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Disease relevance of Rhinomanometry


High impact information on Rhinomanometry

  • Five and 30 minutes after each allergen provocation, rhinal airflow was measured by means of anterior rhinomanometry and the subjective symptoms obstruction, itching, and rhinorrhea were assessed by means of a standardized visual analog scale [5].
  • Total nasal airflow, measured by rhinomanometry, significantly (p <0.05) improved in the fluticasone propionate group compared with the terfenadine group or the placebo group [6].
  • Capsaicin induced a dose-dependent decrease in nasal airflow conductance (active posterior rhinomanometry) (p < 0.002) that was greater in patients with allergic rhinitis (0.40 +/- 0.02 to 0.20 +/- 0.03) than in healthy subjects (0.44 +/- 0.01 to 0.35 +/- 0.02) (p = 0.0001) [7].
  • 4. Subjective NAR, nasal secretions and rhinomanometry recordings were not modified by intranasal application of saline, NPY or oxymetazoline [8].
  • Nasal resistance was measured by passive anterior rhinomanometry (PAR), and changes in histamine threshold were calculated together with the absolute number of sneezes after each challenge [9].

Biological context of Rhinomanometry


Anatomical context of Rhinomanometry

  • The test uses active anterior rhinomanometry and a histamine titration method, challenging both nasal cavities with a metered dose pump [12].
  • NAR was measured by posterior rhinomanometry, and expressed as the inspiratory resistance at a flow of 0.5 L/s. Dental impressions were taken to evaluate maxillary arch morphology, allowing measurement of the following distances: intercuspid (ICD), interpremolar (IPD), intermolar (IMD), and maximum hard palate height (MPH) [13].
  • Before challenge and on each of 5 treatment days, all volunteers were asked to rate symptom severity and were evaluated for secretion production (weighted tissues), nasal patency (active posterior rhinomanometry), nasal clearance (dyed saccharin technique), eustachian tube function (9-step test), and middle ear status (tympanometry) [14].

Associations of Rhinomanometry with chemical compounds

  • A dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology [15].
  • The objective of the present study was to investigate nasal function by active anterior rhinomanometry with respect to spirometric data and bronchial hyperresponsiveness to methacholine in 9-year-old children [16].
  • A preliminary evaluation of the effect of N-acetyl-aspartyl-glutamate on pollen nasal challenge as measured by rhinomanometry and symptomatology [17].
  • One week of treatment with the active steroid significantly reduced the nasal secretion compared to placebo as measured with the aid of a symptom score, and significantly reduced the induced nasal blockage measured objectively by means of rhinomanometry [18].
  • An established method of nasal provocation was used to determine the effects of topically applied NPY on nasal resistance to airflow measured by anterior rhinomanometry, the protein content of nasal secretions, and the protein content of bradykinin-induced secretions [19].

