Disease relevance of trimethylselenonium

• The present study was designed to evaluate three biological activities of trimethylselenonium (TMSe+): anticarcinogenicity, toxicity, and nutritional availability [1].

High impact information on trimethylselenonium

• We also undertook a separate bioavailability study using Se-methylselenocysteine, dimethyl selenoxide, and trimethylselenonium as the starting compounds for delivering selenium with one, two, or three methyl groups, and measured the ability of these compounds to restore glutathione peroxidase activity in selenium-depleted animals [2].
• In order to clarify the species composition of selenium in environmental water samples, analytical methods have been developed for the selective determination of different chemical forms of this element (selenite, selenate, and organic species including trimethylselenonium) using isotope dilution mass spectrometry (IDMS) [3].
• The organ- and selenium source-specific production of TMSe was discussed as to the differences in selenium sources, and demethylation and methylation activity [4].
• Effect of moisture and casein on demethylation of trimethylselenonium in soil [5].

Analytical, diagnostic and therapeutic context of trimethylselenonium

• Determination of trimethylselenonium ion in urine by ion-exchange chromatography and molecular neutron activation analysis [6].
• Excretion of trimethylselenonium ion (TMSe) in urine increased rapidly, representing 35-40% of urinary Se in the supplemented animals compared with only 2% for the control group [7].
• A rapid and simple method for the separation of trimethylselenonium ion and other cationic forms of selenium in urine by HPLC on a strong cation exchanger is described [8].
• Analysis of trimethylselenonium ion in urine by high-performance liquid chromatography [8].
• 2. From whale urine, five selenium components, including trimethylselenonium ion were separated and determined by a combination of ion exchange chromatography and fluorometry [9].

References