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Chemical Compound Review

Hexan-2-one     hexan-2-one

Synonyms: Hexanone, MNBK, Propylacetone, Hexanone-2, AGN-PC-0CR26N, ...
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Disease relevance of hexan-2-one


High impact information on hexan-2-one


Biological context of hexan-2-one


Anatomical context of hexan-2-one

  • Morphological evaluation suggested mitochondria respond differently to CHCl3 in ketone-pretreated (chlordecone or 2-hexanone) animals compared to corn oil-pretreated controls [9].
  • In a final experiment, ketone-pretreated (chlordecone or 2-hexanone) animals were killed 6 h after CHCl3 administration and evaluated morphologically for evidence of modified organelle response [9].
  • Like the immunoblot analysis, anti-P450IIE1(91) inhibited toluene side-chain hydroxylase activity in all microsomes, except in preparations from phenobarbital-treated rats and anti-P450IIB1 in microsomes from phenobarbital-, 2-hexanone- and acetonyl acetone-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)[10]

Associations of hexan-2-one with other chemical compounds


  1. Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione. Couri, D., Milks, M. Annu. Rev. Pharmacol. Toxicol. (1982) [Pubmed]
  2. MBK neuropathy among spray painters. Mallov, J.S. JAMA (1976) [Pubmed]
  3. Cross-linking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5-hexanedione. Lapadula, D.M., Irwin, R.D., Suwita, E., Abou-Donia, M.B. J. Neurochem. (1986) [Pubmed]
  4. A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats. Lubet, R.A., Nims, R.W., Dragnev, K.H., Jones, C.R., Diwan, B.A., Devor, D.E., Ward, J.M., Miller, M.S., Rice, J.M. Biochem. Pharmacol. (1992) [Pubmed]
  5. Induction of chromosome loss by mixtures of organic solvents including neurotoxins. Zimmermann, F.K., Scheel, I., Resnick, M.A. Mutat. Res. (1989) [Pubmed]
  6. Modifications in rat hepatobiliary function following treatment with acetone, 2-butanone, 2-hexanone, mirex, or chlordecone and subsequently exposed to chloroform. Hewitt, L.A., Ayotte, P., Plaa, G.L. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  7. Evaluation of individual components of plum odor as potential attractants for adult plum curculios. Leskey, T.C., Prokopy, R.J., Wright, S.E., Phelan, P.L., Haynes, L.W. J. Chem. Ecol. (2001) [Pubmed]
  8. Effect of aeration during cell growth on ketone reactions by immobilized yeast. Gervais, T.R., Carta, G., Gainer, J.L. Biotechnol. Prog. (2000) [Pubmed]
  9. Evidence for the involvement of organelles in the mechanism of ketone-potentiated chloroform-induced hepatotoxicity. Hewitt, L.A., Palmason, C., Masson, S., Plaa, G.L. Liver (1990) [Pubmed]
  10. Immunochemical detection of cytochrome P450 isozymes induced in rat liver by n-hexane, 2-hexanone and acetonyl acetone. Nakajima, T., Elovaara, E., Park, S.S., Gelboin, H.V., Vainio, H. Arch. Toxicol. (1991) [Pubmed]
  11. The effect of 2-hexanone and 2-hexanone metabolites on pupillomotor activity and growth. Abdel-Rahman, M.S., Saladin, J.J., Bohman, C.E., Couri, D. American Industrial Hygiene Association journal. (1978) [Pubmed]
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