Disease relevance of gamma-Methyl-gamma-butyrolactone

• Effects of 2-allophanyl-2-allyl-4-valerolactone (valofan) on cerebral energy metabolism of rat in normoxia and hypobaric hypoxia [1].
• Since gamma-valerolactone is probably not a true metabolite of n-hexane, our results support the hypothesis that polyneuropathies in shoemakers are due to 2,5-hexanedione [2].

Psychiatry related information on gamma-Methyl-gamma-butyrolactone

• The effects of an atypical barbiturate, 2-allophanyl-2-allyl-4-valerolactone (valofan), have been studied on spontaneous locomotor activity and amphetamine-induced hypermotility in mice [3].

High impact information on gamma-Methyl-gamma-butyrolactone

• 1-Methyl-2-pyrrolidinone and gamma-valerolactone had previously been shown to induce chromosome loss only when the treatment at a growth-supporting temperature was interrupted by a cold shock within a narrow range of low temperatures which prevented growth [4].
• Normal-phase HPLC, using a 5-micron silica cartridge fitted into an RCM-100 radial-compression separation system, was utilized to analyze 2-hexanone and its metabolites 2,5-dimethylfuran, gamma-valerolactone, 5-hydroxy-2-hexanone, and 2,5-hexanedione.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
• Several aprotic polar solvents were shown to induce mitotic aneuploidy in yeast: diethyl ketone, gamma-valerolactone, pyridine, pivalinic acid nitrile, phenylacetonitrile and fumaric acid dinitrile [6].
• Whereas enzymatic hydrolysis did not increase the amount of 2,5-HD, acid hydrolysis led to increase 2,5-HD in variable amount and produced gamma-valerolactone as a result of a complete transformation of 4,5-dihydroxy-2-hexanone-G and the partial conversion from 5-hydroxy-2-hexanone-G [7].
• We can therefore suggest that valofan manifests its central effects by an unclear mechanism which cannot completely be accounted for its metabolic effects on cerebral serotonin and dopamine [3].

Chemical compound and disease context of gamma-Methyl-gamma-butyrolactone

• No correlation seems to exist between the effects of valofan, on its own or combined with serotonergic agents, on motor activity and its effects on the accumulation of 5-HT and 5-HIAA [3].

References