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Chemical Compound Review

Repidose     methyl N-[6-(phenylsulfinyl)-1H...

Synonyms: Systamex, Systemax, Synanthic, Oxfendazol, Oxfendazole, ...
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Disease relevance of Fenbendazole sulfoxide

  • Cyst fertility and parasite viability were measured following daily, weekly, and monthly treatment schedules with 30 mg of oxfendazole per kg of body weight [1].
  • If found safe in humans, oxfendazole may prove to be a useful and inexpensive treatment for cestode infections in humans [1].
  • This study suggests that a staggered dosing regimen of oxfendazole, and possibly other benzimidazoles, may be as efficacious as daily treatment regimens for hydatidosis while decreasing both the cost and adverse effects associated with daily dosing [1].
  • Effective, single-dose treatment or porcine cysticercosis with oxfendazole [2].
  • A single dose of 5 mg of praziquantel was given to eliminate intestinal taeniasis in humans, and two rounds of oxfendazole (30 mg/kg) were administered to all pigs [3].

Psychiatry related information on Fenbendazole sulfoxide


High impact information on Fenbendazole sulfoxide


Chemical compound and disease context of Fenbendazole sulfoxide


Biological context of Fenbendazole sulfoxide


Anatomical context of Fenbendazole sulfoxide


Associations of Fenbendazole sulfoxide with other chemical compounds


Analytical, diagnostic and therapeutic context of Fenbendazole sulfoxide


  1. Oxfendazole treatment of sheep with naturally acquired hydatid disease. Dueger, E.L., Moro, P.L., Gilman, R.H. Antimicrob. Agents Chemother. (1999) [Pubmed]
  2. Effective, single-dose treatment or porcine cysticercosis with oxfendazole. Gonzales, A.E., Garcia, H.H., Gilman, R.H., Gavidia, C.M., Tsang, V.C., Bernal, T., Falcon, N., Romero, M., Lopez-Urbina, M.T. Am. J. Trop. Med. Hyg. (1996) [Pubmed]
  3. Combined human and porcine mass chemotherapy for the control of T. solium. Garcia, H.H., Gonzalez, A.E., Gilman, R.H., Moulton, L.H., Verastegui, M., Rodriguez, S., Gavidia, C., Tsang, V.C. Am. J. Trop. Med. Hyg. (2006) [Pubmed]
  4. Time-response curve of oxfendazole in the treatment of swine cysticercosis. Gonzalez, A.E., Falcon, N., Gavidia, C., Garcia, H.H., Tsang, V.C., Bernal, T., Romero, M., Gilman, R.H. Am. J. Trop. Med. Hyg. (1998) [Pubmed]
  5. In vitro febantel transformation by sheep and cattle ruminal fluids and metabolism by hepatic subcellular fractions from different animal species. Beretta, C., Fadini, L., Stracciari, J.M., Montesissa, C. Biochem. Pharmacol. (1987) [Pubmed]
  6. A comparison of the interaction of anthelmintic benzimidazoles with tubulin isolated from mammalian tissue and the parasitic nematode Ascaridia galli. Dawson, P.J., Gutteridge, W.E., Gull, K. Biochem. Pharmacol. (1984) [Pubmed]
  7. Immunomodulatory effect of various anti-parasitics: a review. Sajid, M.S., Iqbal, Z., Muhammad, G., Iqbal, M.U. Parasitology (2006) [Pubmed]
  8. Porcine antibody responses to taenia solium antigens rGp50 and sTs18var1. Handali, S., Gonzalez, A.E., Hancock, K., Garcia, H.H., Roberts, J.M., Gilman, R.H., Tsang, V.C. Am. J. Trop. Med. Hyg. (2004) [Pubmed]
  9. The establishment rate of Ostertagia circumcincta and Trichostrongylus colubriformis in lactating Romney ewes. Leathwick, D.M., Miller, C.M., Brown, A.E., Sutherland, I.A. Int. J. Parasitol. (1999) [Pubmed]
  10. Ecological hazard assessment of major veterinary benzimidazoles: acute and chronic toxicities to aquatic microbes and invertebrates. Oh, S.J., Park, J., Lee, M.J., Park, S.Y., Lee, J.H., Choi, K. Environ. Toxicol. Chem. (2006) [Pubmed]
  11. Critical test evaluations of oxfendazole and trichlorfon: effectiveness of a paste formulation in the horse. Presson, B.L., Hamm, D., Yazwinski, T.A., Pote, L.M. Am. J. Vet. Res. (1984) [Pubmed]
  12. The pharmacokinetics of fenbendazole and oxfendazole in cattle. Ngomuo, A.J., Marriner, S.E., Bogan, J.A. Vet. Res. Commun. (1984) [Pubmed]
