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Gene Review

Pcsk9  -  proprotein convertase subtilisin/kexin type 9

Mus musculus

Synonyms: AI415265, AI747682, FH3, HCHOLA3, NARC-1, ...
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Disease relevance of Pcsk9


High impact information on Pcsk9


Biological context of Pcsk9

  • This phenotype closely resembles that reported previously in Pcsk9-deficient mice [4].
  • Overexpression in the P388D1 cells of full-length FRL or of the truncated protein containing the FH3 and FH1 domains, with simultaneous expression of the truncated FH3-FRL protein, blocked apoptotic cell death and inhibition of cell adhesion and migration [3].

Anatomical context of Pcsk9

  • Accordingly, transfection of NARC-1 in primary cultures of embryonic day 13.5 telencephalon cells led to enhanced recruitment of undifferentiated neural progenitor cells into the neuronal lineage, suggesting that NARC-1 is implicated in the differentiation of cortical neurons [5].
  • METHODS AND RESULTS: Using quantitative RT-PCR, we assessed NARC-1 regulation under conditions known to regulate genes involved in cholesterol metabolism in HepG2 cells and in human primary hepatocytes [6].

Other interactions of Pcsk9


  1. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Rashid, S., Curtis, D.E., Garuti, R., Anderson, N.N., Bashmakov, Y., Ho, Y.K., Hammer, R.E., Moon, Y.A., Horton, J.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Maxwell, K.N., Breslow, J.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Yayoshi-Yamamoto, S., Taniuchi, I., Watanabe, T. Mol. Cell. Biol. (2000) [Pubmed]
  4. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. Graham, M.J., Lemonidis, K.M., Whipple, C.P., Subramaniam, A., Monia, B.P., Crooke, S.T., Crooke, R.M. J. Lipid Res. (2007) [Pubmed]
  5. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Seidah, N.G., Benjannet, S., Wickham, L., Marcinkiewicz, J., Jasmin, S.B., Stifani, S., Basak, A., Prat, A., Chretien, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Dubuc, G., Chamberland, A., Wassef, H., Davignon, J., Seidah, N.G., Bernier, L., Prat, A. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  7. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Lambert, G., Jarnoux, A.L., Pineau, T., Pape, O., Chetiveaux, M., Laboisse, C., Krempf, M., Costet, P. Endocrinology (2006) [Pubmed]
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