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Chemical Compound Review

Valerolactone     5-methyloxolan-2-one

Synonyms: V403_ALDRICH, SureCN37255, AGN-PC-00GT15, CHEMBL195593, CCRIS 3597, ...
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Disease relevance of gamma-Methyl-gamma-butyrolactone


Psychiatry related information on gamma-Methyl-gamma-butyrolactone

  • The effects of an atypical barbiturate, 2-allophanyl-2-allyl-4-valerolactone (valofan), have been studied on spontaneous locomotor activity and amphetamine-induced hypermotility in mice [3].

High impact information on gamma-Methyl-gamma-butyrolactone


Chemical compound and disease context of gamma-Methyl-gamma-butyrolactone

  • No correlation seems to exist between the effects of valofan, on its own or combined with serotonergic agents, on motor activity and its effects on the accumulation of 5-HT and 5-HIAA [3].


  1. Effects of 2-allophanyl-2-allyl-4-valerolactone (valofan) on cerebral energy metabolism of rat in normoxia and hypobaric hypoxia. Traversa, U., Florio, C., Vertua, R. In Vivo (1987) [Pubmed]
  2. Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies workers exposed to hexane. Governa, M., Calisti, R., Coppa, G., Tagliavento, G., Colombi, A., Troni, W. Journal of toxicology and environmental health. (1987) [Pubmed]
  3. Effects of an atypical barbiturate (valofan) on spontaneous and stimulated locomotor activity and on brain serotonin metabolism in mice. Traversa, U., Puppini, P., Florio, C., Vertua, R. Il Farmaco; edizione scientifica. (1987) [Pubmed]
  4. Induction of chromosome loss by mixtures of organic solvents including neurotoxins. Zimmermann, F.K., Scheel, I., Resnick, M.A. Mutat. Res. (1989) [Pubmed]
  5. Analysis of n-hexane, 2-hexanone, 2,5-hexanedione, and related chemicals by capillary gas chromatography and high-performance liquid chromatography. Nomeir, A.A., Abou-Donia, M.B. Anal. Biochem. (1985) [Pubmed]
  6. Genetic change may be caused by interference with protein-protein interactions. Zimmermann, F.K., Gröschel-Stewart, U., Scheel, I., Resnick, M.A. Mutat. Res. (1985) [Pubmed]
  7. Determination of free and glucuronated hexane metabolites without prior hydrolysis by liquid- and gas-chromatography coupled with mass spectrometry. Manini, P., Andreoli, R., Mutti, A., Bergamaschi, E., Franchini, I. Toxicol. Lett. (1999) [Pubmed]
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