  13. Gastric Ollulanus tricuspis infection identified in captive cheetahs (Acinonyx jubatus) with chronic vomiting. Collett, M.G., Pomroy, W.E., Guilford, W.G., Johnstone, A.C., Blanchard, B.J., Mirams, S.G. Journal of the South African Veterinary Association. (2000) [Pubmed]
  14. Pharmacokinetics of oxfendazole in sheep. Marriner, S.E., Bogan, J.A. Am. J. Vet. Res. (1981) [Pubmed]
  15. Relationship among particle size distribution, dissolution profile, plasma values, and anthelmintic efficacy of oxfendazole. Shastri, S., Mroszczak, E., Prichard, R.K., Parekh, P., Nguyen, T.H., Hennessey, D.R., Schiltz, R. Am. J. Vet. Res. (1980) [Pubmed]
  16. The effect of cooking on veterinary drug residues in food; 5. Oxfendazole. Rose, M.D., Shearer, G., Farrington, W.H. Food additives and contaminants. (1997) [Pubmed]
  17. Dexamethasone decreases plasma levels of the prochiral fenbendazole and its chiral and achiral metabolites in sheep. Sánchez, S., Small, J., Jones, D.G., McKellar, Q.A. Xenobiotica (2003) [Pubmed]
  18. Therapeutic and protective efficacy of doramectin injectable against gastrointestinal nematodes in cattle in New Zealand: a comparison with moxidectin and ivermectin pour-on formulations. Hooke, F.G., Clement, P., Dell'Osa, D., Porter, R.M., MacColl, D., Rew, R.S. Vet. Parasitol. (1997) [Pubmed]
  19. The partition and fate of soluble and digesta particulate associated oxfendazole and its metabolites in the gastrointestinal tract of sheep. Hennessy, D.R., Ali, D.N., Tremain, S.A. Int. J. Parasitol. (1994) [Pubmed]
  20. Evaluation of the effect of oxfendazole on sperm production and semen quality in boars. Larsson, B., Jernström, M. Int. J. Androl. (1983) [Pubmed]
  21. Disposition of fenbendazole in the goat. Short, C.R., Barker, S.A., Hsieh, L.C., Ou, S.P., Davis, L.E., Koritz, G., Neff-Davis, C.A., Bevill, R.F., Munsiff, I.J., Sharma, G.C. Am. J. Vet. Res. (1987) [Pubmed]
  22. Genotoxical, teratological and biochemical effects of anthelmintic drug oxfendazole Maximum Residue Limit (MRL) in male and female mice. El-Makawy, A., Radwan, H.A., Ghaly, I.S., El-Raouf, A.A. Reprod. Nutr. Dev. (2006) [Pubmed]
  23. The efficacy of levamisole, and a mixture of oxfendazole and levamisole, against the arrested stages of benzimidazole-resistant Haemonchus contortus and Ostertagia circumcincta in sheep. Andrews, S.J. Vet. Parasitol. (2000) [Pubmed]
  24. Interactions of benzimidazoles (BZ) with tubulin from BZ-sensitive and BZ-resistant isolates of Haemonchus contortus. Lacey, E., Prichard, R.K. Mol. Biochem. Parasitol. (1986) [Pubmed]
  25. Changes in the acetylcholinesterase activity of the nematode Nippostrongylus brasiliensis following treatment with benzimidazoles in vivo. Rapson, E.B., Lee, D.L., Watts, S.D. Mol. Biochem. Parasitol. (1981) [Pubmed]
  26. Anthelmintic resistant nematodes in goats in The Netherlands. Borgsteede, F.H., Pekelder, J.J., Dercksen, D.P. Vet. Parasitol. (1996) [Pubmed]
  27. Effects of three benzimidazole anthelmintics on the ruminal fermentation ability of sheep. Jara, W., Sumano, H., Ocampo, L. Vet. Rec. (1984) [Pubmed]
  28. Glucose uptake in Oesophagostomum dentatum and the effect of oxfendazole. Petersen, M.B., Friis, C. Vet. Parasitol. (1998) [Pubmed]
  29. Inducing effect of oxfendazole on cytochrome P450IA2 in rabbit liver. Consequences on cytochrome P450 dependent monooxygenases. Gleizes, C., Eeckhoutte, C., Pineau, T., Alvinerie, M., Galtier, P. Biochem. Pharmacol. (1991) [Pubmed]
  30. Protection of pigs with cysticercosis from further infections after treatment with oxfendazole. Gonzalez, A.E., Gavidia, C., Falcon, N., Bernal, T., Verastegui, M., Garcia, H.H., Gilman, R.H., Tsang, V.C. Am. J. Trop. Med. Hyg. (2001) [Pubmed]
  31. Radioimmunoassay of oxfendazole in bovine, equine, or canine plasma or serum. Nerenberg, C., Runkel, R.A., Matin, S.B. Journal of pharmaceutical sciences. (1978) [Pubmed]
  32. Determination of oxfendazole in cow milk by reversed-phase high-performance liquid chromatography. Tsina, I.W., Matin, S.B. Journal of pharmaceutical sciences. (1981) [Pubmed]
  33. Pharmacokinetics of fenbendazole following intravenous and oral administration to pigs. Petersen, M.B., Friis, C. Am. J. Vet. Res. (2000) [Pubmed]
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