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Chemical Compound Review

AG-E-80479     trimethylselanium

Synonyms: CTK4F6773, AR-1L7489, LS-144827, BRN 1731764, AC1L3MD1, ...
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Disease relevance of trimethylselenonium


High impact information on trimethylselenonium

  • We also undertook a separate bioavailability study using Se-methylselenocysteine, dimethyl selenoxide, and trimethylselenonium as the starting compounds for delivering selenium with one, two, or three methyl groups, and measured the ability of these compounds to restore glutathione peroxidase activity in selenium-depleted animals [2].
  • In order to clarify the species composition of selenium in environmental water samples, analytical methods have been developed for the selective determination of different chemical forms of this element (selenite, selenate, and organic species including trimethylselenonium) using isotope dilution mass spectrometry (IDMS) [3].
  • The organ- and selenium source-specific production of TMSe was discussed as to the differences in selenium sources, and demethylation and methylation activity [4].
  • Effect of moisture and casein on demethylation of trimethylselenonium in soil [5].

Analytical, diagnostic and therapeutic context of trimethylselenonium


  1. Biological activities of trimethylselenonium as influenced by arsenite. Ip, C., Ganther, H. J. Inorg. Biochem. (1992) [Pubmed]
  2. Chemical form of selenium, critical metabolites, and cancer prevention. Ip, C., Hayes, C., Budnick, R.M., Ganther, H.E. Cancer Res. (1991) [Pubmed]
  3. Determination of dissolved selenium species in environmental water samples using isotope dilution mass spectrometry. Tanzer, D., Heumann, K.G. Anal. Chem. (1991) [Pubmed]
  4. Availability and metabolism of (77)Se-methylseleninic acid compared simultaneously with those of three related selenocompounds. Suzuki, K.T., Ohta, Y., Suzuki, N. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  5. Effect of moisture and casein on demethylation of trimethylselenonium in soil. Zhang, Y., Frankenberger, W.T. Sci. Total Environ. (2000) [Pubmed]
  6. Determination of trimethylselenonium ion in urine by ion-exchange chromatography and molecular neutron activation analysis. Blotcky, A.J., Hansen, G.T., Opelanio-Buencamino, L.R., Rack, E.P. Anal. Chem. (1985) [Pubmed]
  7. Effect of chronic selenite supplementation on selenium excretion and organ accumulation in rats. Janghorbani, M., Rockway, S., Mooers, C.S., Roberts, E.M., Ting, B.T., Sitrin, M.D. J. Nutr. (1990) [Pubmed]
  8. Analysis of trimethylselenonium ion in urine by high-performance liquid chromatography. Kraus, R.J., Foster, S.J., Ganther, H.E. Anal. Biochem. (1985) [Pubmed]
  9. Analysis of selenium metabolites in urine samples of minke whale (Balaenoptera Acutorostrata) using ion exchange chromatography. Hasunuma, R., Ogawa, T., Fujise, Y., Kawanishi, Y. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1993) [Pubmed]
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