Disease relevance of HRB

• The other three genes were annexin XI, human HIV Rev-interacting protein Rip-1, and the human homologue of the ATP-binding arsA component of the bacterial arsenite transporter, all of which are known to be widely expressed in human tissues [1].
• Thus, hRIP is an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export: movement of RNAs from the nuclear periphery to the cytoplasm [2].
• The Rating of Anorexia and Bulimia interview (RAB) is a Swedish semi-structured interview for clinical and research purposes for a wide range of eating disorder symptoms and related psychopathology [3].
• A total of 157 postmenopausal women aged over 60 years with osteoporosis were divided into five groups according to their postural deformities: round back (RB, n=41), hollow round back (HRB, n=33), whole kyphosis (WK, n=40), lower acute kyphosis (LAK, n=18), and normal posture (NP, n=25) [4].
• In the current study, which included a large sample (N = 369) of patients referred for neuropsychological (NP) evaluation after presumptive head injury, MMPI-2 measures of psychological disturbance accounted for as much as 25% of the variance in HRB test scores, resulting in a moderate overall effect size (median Adj. R(2) = .16; R = .40) [5].

Psychiatry related information on HRB

• The results indicated significant effects for age and education on many of the tests, with smaller but statistically significant relationships between the quality of HRB test performance and MMPI scores [6].
• Recently, Tremont, Hoffman, Scott, and Adams (1998) demonstrated an association between Halstead-Reitan (HRB) and Wechsler Memory Scale (WMS) performance and WAIS-R IQ scores, and recommended that premorbid intellectual estimates be utilized as general indicators of expected neuropsychological test performance [7].
• Practice effects were detected on six LNNB scales as well as on the HRB complex problem solving tests (Category and Tactual Performance Test) [8].
• This article highlights trends that show the influence of age, education, IQ, gender, and alcohol abuse on Halstead-Reitan Neuropsychological Test Battery (HRB) performance [9].
• To this end, a variety of haptic tasks, including three subtests of the Halstead-Reitan Neuropsychological Test Battery (HRB), were administered to 108 participants, along with established markers commonly employed in contemporary psychometric investigations [10].

High impact information on HRB

• This hRIP protein has homology with nucleoporins, a class of proteins that mediate nucleocytoplasmic transport [11].
• Here we ablate hRIP activity with a dominant-negative mutant or RNA interference and analyze Rev function by RNA in situ hybridization [2].
• We demonstrated coimmunoprecipitation of Eps15 with NUMB and RAB [12].
• Here, it is shown that iron induces ferritin and RAB (Responsive to Abscisic Acid) mRNA accumulation relatively with abscisic acid (ABA) accumulation [13].
• One of the most exciting recent discoveries is the preferential localization of vesicles of the trans-Golgi network (TGN), defined by specific RAB GTPases, in the apical 'clear zone' and the definition of TGN as a bona fide organelle involved in both polarized secretion and endocytosis [14].

Chemical compound and disease context of HRB

• The effect of ciprofloxacin and two mar RAB inducers on the susceptibility to beta-lactam antibiotics in two AmpC beta-lactamase semi-constitutive producer Citrobacter freundii clinical isolates (the DM 1 and DM 2 strains) was studied [15].

Biological context of HRB

• In this study, we have identified a new Rev-interacting protein, that specifically interacts with the Rev nuclear export signal both in yeast and mammalian cells [16].
• The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36 [17].
• Because hRIP is not required for cell viability, it may be an attractive target for the development of new antiviral strategies [18].
• The repertoire of HRB proteins did not change significantly during embryogenesis and was similar to that observed in Drosophila tissue culture cells [19].
• The peak of poly(A)+ RNA sequences was coincident with the peak of HRB proteins in sucrose gradients, strongly suggesting that the HRB complexes identified are Drosophila hnRNP complexes [19].

Anatomical context of HRB

• We further show that depletion of endogenous hRIP by RNA interference results in the loss of viral replication in human cell lines and primary macrophages; virus production was restored to wild-type levels after reintroduction of hRIP protein [18].
• In addition to hRIP, these NESs also bind to several nuclear pore complex (NPC) [20].
• These proteins have been localized to many different intracellular organelles, on both endocytic and exocytic compartments, suggesting that each step of vesicular traffic can involve a specific RAB protein [21].
• The small monomeric GTP-binding proteins of the RAB subfamily are key regulatory elements of the machinery that controls membrane traffic in eukaryotic cells [21].
• RAB GTPases help to maintain the fidelity of membrane trafficking events by recruiting cytosolic tethering and motility factors to vesicle and organelle membranes [22].

Associations of HRB with chemical compounds

• An optimal buffer is HRB containing 10 mM Tris-HCl, pH 7.4, 200 microgram/ml albumin, 10 mM MgCl2, and 100 mM NaCl [23].
• In conclusion, two mar RAB inducers and ciprofloxacin induced the Mar phenotype and repressed AmpC beta-lactamase synthesis in the DM 1 and DM 2 clinical isolates [15].
• These relatively low molecular weight proteins are usually grouped into four subfamilies, termed true RAS, RAS-like, RHO, and RAB/YPT, based on the presence of shared amino acid sequence motifs in addition to those involved in guanine nucleotide binding [24].
• The crystallographic analysis has revealed that the GTP-dissociation inhibitor of RAB GTPases has a folding topology remarkably similar to p-hydroxybenzoate hydroxylase [25].
• Changes in cardiac dynamics were analyzed by means of radiocardiographic function analysis under an infusion of epinephrine using the method of RAB [26].

Regulatory relationships of HRB

• A peptide inhibitor derived from the C-terminal heptad repeat region (HRB) was shown to potently inhibit syncytin-mediated cell fusion [27].

Other interactions of HRB

• We show here that NLP-1, like the previously described Rev-interacting protein hRIP/Rab and several nucleoporins, also interacts with CRM-1 both in yeast and mammalian cells [16].
• The objectives were to evaluate the reliability and validity of a revised RAB version (RAB-R) [3].
• This action depends on the mutationally defined Rev activation domain, which both binds the nucleoporin-like human cellular cofactor Rab/hRIP and also functions as a nuclear export signal [28].
• Altogether these results suggest that HRB is involved in clathrin-dependent endocytosis and recruits TI-VAMP in this process [29].

Analytical, diagnostic and therapeutic context of HRB

• A human Rev-interacting protein (hRIP) was originally identified based on its ability to interact with the Rev nuclear export signal (NES) in yeast two-hybrid assays [2].
• RT-PCR study revealed that RABC, RAB, RBC, RB, and R0 isoforms were expressed in thymocytes while any of RAC, RA, or RC isoforms were not detected [30].
• Insufficient information is available to draw firm conclusions of significant differences between the SHS and either the RAB, the Pugh, the Medoff or the Gotfried plates, or an external fixator [31].

References