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Chemical Compound Review

CHEBI:9068     2-amino-3-methylselanyl- propanoic acid

Synonyms: NSC-319053, CTK8H8640, NSC319053, AR-1E7797, LS-174110, ...
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Disease relevance of C05689


High impact information on C05689


Anatomical context of C05689


Associations of C05689 with other chemical compounds

  • Based on the above in vitro and in vivo findings, it is hypothesized that the Se-garlic extract, in part via the action of Se-methylselenocysteine, is able to inhibit tumorigenesis by suppressing the proliferation and reducing the survival of the early transformed cells [10].
  • The present work determines both previously observed organoselenium species such as selenomethionine and Se-methylselenocysteine and for the first time detects the newly characterized S-(methylseleno)cysteine in plant shoots and roots when grown in the presence of selenate or selenite as the only selenium source [11].

Gene context of C05689


Analytical, diagnostic and therapeutic context of C05689


  1. Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy. Peariso, K., Zhou, Z.S., Smith, A.E., Matthews, R.G., Penner-Hahn, J.E. Biochemistry (2001) [Pubmed]
  2. Se-methylselenocysteine: a new compound for chemoprevention of breast cancer. Medina, D., Thompson, H., Ganther, H., Ip, C. Nutrition and cancer. (2001) [Pubmed]
  3. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Yeo, J.K., Cha, S.D., Cho, C.H., Kim, S.P., Cho, J.W., Baek, W.K., Suh, M.H., Kwon, T.K., Park, J.W., Suh, S.I. Cancer Lett. (2002) [Pubmed]
  4. In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Ip, C., Thompson, H.J., Zhu, Z., Ganther, H.E. Cancer Res. (2000) [Pubmed]
  5. A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation. Neuhierl, B., Thanbichler, M., Lottspeich, F., Böck, A. J. Biol. Chem. (1999) [Pubmed]
  6. Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1alpha expression, resulting in reduced angiogenesis. Yin, M.B., Li, Z.R., Tóth, K., Cao, S., Durrani, F.A., Hapke, G., Bhattacharya, A., Azrak, R.G., Frank, C., Rustum, Y.M. Oncogene (2006) [Pubmed]
  7. Se-methylselenocysteine induces apoptosis mediated by reactive oxygen species in HL-60 cells. Jung, U., Zheng, X., Yoon, S.O., Chung, A.S. Free Radic. Biol. Med. (2001) [Pubmed]
  8. On the mechanism of selenium tolerance in selenium-accumulating plants. Purification and characterization of a specific selenocysteine methyltransferase from cultured cells of Astragalus bisculatus. Neuhierl, B., Böck, A. Eur. J. Biochem. (1996) [Pubmed]
  9. Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase D1 activation in U937 cells. Lee, T.J., Kim, Y.H., Min, d.o. .S., Park, J.W., Kwon, T.K. Immunobiology (2006) [Pubmed]
  10. Effect on an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention. Lu, J., Pei, H., Ip, C., Lisk, D.J., Ganther, H., Thompson, H.J. Carcinogenesis (1996) [Pubmed]
  11. Chromatographic speciation of anionic and neutral selenium compounds in Se-accumulating Brassica juncea (Indian mustard) and in selenized yeast. Kahakachchi, C., Boakye, H.T., Uden, P.C., Tyson, J.F. Journal of chromatography. A. (2004) [Pubmed]
  12. Enzymatic synthesis of selenocysteine in rat liver. Esaki, N., Nakamura, T., Tanaka, H., Suzuki, T., Morino, Y., Soda, K. Biochemistry (1981) [Pubmed]
  13. Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland. Ip, C., Thompson, H.J., Ganther, H.E. Cancer Epidemiol. Biomarkers Prev. (2000) [Pubmed]
  14. Se-methylselenocysteine activates caspase-3 in mouse mammary epithelial tumor cells in vitro. Unni, E., Singh, U., Ganther, H.E., Sinha, R. Biofactors (2001) [Pubmed]
  15. Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. Jang, B.C., Choi, E.S., Im, K.J., Baek, W.K., Kwon, T.K., Suh, M.H., Kim, S.P., Park, J.W., Suh, S.I. Int. J. Mol. Med. (2003) [Pubmed]
  16. Osteopontin is a potential target gene in mouse mammary cancer chemoprevention by Se-methylselenocysteine. Unni, E., Kittrell, F.S., Singh, U., Sinha, R. Breast Cancer Res. (2004) [Pubmed]
  17. Characterization of the biological activity of gamma-glutamyl-Se-methylselenocysteine: a novel, naturally occurring anticancer agent from garlic. Dong, Y., Lisk, D., Block, E., Ip, C. Cancer Res. (2001) [Pubmed]
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