Disease relevance of Fenbendazole sulfoxide

• Cyst fertility and parasite viability were measured following daily, weekly, and monthly treatment schedules with 30 mg of oxfendazole per kg of body weight [1].
• If found safe in humans, oxfendazole may prove to be a useful and inexpensive treatment for cestode infections in humans [1].
• This study suggests that a staggered dosing regimen of oxfendazole, and possibly other benzimidazoles, may be as efficacious as daily treatment regimens for hydatidosis while decreasing both the cost and adverse effects associated with daily dosing [1].
• Effective, single-dose treatment or porcine cysticercosis with oxfendazole [2].
• A single dose of 5 mg of praziquantel was given to eliminate intestinal taeniasis in humans, and two rounds of oxfendazole (30 mg/kg) were administered to all pigs [3].

Psychiatry related information on Fenbendazole sulfoxide

• Time-response curve of oxfendazole in the treatment of swine cysticercosis [4].

High impact information on Fenbendazole sulfoxide

• Febantel and one of its main metabolites, febantel sulphoxide, are chemically modified to only a slight extent when incubated in vitro with sheep and cattle ruminal fluids; other major metabolites, fenbendazole and oxfendazole, are respectively, oxidized to oxfendazole and reduced to fenbendazole [5].
• In particular, oxfendazole and thiabendazole had virtually no effect on mammalian tubulin assembly whereas they were both good inhibitors of nematode tubulin polymerization [6].
• This paper reviews the immunomodulatory effects (immunosuppression or immunoactivation) of various anthelmintics including levamisole, fenvalerate, dieldrin, carbofuran, aminocarb, thiabendazole, fenbendazole, oxfendazole and ivermectin [7].
• First, we followed the kinetics of antibody responses against these two diagnostic proteins in pigs with cysticercosis that were treated with oxfendazole [8].
• Either 2, 4 or 6 weeks after parturition, groups of ewes were dosed with 24000 L3 of known oxfendazole-resistant parasite strains; 12000 of each species [9].

Chemical compound and disease context of Fenbendazole sulfoxide

• Aquatic toxicities of six benzimidazole-based anthelmintics-namely, albendazole, thiabendazole, flubendazole, febantel, fenbendazole, and oxfendazole-were evaluated with a marine bacterium, Vibrio fischeri, and a freshwater invertebrate, Daphnia magna [10].
• The rates of active ingredient administration were 2.5 and 40 mg/kg of body weight for oxfendazole and trichlorfon, respectively [11].
• Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 microgram/ml respectively [12].
• Treatment with oxfendazole and pyrantel embonate resulted in clinical improvement; however, 1 cheetah, which died 7 months later as a result of a ruptured liver due to hepatic amyloidosis, still had Ollulanus worms present in her stomach [13].

Biological context of Fenbendazole sulfoxide

• Pharmacokinetics of oxfendazole in sheep [14].
• A comparative bioavailability study of these 3 suspensions was performed in 12 sheep with each sheep given each formulation in a Latin square crossover study design; oxfendazole was dosed at rate of 5 mg/kg of body weight [15].
• The effect of cooking on veterinary drug residues in food; 5. Oxfendazole [16].
• The shape of the plasma concentration-time curves for oxfendazole (OFZ) and fenbendazole sulphone (FBZSO(2)) were similar to FBZ, raising the possibility that DXM treatment may have altered the liver biotransformation of the parent drug [17].
• The better parasite control provided by doramectin resulted in greater weight gains for cattle over the 56-day period as compared to moxidectin pour-on, ivermectin pour-on and oxfendazole in both trials [18].

Anatomical context of Fenbendazole sulfoxide

• The partition and fate of soluble and digesta particulate associated oxfendazole and its metabolites in the gastrointestinal tract of sheep [19].
• Evaluation of the effect of oxfendazole on sperm production and semen quality in boars [20].
• The active metabolite, oxfendazole, appeared in plasma, but only trace amounts were found in feces or urine [21].
• The toxicity of oxfendazole (MRL) was tested in male and female mice and their fetuses [22].
• The efficacies of the treatments were assessed by estimation of the arrested larval burden in the abomasum of each sheep, either at 10 or 11 days (oxfendazole and oxfendazole/levamisole mixture), or 12 or 13 days (levamisole), after treatment [23].

Associations of Fenbendazole sulfoxide with other chemical compounds

• The binding of tritiated benzimidazoles (BZs)-albendazole, parbendazole, oxibendazole, mebendazole, oxfendazole and fenbendazole-to crude tubulin extracts from BZ-susceptible and -resistant Haemonchus contortus has been examined [24].
• Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) activities of Nippostrongylus brasiliensis were measured following treatment of the hosts with oxfendazole and mebendazole [25].
• Benzimidazole resistance was found in Haemonchus contortus, Teladorsagia circumcincta, Cooperia curticei and Trichostrongylus colubriformis with the efficacy of oxfendazole being 68%, 31%, 21% and 48% respectively [26].
• The effects of albendazole, fenbendazole and oxfendazole on the fermentation ability of the rumen were assessed in 12 Dorset sheep, using as parameters volatile fatty acid concentration, percentage digestibility of cellulose in vitro and pH [27].
• During a 7 h incubation period, the quantity of glucose remaining in the incubation medium of oxfendazole exposed worms was significantly greater than in the control group [28].

Analytical, diagnostic and therapeutic context of Fenbendazole sulfoxide

• Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increased 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95 and 184% increases) as demonstrated by western blotting [29].
• Protection of pigs with cysticercosis from further infections after treatment with oxfendazole [30].
• Radioimmunoassay of oxfendazole in bovine, equine, or canine plasma or serum [31].
• Determination of oxfendazole in cow milk by reversed-phase high-performance liquid chromatography [32].
• Oxfendazole was the major plasma metabolite, accounting for two-thirds of the total area under the plasma concentration versus time curve after IV and oral administration [33].

References