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Gene Review

AGFG1  -  ArfGAP with FG repeats 1

Homo sapiens

Synonyms: Arf-GAP domain and FG repeat-containing protein 1, HIV-1 Rev-binding protein, HRB, Nucleoporin-like protein RIP, RAB, ...
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Disease relevance of HRB

  • The other three genes were annexin XI, human HIV Rev-interacting protein Rip-1, and the human homologue of the ATP-binding arsA component of the bacterial arsenite transporter, all of which are known to be widely expressed in human tissues [1].
  • Thus, hRIP is an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export: movement of RNAs from the nuclear periphery to the cytoplasm [2].
  • The Rating of Anorexia and Bulimia interview (RAB) is a Swedish semi-structured interview for clinical and research purposes for a wide range of eating disorder symptoms and related psychopathology [3].
  • A total of 157 postmenopausal women aged over 60 years with osteoporosis were divided into five groups according to their postural deformities: round back (RB, n=41), hollow round back (HRB, n=33), whole kyphosis (WK, n=40), lower acute kyphosis (LAK, n=18), and normal posture (NP, n=25) [4].
  • In the current study, which included a large sample (N = 369) of patients referred for neuropsychological (NP) evaluation after presumptive head injury, MMPI-2 measures of psychological disturbance accounted for as much as 25% of the variance in HRB test scores, resulting in a moderate overall effect size (median Adj. R(2) = .16; R = .40) [5].

Psychiatry related information on HRB

  • The results indicated significant effects for age and education on many of the tests, with smaller but statistically significant relationships between the quality of HRB test performance and MMPI scores [6].
  • Recently, Tremont, Hoffman, Scott, and Adams (1998) demonstrated an association between Halstead-Reitan (HRB) and Wechsler Memory Scale (WMS) performance and WAIS-R IQ scores, and recommended that premorbid intellectual estimates be utilized as general indicators of expected neuropsychological test performance [7].
  • Practice effects were detected on six LNNB scales as well as on the HRB complex problem solving tests (Category and Tactual Performance Test) [8].
  • This article highlights trends that show the influence of age, education, IQ, gender, and alcohol abuse on Halstead-Reitan Neuropsychological Test Battery (HRB) performance [9].
  • To this end, a variety of haptic tasks, including three subtests of the Halstead-Reitan Neuropsychological Test Battery (HRB), were administered to 108 participants, along with established markers commonly employed in contemporary psychometric investigations [10].

High impact information on HRB


Chemical compound and disease context of HRB

  • The effect of ciprofloxacin and two mar RAB inducers on the susceptibility to beta-lactam antibiotics in two AmpC beta-lactamase semi-constitutive producer Citrobacter freundii clinical isolates (the DM 1 and DM 2 strains) was studied [15].

Biological context of HRB


Anatomical context of HRB

  • We further show that depletion of endogenous hRIP by RNA interference results in the loss of viral replication in human cell lines and primary macrophages; virus production was restored to wild-type levels after reintroduction of hRIP protein [18].
  • In addition to hRIP, these NESs also bind to several nuclear pore complex (NPC) [20].
  • These proteins have been localized to many different intracellular organelles, on both endocytic and exocytic compartments, suggesting that each step of vesicular traffic can involve a specific RAB protein [21].
  • The small monomeric GTP-binding proteins of the RAB subfamily are key regulatory elements of the machinery that controls membrane traffic in eukaryotic cells [21].
  • RAB GTPases help to maintain the fidelity of membrane trafficking events by recruiting cytosolic tethering and motility factors to vesicle and organelle membranes [22].

Associations of HRB with chemical compounds

  • An optimal buffer is HRB containing 10 mM Tris-HCl, pH 7.4, 200 microgram/ml albumin, 10 mM MgCl2, and 100 mM NaCl [23].
  • In conclusion, two mar RAB inducers and ciprofloxacin induced the Mar phenotype and repressed AmpC beta-lactamase synthesis in the DM 1 and DM 2 clinical isolates [15].
  • These relatively low molecular weight proteins are usually grouped into four subfamilies, termed true RAS, RAS-like, RHO, and RAB/YPT, based on the presence of shared amino acid sequence motifs in addition to those involved in guanine nucleotide binding [24].
  • The crystallographic analysis has revealed that the GTP-dissociation inhibitor of RAB GTPases has a folding topology remarkably similar to p-hydroxybenzoate hydroxylase [25].
  • Changes in cardiac dynamics were analyzed by means of radiocardiographic function analysis under an infusion of epinephrine using the method of RAB [26].

