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Gene Review

ARL4C  -  ADP-ribosylation factor-like 4C

Homo sapiens

Synonyms: ADP-ribosylation factor-like protein 4C, ADP-ribosylation factor-like protein 7, ADP-ribosylation factor-like protein LAK, ARL7, LAK
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Disease relevance of ARL4C

  • A total of 157 postmenopausal women aged over 60 years with osteoporosis were divided into five groups according to their postural deformities: round back (RB, n=41), hollow round back (HRB, n=33), whole kyphosis (WK, n=40), lower acute kyphosis (LAK, n=18), and normal posture (NP, n=25) [1].
  • Human LAK-sensitive K-562; and LAK-resistant myeloid leukemia cell lines (DAMI, HL-60 and Meg-01) as well as 6 LAK-resistant myeloid leukemia patient samples were utilized [2].
  • Summary: IL-2 plus autogeneic LAK cells can be safely administered intracavitary to treat high grade primary brain tumors with limited toxicity within the central nervous system [3].

High impact information on ARL4C

  • A role for natural killer (NK)- and LAK-cell-mediated killing is suggested because IL-2-primed peripheral blood mononuclear cells (PBMCs) treated with Thal/IMiDs demonstrated significantly increased lysis of MM cell lines [4].
  • However, 2 of the lymphoma-derived Ig's (ARL-7 and ARL-14) bound strongly to non-HIV-infected cells of various tissue origins [5].
  • Here we define the sequence and structural determinants that propagate information across the protein and identify them in all of the Arf family proteins other than Arl6 and Arl4/Arl7 [6].
  • This data is consistent with a model in which ARL7 is involved in transport between a perinuclear compartment and the plasma membrane apparently linked to the ABCA1-mediated cholesterol secretion pathway [7].
  • ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export [7].

Anatomical context of ARL4C

  • Moreover, subcellular distribution of mutant and wild type ARL7-enhanced green fluorescent protein (EGFP) supports that ARL7 may be involved in a vesicular transport step between a perinuclear compartment and the plasma membrane [7].
  • Here, we identify ADP-ribosylation factor (ARF)-like 7 (ARL7) as the only ARF- and ARL-family member whose mRNA-expression is induced by liver X-receptor/retinoid X-receptor agonists or cholesterol loading in human macrophages [7].
  • We have developed an aggressive treatment program that utilizes low doses of interleukin-2 (IL-2) combined with ex vivo activated killer cells (LAK) infused via an indwelling catheter placed into the surgical resection cavity [3].

Associations of ARL4C with chemical compounds

  • Therefore, we investigated the effect of ARL7 over-expression on the cholesterol secretory pathway [7].


  1. Impact of postural deformities and spinal mobility on quality of life in postmenopausal osteoporosis. Miyakoshi, N., Itoi, E., Kobayashi, M., Kodama, H. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2003) [Pubmed]
  2. Evaluation of human mast cell-mediated cytotoxicity by DIOC18 target cell labeling in flow cytometry. Ozdemir, O. J. Immunol. Methods (2007) [Pubmed]
  3. Adoptive cellular immunotherapy for the treatment of malignant gliomas. Hayes, R.L., Arbit, E., Odaimi, M., Pannullo, S., Scheff, R., Kravchinskiy, D., Zaroulis, C. Crit. Rev. Oncol. Hematol. (2001) [Pubmed]
  4. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Davies, F.E., Raje, N., Hideshima, T., Lentzsch, S., Young, G., Tai, Y.T., Lin, B., Podar, K., Gupta, D., Chauhan, D., Treon, S.P., Richardson, P.G., Schlossman, R.L., Morgan, G.J., Muller, G.W., Stirling, D.I., Anderson, K.C. Blood (2001) [Pubmed]
  5. Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens. Cunto-Amesty, G., Przybylski, G., Honczarenko, M., Monroe, J.G., Silberstein, L.E. Blood (2000) [Pubmed]
  6. Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication. Pasqualato, S., Renault, L., Cherfils, J. EMBO Rep. (2002) [Pubmed]
  7. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. Engel, T., Lueken, A., Bode, G., Hobohm, U., Lorkowski, S., Schlueter, B., Rust, S., Cullen, P., Pech, M., Assmann, G., Seedorf, U. FEBS Lett. (2004) [Pubmed]
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