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Chemical Compound Review

AC1LGZT1     (1R,5R)-5-(2-hydroxypropan-2- yl)-2-methyl...

Synonyms: AKOS015913700, I14-45529, p-Menth-6-en-2,8-diol, cis
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Disease relevance of Sobrerol


High impact information on Sobrerol


Chemical compound and disease context of Sobrerol


Biological context of Sobrerol


Anatomical context of Sobrerol


Analytical, diagnostic and therapeutic context of Sobrerol

  • Side effects, which were minor and no different from those claimed by the patients treated with placebo, and the hematological and hematochemical assessments, carried out before and after treatment, support the good tolerance of sobrerol [12].
  • 706 chronic bronchitic patients were admitted to a double-blind controlled multicenter study to evaluate the effect of the prolonged administration of sobrerol on exacerbations, clinical signs and respiratory function indexes [12].
  • Treatment with sobrerol significantly (P less than 0.01) reduced frontal headache and rhinorrhoea, efficacy being confirmed by rhinomanometry [13].
  • A randomized double-blind study comparing the effect of 7 days treatment with 800 mg daily oral sobrerol versus placebo in two groups of 10 patients each, affected by chronic bronchitis, was performed [14].
  • A randomized double-blind cross-over study compared the clinical effectiveness of a 14-day treatment with 400 mg X day-1 of sobrerol and placebo in 23 patients with stable chronic bronchial disease [5].


  1. Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene. Crowell, P.L., Kennan, W.S., Haag, J.D., Ahmad, S., Vedejs, E., Gould, M.N. Carcinogenesis (1992) [Pubmed]
  2. Effect of limonene and sobrerol on monocrotaline-induced lung alterations and pulmonary hypertension. Touvay, C., Vilain, B., Carré, C., Mencia-Huerta, J.M., Braquet, P. Int. Arch. Allergy Immunol. (1995) [Pubmed]
  3. Pharmacokinetics of Sobrerol in chronic bronchitis. Comparison of serum and bronchial mucus levels. Braga, P.C., De Angelis, L., Bossi, R., Scaglione, F., Scarpazza, G., Allegra, L., Fraschini, F. Eur. J. Clin. Pharmacol. (1983) [Pubmed]
  4. Sobrerol in the treatment of secretory otitis media in childhood. Bellussi, L., Bernocchi, D., Ciferri, G., Manini, G., Passali, D. J. Int. Med. Res. (1989) [Pubmed]
  5. No demonstrable effect of sobrerol as an expectorant in patients with stable chronic bronchial diseases. Medici, T.C., Shang, H., Grosgurin, P., Berg, P., Achermann, R., Wehrli, R. Bulletin européen de physiopathologie respiratoire. (1985) [Pubmed]
  6. Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. Maltzman, T.H., Christou, M., Gould, M.N., Jefcoate, C.R. Carcinogenesis (1991) [Pubmed]
  7. Quantification of carvone, cineole, perillaldehyde, perillyl alcohol and sobrerol by isocratic high-performance liquid chromatography. Tao, L., Pereira, M.A. Journal of chromatography. A. (1998) [Pubmed]
  8. Sobrerol enantiomers and racemates: solid-state spectroscopy, thermal behavior, and phase diagrams. Bettinetti, G., Giordano, F., Fronza, G., Italia, A., Pellegata, R., Villa, M., Ventura, P. Journal of pharmaceutical sciences. (1990) [Pubmed]
  9. The metabolism of trans-sobrerol in the rat. Ventura, P., Schiavi, M., Serafini, S. Xenobiotica (1983) [Pubmed]
  10. Action of sobrerol on mucociliary transport. Allegra, L., Bossi, R., Braga, P.C. Respiration; international review of thoracic diseases. (1981) [Pubmed]
  11. Effects of sobrerol treatment on macromolecule secretion, ion and water fluxes in sheep trachea. Phipps, R.J., Denas, S.M., Torrealba, P.J., Peretz, A., Allegra, L. Bulletin européen de physiopathologie respiratoire. (1987) [Pubmed]
  12. Effect of long-term treatment with sobrerol on the exacerbations of chronic bronchitis. Castiglioni, C.L., Gramolini, C. Respiration; international review of thoracic diseases. (1986) [Pubmed]
  13. Evaluation of the efficacy and safety of sobrerol granules in patients suffering from chronic rhinosinusitis. Bellussi, L., Manini, G., Buccella, M.G., Cacchi, R. J. Int. Med. Res. (1990) [Pubmed]
  14. Monodisperse labeled aerosol to visualize airflow redistribution in the lung after a mucokinetic drug. Pulerà, N., Santolicandro, A., Bernard, P., Solfanelli, S., Giuntini, C. J. Nucl. Med. Allied Sci. (1989) [Pubmed]
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