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MeSH Review

Peritoneal Cavity

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Disease relevance of Peritoneal Cavity


High impact information on Peritoneal Cavity

  • In vivo, antigen-induced T-cell recruitment into the peritoneal cavity was reversed by high but not low concentrations of SDF-1 [6].
  • Antibody to human PECAM-1, which cross-reacts with rat PECAM-1, was found to block not only in vivo accumulation of rat neutrophils into the peritoneal cavity and the alveolar compartment of the lung but also neutrophil accumulation in human skin grafts transplanted onto immunodeficient mice [7].
  • Overt bleeding events develop shortly after birth in approximately 30% of A alpha-/- mice, most frequently in the peritoneal cavity, skin, and soft tissues around joints [8].
  • However, CD5+ B cells (B-1 cells) in the peritoneal cavity were reduced by 50%-80% in 2-week-old IL-5-/- mice, returning to normal by 6-8 weeks of age [9].
  • In addition, macrophages resident in the peritoneal cavity do not express MHC class II molecules upon IFN gamma stimulation nor do somatic tissues of mice injected with IFN gamma, in contrast with wild-type mice [10].

Chemical compound and disease context of Peritoneal Cavity


Biological context of Peritoneal Cavity


Anatomical context of Peritoneal Cavity


Associations of Peritoneal Cavity with chemical compounds

  • Macrophages that have increased immunosuppressive activity and that produce increased amounts of PGE2 appear in the peritoneal cavity of tumor-dormant mice before the breakdown of the tumor-dormant state and formation of ascitic tumors [26].
  • Injection of the purified cysteine proteinase into the peritoneal cavity of mice resulted in a progressive cleavage of plasma kininogens and the concomitant release of kinins over a period of 5 h [27].
  • The purified toxin was enterotoxic in ligated rabbit ileal loops and neurotoxic when injected into the peritoneal cavity of mice [28].
  • We conducted a phase I trial to investigate the feasibility of using dipyridamole to selectively increase the sensitivity to etoposide of tumors confined to the peritoneal cavity [29].
  • Immunoglobulin, C4, and C3 content increased with length of time spent in the peritoneal cavity [30].

Gene context of Peritoneal Cavity

  • Constitutive macrophage trafficking into the peritoneal cavity was not significantly different between CCR2-deficient and wild-type mice [31].
  • Release of eosinophilic major basic protein (MBP), IL-4, and IL-5 to the peritoneal cavity of these mice was significantly increased when compared with the control FVB strain [32].
  • Leukocyte infiltration into the peritoneal cavity in response to MIP-2 was also inhibited by prior treatment of mice with GROalpha(8-73) or the analogue of platelet factor 4, PF4(9-70) [33].
  • The results of this study indicate 1) that the murine receptor for MIP-2 and KC, muCXCR2, plays a major role in neutrophil recruitment to s.c. tissue and the peritoneal cavity in response to proinflammatory agents and 2) that CXCR2 receptor antagonists prevent acute inflammation in vivo [33].
  • Additional macrophage populations proved to be very M-CSF dependent. op/op mice had few and sometimes no peritoneal cavity phagocytes, splenic marginal zone metallophils, and lymph node subcapsular sinus macrophages [34].

