Disease relevance of L-alpha-Aminobutyrate

• The structure of a complex between a hexapeptide-based inhibitor, MVT-101, and the chemically synthesized (Aba 67,95,167,195; Aba: L-alpha-amino-n-butyric acid) protease from the human immunodeficiency virus (HIV-1), reported previously at 2.3 A has now been refined to a crystallographic R factor of 15.4% at 2.0 A resolution [1].
• Engineering of a novel biochemical pathway for the biosynthesis of L-2-aminobutyric acid in Escherichia coli K12 [2].

High impact information on L-alpha-Aminobutyrate

• The kinetics are best described by a rapid equilibrium random ter-reactant mechanism, in which the model derived Kd values for the binding of L-Glu, L-alpha-aminobutyrate, and ATP to free enzyme are 2.6, 5.1, and 1.4 mM, respectively [3].
• A single peptide that was purified following alkaline borohydride treatment of the vitelline envelope had the structure: Abu-Pro-Abu-(Abu6, Pro1, Thr1), where Abu is 2-aminobutyric acid [4].
• The expression of yeaS (renamed leuE for "leucine export") was induced by leucine, l-alpha-amino-n-butyric acid and, to a lesser extent, by several other amino acids [5].
• In addition, p-HBA and vanillin in a dose-dependent fashion inhibit Fe(II)-H2O2-induced damage to benzoate, deoxyribose, glutamic acid, 2-aminobutyric acid and methionine, as well as benzoate hydroxylation [6].
• Amino acid limitation causes repression by promoting the accumulation of L-alanine or L-leucine or both. avtA is also repressed by L-alpha-aminobutyric acid and other nonprotein amino acids which are structurally similar to L-alanine [7].

Associations of L-alpha-Aminobutyrate with other chemical compounds

• We hypothesize that L-alanine and L-alpha-aminobutyric acid, whose syntheses are catalyzed by transaminase C, are the true corepressors of avtA . Repression by structural analogs of the true corepressors is termed gratuitous repression [7].
• An ESR study of the radicals in X-irradiated L-alpha-amino-n-butyric acid HCl containing 1.5% L-cysteine HCl [8].
• The selectivity of purified hGLCL holoenzyme for L-glutamate, L-alpha-aminobutyrate, or L-cysteine was significantly higher than for hGLCLC [9].
• Therefore, 2 novel N-terminal Ala(2)-substituted analogs of GIP, with Ala substituted by 2-aminobutyric acid (Abu) or sarcosine (Sar), were synthesized and tested for metabolic stability and biological activity both in vitro and in vivo [10].

Gene context of L-alpha-Aminobutyrate

• Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid [11].
• Erythroid progenitors from 2 patients with SCA, 1 patient with sickle/beta 0-thalassemia, and 1 patient with HbE/beta 0-thalassemia were co-cultured with IFN-gamma, L-alpha-amino-n-butyric acid, or both [12].
• HbF content (expressed as picograms HbF/cell) was decreased in samples co-cultured with IFN, increased in cultures with L-alpha-amino-n-butyric acid, but remained at control values in cultures treated with IFN plus L-alpha-amino-n-butyric acid [12].
• Chemical marker for ALS-inhibitor herbicides: 2-aminobutyric acid proportional in sub-lethal applications [13].

References