Disease relevance of Otitis Media with Effusion

• In a randomized, double-blind, placebo-controlled trial involving 518 infants and children who had otitis media with effusion ("secretory" otitis media), we evaluated the efficacy of a two-week course of amoxicillin (40 mg per kilogram of body weight per day) with and without a four-week course of an oral decongestant-antihistamine combination [1].
• Consequently, allergic rhinitis is linked to comorbid conditions: asthma, chronic hyperplastic eosinophilic sinusitis, nasal polyposis, and serous otitis media [2].
• Nimesulide treatment for 7 to 10 days is shown to be effective in controlling the inflammatory process in upper airways disorders such as rhinitis, rhinosinusitis, rhinopharyngitis and tubaritis, and in middle ear disorder (secretory otitis media) [3].
• Azithromycin (10 mg/kg) was administered as a single dose 12, 24 or 48 h before the insertion of tympanostomy tubes to 17 children with secretory otitis media and once daily for 5 days (10 mg/kg on day 1, 5 mg/kg on days 2-5) to 12 children with acute otitis media [4].
• In 76% of the patients diagnosed as recurrent exudative tonsillitis, and in 33% diagnosed as recurrent tonsillitis and/or serous otitis media, EBNA was demonstrated in the purified TDLs [5].

Psychiatry related information on Otitis Media with Effusion

• The effect of a conductive hearing loss secondary to serous otitis media in children with sensorineural hearing loss was seen to be an increase in threshold and in one case a decrease in speech discrimination [6].

High impact information on Otitis Media with Effusion

• Penetration of erythromycin to middle ear fluid of patients with chronic serous otitis media [7].
• In the 16 evaluable patients with secretory otitis media, azithromycin penetrated middle ear effusions, with group mean concentrations approximately two orders of magnitude greater than the concurrent plasma concentrations 12, 24 and 48 h after administration [4].
• Clarithromycin suspension was given at a dosage of 7.5 mg/kg bd for 7 days to 31 children with secretory otitis media, scheduled for insertion of grommets [8].
• Many of the children with recurrent serous otitis media required repeated myringotomies with placement of ventilation tubes, and those with sensorineural hearing losses required sound amplification during childhood [9].
• Treatment of secretory otitis media with local instillation of hydroxyzine [10].

Chemical compound and disease context of Otitis Media with Effusion

• Histamine and secretory otitis media [11].
• The study is a preliminary single-blind, placebo- and prednisolone-controlled investigation of the treatment of 156 children with otitis media with effusion (secretory otitis media, SOM), ranging from 2 to 12 years [10].
• Antibiotic treatment of children with secretory otitis media. Amoxicillin-clavulanate is superior to penicillin V in a double-blind randomized study [12].
• SMX/TMP was also administered to children with serous otitis media [13].
• The possible use of spiramycin for prevention of relapses in acute otitis media and in treatment of serous otitis media is discussed, as well as the possible use of the drug in gonococcal and meningococcal nasopharyngeal carriage [14].

Biological context of Otitis Media with Effusion

• The use of 0.5% chlorhexidine in 70% alcohol for disinfection of the ear-canal in children with serous otitis media [15].
• The babies who failed the screening tests included 9 with sensorineural hearing loss, three with secretory otitis media, and three with abnormal auditory brain stem response tests [16].
• (1975) model to high impedance pathologies and to identify tympanometric parameters associated with otosclerosis, secretory otitis media, and lateral ossicular fixation [17].

Anatomical context of Otitis Media with Effusion

• Five animals were also subjected to blocking of the Eustachian tube, 3 to 8 months earlier, resulting in serous otitis media and exotoxin A (1 mg/ml) was applied into the round window niche of these animals [18].
• Adenoid histamine and its possible relationship to secretory otitis media [19].
• T cells as marked with acid alpha-naphthyl acetate esterase staining in secretory otitis media [20].
• In order to study the penetration of doxycycline (Idocyklin) in respiratory mucosa 100 mg tablets were given in standard dosage to 58 patients with longstanding secretory otitis media, the "secretion-in-cavity" model, and to 37 patients with nasal polyposis, the tissue model [21].
• In subacute and acute pathological actions, especially tubal occlusion, and chronic diseases, such as active chronic otitis and in secretory otitis media, the goblet-cell density is appreciably increased [22].

Gene context of Otitis Media with Effusion

• Presence of dipeptidyl peptidase II, dipeptidyl peptidase IV, and prolyl endopeptidase in effusion from patients with serous otitis media [23].
• By means of ELISA with phenylated C-Ps, anti-C-Ps IgG was measured in samples of plasma and upper airway secretions from otitis-prone children (OP), children with fewer episodes of recurrent acute otitis media (rAOM), and children with no previous history of AOM, but suffering from secretory otitis media (SOM) [24].
• 4. A review of patients treated for serous otitis media with myringotomy and tubal insertion in 1968 [25].
• Two hundred thirty-two patients with nasopharyngeal carcinoma were evaluated for serous otitis media (SOM) at diagnosis [26].
• Plasmin and fibronectin degradation in chronic secretory otitis media [27].

Analytical, diagnostic and therapeutic context of Otitis Media with Effusion

• Seventy-nine patients that had persistent or recurrent secretory otitis media for over 3 months and were scheduled for myringotomy and/or adenoidectomy received a single dose of cefaclor (20 or 40 mg/kg) orally 0.5-4 hours before surgery [28].
• Tympanometry in 3-year-old children. Type of care as an epidemiological factor in secretory otitis media and tubal dysfunction in unselected populations of 3-year-old children [29].
• Multicenter study on the treatment of secretory otitis media with ambroxol. Importance of a surface-tension-lowering substance [30].
• In an attempt to elucidate if N-acetylcysteine is capable of preventing the changes caused by secretory otitis media and ventilation tubes we administered different doses of the substance locally to the middle ear of an animal model [31].
• The postural effect on the tubal function is slight and the advice to place the patient's head during bed rest in a position of at least 20 degrees above the horizontal level has hardly any significance in the prevention or treatment of acute or secretory otitis media [32].

References