Disease relevance of Ostertagia

• Cellular and chemical mediators of type 1 hypersensitivity in calves infected with Ostertagia ostertagi: histamine, prostaglandin D2, prostaglandin E2 and leukotriene C4 [1].
• Under experimental conditions, fenbendazole given at doses of 0.4 and 1.0 mg/kg body weight suppressed calves' faecal output of Ostertagia and Cooperia species eggs and Dictyocaulus viviparus larvae [2].
• The oxfendazole pulse release bolus provided good control of parasitic gastroenteritis dominated by ostertagia [3].
• On administration of Ostertagia ostertagi larvae, Co-depleted cattle showed a greater weight loss than Co-supplemented cattle but showed no difference in the length of the prepatent period, worm egg production or serum gastrin and pepsinogen concentrations [4].

High impact information on Ostertagia

• Vaccination with an Ostertagia ostertagi polyprotein allergen protects calves against homologous challenge infection [5].
• Effects of Ostertagia ostertagi on gastrin gene expression and gastrin-related responses in the calf [6].
• Full-length or partial coding sequences of 4 different zinc-metalloprotease cDNAs of Ostertagia (met-1, -2, -3 and -4) were amplified using gene-specific primers using the 3'- and 5'-Rapid Amplification of cDNA Ends (RACE) technique [7].
• An aspartyl protease inhibitor of Ostertagia ostertagi: molecular cloning, analysis of stage and tissue specific expression and vaccine trial [8].
• Intramuscular immunization of calves with an excretory-secretory antigen fraction enriched for cysteine proteinase activity (ES-thiol) and QuilA as adjuvant induces a protective immune response against the abomasal nematode Ostertagia ostertagi [9].

Chemical compound and disease context of Ostertagia

• In calves given doses of 8 mg of levamisole/kg of body weight and 5 and 7.5 mg of fenbendazole/kg, reductions of adult Ostertagia were 95%, 99%, and 99% respectively [10].

Biological context of Ostertagia

• Isolation and characterization of surface marker phenotypes of abomasal intraepithelial (IEL), lamina propria (LPL) and abomasal lymph node lymphocytes (ABLN) from uninfected calves were conducted, and the dynamics of change in these populations during the course of a primary Ostertagia ostertagi infection were defined [11].
• The effects of modifying drug administration and food intake upon the efficacy of fenbendazole against resistant isolates of Teladorsagia (Ostertagia) circumcincta were investigated using naturally infected sheep and goats [12].
• The primers were biased toward the nucleotide and codon usages of cysteine proteinase genes of nematodes and were based on the consensus nucleotide sequences flanking the active site residues of genes from Haemonchus contortus, Caenorhabditis elegans, and Ostertagia ostertagi [13].

Anatomical context of Ostertagia

• The nematode species Spiculopteragia spiculoptera, Spiculopteragia asymmetrica and Ostertagia leptospicularis were recovered from the abomasum of wild red deer, Cervus elaphus, in the forest area of the semi-arid Pampeana Region of La Pampa (Argentina) for the first time [14].
• Carbachol and secretions from Ostertagia species parasites significantly (P less than 0.001) stimulated isolated preparations of dispersed gastric glands from bovine and ovine abomasal mucosa to secrete pepsinogen [15].
• Serum pepsinogen concentrations rose more rapidly and to higher levels in adult sheep infected with Ostertagia circumcincta and treated orally with the mast cell stabilising agent sodium cromoglycate than they did in adult sheep infected with the parasite which remained untreated [16].
• The circulating fructosamine level was investigated in the lamb as an indicator of protein-losing gastroenteropathy associated with two parasites at different sites, Ostertagia circumcincta (abomasum) and Nematodirus spathiger (small intestine) [17].

Associations of Ostertagia with chemical compounds

• The effect of selection with levamisole on benzimidazole resistance in Ostertagia spp. of sheep [18].
• Selection for thiabendazole resistance in Ostertagia spp. by low efficiency anthelmintic treatment [19].
• Further studies with a strain of Ostertagia ostertagi resistant to morantel tartrate [20].
• Two experiments with a morantel resistant strain of Ostertagia ostertagi were carried out [20].
• Isolation of putative cysteine protease genes of Ostertagia ostertagi [21].

Gene context of Ostertagia

• The 31,000 mol. wt glycoprotein (GP31) antigen of infective third-stage (L3) Ostertagia circumcincta larvae was shown, by surface labelling experiments and immunofluorescent antibody staining of whole larvae and larval sections, to be distributed internally [22].
• A pepstatin A-agarose column was used in an attempt to purify a previously described antibody-degrading aspartyl proteinase from excretory-secretory material from the L4 and the adult stages of the bovine abomasal nematode Ostertagia ostertagi [23].
• Protein disulphide isomerase of Ostertagia ostertagi: an excretory-secretory product of L4 and adult worms [23]?
• Ostertagia circumcincta: isolation of a partial cDNA encoding an unusual member of the mitochondrial processing peptidase subfamily of M16 metallopeptidases [24].
• Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults [25].

Analytical, diagnostic and therapeutic context of Ostertagia

• PROCEDURE: 2 dose titration studies-0, 125, 250, and 500 micrograms of eprinomectin/kg of body weight-Louisiana and Georgia- and 2 dose confirmation studies of selected therapeutic dosage (500 micrograms/kg) in Scotland and France. Monitor calves were used to determine inhibition percentage of Ostertagia IL4 [26].
• Plasma concentrations of febantel and its major metabolites fenbendazole, oxfendazole and oxfendazole sulphone were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection with 50,000 L3 larvae of Ostertagia circumcincta or Trichostrongylus colubriformis [27].
• Calves infected by surgical transplantation of adult Ostertagia ostertagi had raised levels of plasma pepsinogen and those in which the largest number of worms established also had elevated plasma gastrin concentrations [28].

References