Mederos, R., Arenillas, J.F., Huertas, R., Purroy, F., Delgado, P., Alvarez-Sabín, J. Stroke (2006) [Pubmed]
  33. Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Lindner, J.R., Coggins, M.P., Kaul, S., Klibanov, A.L., Brandenburger, G.H., Ley, K. Circulation (2000) [Pubmed]
  34. Improved myocardial contrast with second harmonic transient ultrasound response imaging in humans using intravenous perfluorocarbon-exposed sonicated dextrose albumin. Porter, T.R., Xie, F., Kricsfeld, D., Armbruster, R.W. J. Am. Coll. Cardiol. (1996) [Pubmed]
  35. A comparison of transesophageal echocardiography and transcranial Doppler sonography with contrast medium for detection of patent foramen ovale. Jauss, M., Kaps, M., Keberle, M., Haberbosch, W., Dorndorf, W. Stroke (1994) [Pubmed]
  36. Microbubbles in replicating nuclear deoxyribonucleic acid from Physarum polycephalum. Gillespie, D.A., Hardman, N. Biochem. J. (1979) [Pubmed]
  37. Myocardial contrast echocardiography: reliable, safe, and efficacious myocardial perfusion assessment after intravenous injections of a new echocardiographic contrast agent. Meza, M., Greener, Y., Hunt, R., Perry, B., Revall, S., Barbee, W., Murgo, J.P., Cheirif, J. Am. Heart J. (1996) [Pubmed]
 
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