Gene context of Rhinomanometry


Analytical, diagnostic and therapeutic context of Rhinomanometry


  1. Cytologic changes in the nasal secretions during the immediate nasal response. Pelikan, Z., Pelikan-Filipek, M. J. Allergy Clin. Immunol. (1988) [Pubmed]
  2. The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. Eccles, R., Jawad, M.S., Morris, S. J. Pharm. Pharmacol. (1990) [Pubmed]
  3. Nasal physiological changes during pregnancy. Philpott, C.M., Conboy, P., Al-Azzawi, F., Murty, G. Clinical otolaryngology and allied sciences. (2004) [Pubmed]
  4. Dose-response relationship of a topical nasal decongestant: phenylpropanolamine. Bende, M., Andersson, K.E., Johansson, C.J., Sjögren, C., Svensson, G. Acta Otolaryngol. (1984) [Pubmed]
  5. The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis. Schmidt, B.M., Kusma, M., Feuring, M., Timmer, W.E., Neuhäuser, M., Bethke, T., Stuck, B.A., Hörmann, K., Wehling, M. J. Allergy Clin. Immunol. (2001) [Pubmed]
  6. Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis. Bronsky, E.A., Dockhorn, R.J., Meltzer, E.O., Shapiro, G., Boltansky, H., LaForce, C., Ransom, J., Weiler, J.M., Blumenthal, M., Weakley, S., Wisniewski, M., Field, E., Rogenes, P. J. Allergy Clin. Immunol. (1996) [Pubmed]
  7. Nasal response to capsaicin in patients with allergic rhinitis and in healthy volunteers: effect of colchicine. Roche, N., Lurie, A., Authier, S., Dusser, D.J. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  8. Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects. Lacroix, J.S., Ricchetti, A.P., Morel, D., Mossimann, B., Waeber, B., Grouzmann, E. Br. J. Pharmacol. (1996) [Pubmed]
  9. Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers. Wang, D.Y., Hanotte, F., De Vos, C., Clement, P. Allergy (2001) [Pubmed]
  10. Effects of topical treatment with H1 and H2 antagonists on clinical symptoms and nasal vascular reactions in patients with allergic rhinitis. Holmberg, K., Pipkorn, U., Bake, B., Blychert, L.O. Allergy (1989) [Pubmed]
  11. The effect of nasal mucosal vasoconstriction on nasal airflow sensation. Clarke, R.W., Cook, J.A., Jones, A.S. Clinical otolaryngology and allied sciences. (1995) [Pubmed]
  12. Histamine nasal provocation test. An evaluation of active anterior rhinomanometry and of threshold criteria of provocative dose. Van de Heyning, P.H., Van Haesendonck, J., Creten, W., de Saegher, D., Claes, J. Allergy (1989) [Pubmed]
  13. Influence of maxillary constriction on nasal resistance and sleep apnea severity in patients with Marfan's syndrome. Cistulli, P.A., Richards, G.N., Palmisano, R.G., Unger, G., Berthon-Jones, M., Sullivan, C.E. Chest (1996) [Pubmed]
  14. Therapeutic effects of an anticholinergic-sympathomimetic combination in induced rhinovirus colds. Doyle, W.J., Riker, D.K., McBride, T.P., Hayden, F.G., Hendley, J.O., Swarts, J.D., Gwaltney, J.M. The Annals of otology, rhinology, and laryngology. (1993) [Pubmed]
  15. A dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology. Meltzer, E.O., Orgel, H.A., Bronsky, E.A., Furukawa, C.T., Grossman, J., LaForce, C.F., Lemanske, R.F., Paull, B.D., Pearlman, D.S., Ratner, P.H. J. Allergy Clin. Immunol. (1990) [Pubmed]
  16. Nasal function and bronchial hyperresponsiveness to methacholine in children. Kiss, D., Popp, W., Horak, F., Wagner, C., Zwick, H. Chest (1995) [Pubmed]
  17. A preliminary evaluation of the effect of N-acetyl-aspartyl-glutamate on pollen nasal challenge as measured by rhinomanometry and symptomatology. Ghaem, A. Allergy (1987) [Pubmed]
  18. Budesonide and nasal allergen challenge testing in man. Pipkorn, U. Allergy (1982) [Pubmed]
  19. Neuropeptide Y is a vasoconstrictor in human nasal mucosa. Baraniuk, J.N., Silver, P.B., Kaliner, M.A., Barnes, P.J. J. Appl. Physiol. (1992) [Pubmed]
  20. Nasal response to substance P and methacholine in subjects with and without allergic rhinitis. Devillier, P., Dessanges, J.F., Rakotosihanaka, F., Ghaem, A., Boushey, H.A., Lockhart, A., Marsac, J. Eur. Respir. J. (1988) [Pubmed]
  21. Rhinomanometry. I. Simple equipment. Broms, P., Ivarsson, A., Jonson, B. Acta Otolaryngol. (1982) [Pubmed]
  22. Pulmonary function parameters in patients with allergic rhinitis. Bavbek, S., Saryal, S., Karabiyikoglu, G., Misirligil, Z. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. (2003) [Pubmed]
  23. Non-specific nasal provocation test with histamine. Analysis of the dose-response curve. Zambetti, G., Moresi, M., Romeo, R., Luce, M., Filiaci, F. Rhinology. (1999) [Pubmed]
  24. Efficacy of topical tuaminoheptane combined with N-acetyl-cysteine in reducing nasal resistance. A double-blind rhinomanometric study versus xylometazoline and placebo. Cogo, A., Chieffo, A., Farinatti, M., Ciaccia, A. Arzneimittel-Forschung. (1996) [Pubmed]
  25. Acoustic rhinometry compared with anterior rhinomanometry in the assessment of the response to nasal allergen challenge. Scadding, G.K., Darby, Y.C., Austin, C.E. Clinical otolaryngology and allied sciences. (1994) [Pubmed]
  26. Parietaria judaica and dermo-respiratory allergy in Barcelona: a study of 250 cases. Valero Santiago, A., Malet i Casajuana, A., García Calderón, P.A. Allergologia et immunopathologia. (1988) [Pubmed]
  27. A comparison of the effects of xylometazoline on nasal airflow, and on blood flux as measured by laser Doppler flowmetry. Wight, R.G., Cochrane, T. Acta Otolaryngol. (1989) [Pubmed]
  28. Research of non-specific hyperreactivity of upper airways in subjects with gastro-esophageal reflux (G.E.R.): preliminary reports. Filiaci, F., Zambetti, G., Luce, M., Lo Vecchio, A., Docimo, M., Romeo, R. Allergologia et immunopathologia. (1997) [Pubmed]
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