Analytical, diagnostic and therapeutic context of Peritoneal Cavity


  1. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. Murakami, M., Tsubata, T., Shinkura, R., Nisitani, S., Okamoto, M., Yoshioka, H., Usui, T., Miyawaki, S., Honjo, T. J. Exp. Med. (1994) [Pubmed]
  2. Surface properties of bacillus Calmette-Guérin-activated mouse macrophages. Reduced expression of mannose-specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia. Ezekowitz, R.A., Austyn, J., Stahl, P.D., Gordon, S. J. Exp. Med. (1981) [Pubmed]
  3. Detection of ovarian cancer cells: comparison of a telomerase assay and cytologic examination. Duggan, B.D., Wan, M., Yu, M.C., Roman, L.D., Muderspach, L.I., Delgadillo, E., Li, W.Z., Martin, S.E., Dubeau, L. J. Natl. Cancer Inst. (1998) [Pubmed]
  4. Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Buchmeier, N.A., Schreiber, R.D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Alimzhanov, M.B., Kuprash, D.V., Kosco-Vilbois, M.H., Luz, A., Turetskaya, R.L., Tarakhovsky, A., Rajewsky, K., Nedospasov, S.A., Pfeffer, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Active movement of T cells away from a chemokine. Poznansky, M.C., Olszak, I.T., Foxall, R., Evans, R.H., Luster, A.D., Scadden, D.T. Nat. Med. (2000) [Pubmed]
  7. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Vaporciyan, A.A., DeLisser, H.M., Yan, H.C., Mendiguren, I.I., Thom, S.R., Jones, M.L., Ward, P.A., Albelda, S.M. Science (1993) [Pubmed]
  8. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Suh, T.T., Holmbäck, K., Jensen, N.J., Daugherty, C.C., Small, K., Simon, D.I., Potter, S., Degen, J.L. Genes Dev. (1995) [Pubmed]
  9. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Kopf, M., Brombacher, F., Hodgkin, P.D., Ramsay, A.J., Milbourne, E.A., Dai, W.J., Ovington, K.S., Behm, C.A., Köhler, G., Young, I.G., Matthaei, K.I. Immunity (1996) [Pubmed]
  10. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Chang, C.H., Guerder, S., Hong, S.C., van Ewijk, W., Flavell, R.A. Immunity (1996) [Pubmed]
  11. Intraperitoneal chemotherapy with high-dose cisplatin and cytosine arabinoside for refractory ovarian carcinoma and other malignancies principally involving the peritoneal cavity. Markman, M., Cleary, S., Lucas, W.E., Howell, S.B. J. Clin. Oncol. (1985) [Pubmed]
  12. Doxorubicin encapsulated in sterically stabilized liposomes is superior to free drug or drug-containing conventional liposomes at suppressing growth and metastases of human lung tumor xenografts. Sakakibara, T., Chen, F.A., Kida, H., Kunieda, K., Cuenca, R.E., Martin, F.J., Bankert, R.B. Cancer Res. (1996) [Pubmed]
  13. A rationale for carboplatin treatment and abdominal hyperthermia in cancers restricted to the peritoneal cavity. Los, G., Smals, O.A., van Vugt, M.J., van der Vlist, M., den Engelse, L., McVie, J.G., Pinedo, H.M. Cancer Res. (1992) [Pubmed]
  14. Exchange of macromolecules between plasma and peritoneal cavity in ascites tumor-bearing, normal, and serotonin-injected mice. Nagy, J.A., Herzberg, K.T., Masse, E.M., Zientara, G.P., Dvorak, H.F. Cancer Res. (1989) [Pubmed]
  15. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. Takamura, M., Sakamoto, M., Genda, T., Ichida, T., Asakura, H., Hirohashi, S. Hepatology (2001) [Pubmed]
  16. Systemic induction of cells mediating antibody-dependent cellular cytotoxicity following administration of interleukin 2. Eisenthal, A., Rosenberg, S.A. Cancer Res. (1989) [Pubmed]
  17. Accelerated clearance of Escherichia coli in experimental peritonitis of histamine-deficient mice. Hori, Y., Nihei, Y., Kurokawa, Y., Kuramasu, A., Makabe-Kobayashi, Y., Terui, T., Doi, H., Satomi, S., Sakurai, E., Nagy, A., Watanabe, T., Ohtsu, H. J. Immunol. (2002) [Pubmed]
  18. Suppression of NK-mediated natural resistance by interferon treatment of murine lymphomas. Greenberg, A.H., Miller, V., Jablonski, T., Pohajdak, B. J. Immunol. (1984) [Pubmed]
  19. B1 cells contribute to serum IgM, but not to intestinal IgA, production in gnotobiotic Ig allotype chimeric mice. Thurnheer, M.C., Zuercher, A.W., Cebra, J.J., Bos, N.A. J. Immunol. (2003) [Pubmed]
