Disease relevance of CARVONE

• A monoterpene epsilon-lactone hydrolase (MLH) from Rhodococcus erythropolis DCL14, catalyzing the ring opening of lactones which are formed during degradation of several monocyclic monoterpenes, including carvone and menthol, was purified to apparent homogeneity [1].
• The effects of two chemicals, L-2-oxothiazolidine-4-carboxylic acid (OTC) and (S)-carvone, were investigated on the development of necrotic symptoms and on the virus concentration in tobacco mosaic virus (TMV)-infected tobacco plants [2].
• Synthesis of ionones and carvone analogues: olfactory properties and preliminary toxicity assays [3].
• Allergic contact cheilitis due to carvone in toothpastes [4].
• Carvone, the principal component of spearmint oil, induces biodegradation of polychlorinated biphenyls (PCB) by Arthrobacter sp. strain B1B [5].

High impact information on CARVONE

• Detection and discrimination of carvone enantiomers in rats with olfactory bulb lesions [6].
• The effects of chiral fragrances (enantiomers of limonene and carvone) on the human autonomic nervous system (ANS) and on self-evaluation were studied in 20 healthy volunteers [7].
• FNC-B4 cells secreted activin A, and the highest accumulation in conditioned medium was achieved after 3h culture: the addition of forskolin, but not of carvone, was able to stimulate the release of activin A from cultured neuronal cells (P<0.01) [8].
• The monoterpene (S)-carvone increased only slightly the GSH content of leaf tissues and caused lipid peroxidation [2].
• Anethofuran, carvone, and limonene: potential cancer chemopreventive agents from dill weed oil and caraway oil [9].

Chemical compound and disease context of CARVONE

• The antiproliferative effect was evaluated in human prostate cancer LNCaP cells. l-Carvone, l-carveol, and l-limonene were weak cell growth inhibitors and introduction of 4-(2-methoxyphenyl)piperazine to carvone, carveol or limonene significantly increased their antiproliferative effect [10].
• Comparison of contact and fumigant toxicity of the test compounds indicates that l-carvone and d-carvone possess 24 times more fumigant toxicity toward adults of R. dominica than its contact toxicity [11].

Biological context of CARVONE

• The large amounts of carvone enantiomers consumed as food additives and in dental formulations justifies the evaluation of their biotransformation pathway [12].
• Percutaneous absorption of the montoterperne carvone: implication of stereoselective metabolism on blood levels [13].
• The results suggest that bioaugmentation with surfactant-grown, carvone-induced, PCB-degrading bacteria may provide an effective treatment for partial decontamination of PCB-contaminated soils [14].
• The influence of autoclaved fungal materials such as culture filtrate, freeze-dried mycelium (FDM), mycelium suspension, and spore suspension (SS) on the growth, morphogenesis, and carvone production of spearmint (Mentha spicata L.) plants was studied [15].
• Formulation and in vivo evaluation of membrane-moderated transdermal therapeutic systems of nicardipine hydrochloride using carvone as a penetration enhancer [16].

Anatomical context of CARVONE

• Stereoselective metabolism of the monoterpene carvone by rat and human liver microsomes [12].
• Discrimination between the enantiomers of carvone and of terpinen-4-ol odorants in normal rats and those with lesions of the olfactory bulbs [17].

Associations of CARVONE with other chemical compounds

• By using a specific ELISA, dimeric activin A concentrations were measured in culture media, in the absence or presence of carvone or forskolin and with different doses of progesterone, GnRH, and estradiol [8].
• The compounds that were most active against both processes belonged to the groups of ketones and alcohols; they were terpinen-4-ol, dihydrocarvone, and two carvone stereoisomers [18].
• Linalool, a non-sensitizer structurally unrelated to carvone, significantly reduced the sensitizing capacity of carvone in guinea pigs [19].
• Addition of cell-free, carvone/fructose medium resulted in 10% degradation of PCB, which suggests that this treatment stimulated biodegradation of PCB by the indigenous microflora [5].
• This study investigated the effectiveness of the repeated application of carvone-induced bacteria for bioremediation of Aroclor-1242-contaminated soil [5].

Gene context of CARVONE

• The carvone-based drug reservoir system was sandwiched between adhesive-coated EVA 2825-release liner composite and a backing membrane [20].
• Thus a new transdermal therapeutic system for nimodipine was formulated using EVA 2825 membrane, coated with a pressure-sensitive adhesive TACKWHITE 4A MED, and 2% w/w HPMC gel as reservoir containing 10% w/w of carvone as a penetration enhancer [21].
• Pretreatment with terpenes (e.g. 5% w/v, carvone, pulegone, cineole and menthol in EtOH:W (2:1) system) increased (P < 0.05) the flux of AVP in comparison to control (not pretreated with enhancer) but was not significantly different (P > 0.05) in comparison to iontophoresis [22].

Analytical, diagnostic and therapeutic context of CARVONE

• The angle-resolved photoemission from the carbonyl carbon C=O core orbital in pure carvone enantiomers shows a pronounced circular dichroism of approximately 6% at the magic angle of 54.7 degrees to the light beam propagation direction [23].
• Estimation of the main dill seeds odorant carvone by solid-phase microextraction and gas chromatography [24].
• The carvone-based TTS provided a steady-state plasma concentration of 20.5 ng/ml for approximately 24 hr in human volunteers [20].
• The selected essential oil components (menthol, (+)bomeol, geraniol, linalool, carvone, camphor, (IR)-(-)fenchone) were separated by adsorption thin-layer chromatography using benzene as mobile phase [25].

References