  20. Generation, expansion, migration and activation of mouse B1 cells. Fagarasan, S., Watanabe, N., Honjo, T. Immunol. Rev. (2000) [Pubmed]
  21. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. Kunkel, E.J., Jung, U., Bullard, D.C., Norman, K.E., Wolitzky, B.A., Vestweber, D., Beaudet, A.L., Ley, K. J. Exp. Med. (1996) [Pubmed]
  22. Growth of B-lymphocyte colonies in vitro. Metcalf, D., Nossal, G.J., Warner, N.L., Miller, J.F., Mandel, T.E., Layton, J.E., Gutman, G.A. J. Exp. Med. (1975) [Pubmed]
  23. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. Nocka, K., Buck, J., Levi, E., Besmer, P. EMBO J. (1990) [Pubmed]
  24. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Bichi, R., Shinton, S.A., Martin, E.S., Koval, A., Calin, G.A., Cesari, R., Russo, G., Hardy, R.R., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo. Thompson, J.A., Haudenschild, C.C., Anderson, K.D., DiPietro, J.M., Anderson, W.F., Maciag, T. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  26. Immune regulation of the L5178Y murine tumor-dormant state. I. In vivo and in vitro effects of prostaglandin E2 and indomethacin on tumor cell growth. Liu, C.M., Okayasu, T., Goldman, P., Suzuki, Y., Suzuki, K., Wheelock, E.F. J. Exp. Med. (1986) [Pubmed]
  27. Streptococcal cysteine proteinase releases kinins: a virulence mechanism. Herwald, H., Collin, M., Müller-Esterl, W., Björck, L. J. Exp. Med. (1996) [Pubmed]
  28. Pathogenesis of Shigella diarrhea. IX. Simplified high yield purification of Shigella toxin and characterization of subunit composition and function by the use of subunit-specific monoclonal and polyclonal antibodies. Donohue-Rolfe, A., Keusch, G.T., Edson, C., Thorley-Lawson, D., Jacewicz, M. J. Exp. Med. (1984) [Pubmed]
  29. Phase I and pharmacokinetic trial of intraperitoneal etoposide in combination with the multidrug-resistance-modulating agent dipyridamole. Isonishi, S., Kirmani, S., Kim, S., Plaxe, S.C., Braly, P.S., McClay, E.F., Howell, S.B. J. Natl. Cancer Inst. (1991) [Pubmed]
  30. Persistence of immunoglobulin and complement components C4 and C3 bound to guinea pig tumor cells. Segerling, M., Ohanian, S.H., Borsos, T. J. Natl. Cancer Inst. (1976) [Pubmed]
  31. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Kuziel, W.A., Morgan, S.J., Dawson, T.C., Griffin, S., Smithies, O., Ley, K., Maeda, N. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  32. Interleukin 9 promotes influx and local maturation of eosinophils. Louahed, J., Zhou, Y., Maloy, W.L., Rani, P.U., Weiss, C., Tomer, Y., Vink, A., Renauld, J., Van Snick, J., Nicolaides, N.C., Levitt, R.C., Haczku, A. Blood (2001) [Pubmed]
  33. Inhibition of murine neutrophil recruitment in vivo by CXC chemokine receptor antagonists. McColl, S.R., Clark-Lewis, I. J. Immunol. (1999) [Pubmed]
  34. Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse. Witmer-Pack, M.D., Hughes, D.A., Schuler, G., Lawson, L., McWilliam, A., Inaba, K., Steinman, R.M., Gordon, S. J. Cell. Sci. (1993) [Pubmed]
  35. Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages. Werb, Z., Chin, J.R. J. Exp. Med. (1983) [Pubmed]
  36. CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Baumgarth, N., Jager, G.C., Herman, O.C., Herzenberg, L.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  37. Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Bozkurt, B., Kribbs, S.B., Clubb, F.J., Michael, L.H., Didenko, V.V., Hornsby, P.J., Seta, Y., Oral, H., Spinale, F.G., Mann, D.L. Circulation (1998) [Pubmed]
  38. The pharmacology of intraperitoneally administered bleomycin. Howell, S.B., Schiefer, M., Andrews, P.A., Markman, M., Abramson, I. J. Clin. Oncol. (1987) [Pubmed]
  39. Macrophage accumulation in murine ascites tumors. I. Cytoxan-induced dominance of macrophages over tumor cells and the anti-tumor effect of endotoxin. Dye, E.S., North, R.J. J. Immunol. (1980) [Pubmed]
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