Regulatory relationships of HRB

  • A peptide inhibitor derived from the C-terminal heptad repeat region (HRB) was shown to potently inhibit syncytin-mediated cell fusion [27].

Other interactions of HRB


Analytical, diagnostic and therapeutic context of HRB

  • A human Rev-interacting protein (hRIP) was originally identified based on its ability to interact with the Rev nuclear export signal (NES) in yeast two-hybrid assays [2].
  • RT-PCR study revealed that RABC, RAB, RBC, RB, and R0 isoforms were expressed in thymocytes while any of RAC, RA, or RC isoforms were not detected [30].
  • Insufficient information is available to draw firm conclusions of significant differences between the SHS and either the RAB, the Pugh, the Medoff or the Gotfried plates, or an external fixator [31].


  1. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. Güre, A.O., Altorki, N.K., Stockert, E., Scanlan, M.J., Old, L.J., Chen, Y.T. Cancer Res. (1998) [Pubmed]
  2. hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region. Sánchez-Velar, N., Udofia, E.B., Yu, Z., Zapp, M.L. Genes Dev. (2004) [Pubmed]
  3. A measure for the assessment of eating disorders: reliability and validity studies of the Rating of Anorexia and Bulimia interview - revised version (RAB-R). Nevonen, L., Broberg, A.G., Clinton, D., Norring, C. Scandinavian journal of psychology. (2003) [Pubmed]
  4. Impact of postural deformities and spinal mobility on quality of life in postmenopausal osteoporosis. Miyakoshi, N., Itoi, E., Kobayashi, M., Kodama, H. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2003) [Pubmed]
  5. Psychological disturbance, incomplete effort, and compensation-seeking status as predictors of neuropsychological test performance in head injury. Ross, S.R., Putnam, S.H., Adams, K.M. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (2006) [Pubmed]
  6. Emotional variables and neuropsychological test performance. Gass, C.S. Journal of clinical psychology. (1991) [Pubmed]
  7. Association between IQ and neuropsychological test performance: commentary on Tremont, Hoffman, Scott, and Adams (1998). Larrabee, G.J. The Clinical neuropsychologist. (2000) [Pubmed]
  8. The Luria-Nebraska and Halstead-Reitan Neuropsychological Test batteries: a cross-cultural study in English and Arabic. el-Sheikh, M., el-Nagdy, S., Townes, B.D., Kennedy, M.C. Int. J. Neurosci. (1987) [Pubmed]
  9. The influence of age, education, IQ, gender, and alcohol abuse on Halstead-Reitan Neuropsychological Test Battery performance. Leckliter, I.N., Matarazzo, J.D. Journal of clinical psychology. (1989) [Pubmed]
  10. Biological versus psychometric intelligence: Halstead's (1947) distinction revisited. Pallier, G., Roberts, R.D., Stankov, L. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. (2000) [Pubmed]
  11. A human nucleoporin-like protein that specifically interacts with HIV Rev. Fritz, C.C., Zapp, M.L., Green, M.R. Nature (1995) [Pubmed]
  12. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Salcini, A.E., Confalonieri, S., Doria, M., Santolini, E., Tassi, E., Minenkova, O., Cesareni, G., Pelicci, P.G., Di Fiore, P.P. Genes Dev. (1997) [Pubmed]
  13. Abscisic acid is involved in the iron-induced synthesis of maize ferritin. Lobréaux, S., Hardy, T., Briat, J.F. EMBO J. (1993) [Pubmed]
  14. Vesicular trafficking, cytoskeleton and signalling in root hairs and pollen tubes. Samaj, J., M??ller, J., Beck, M., B??hm, N., Menzel, D. Trends Plant Sci. (2006) [Pubmed]
  15. Ciprofloxacin, salicylate, and 2,4-dinitrophenol decrease production of AmpC-type beta-lactamase in two Citrobacter freundii clinical isolates. Tavío, M.M., Perilli, M., Vila, J., Becerro, P., Ruiz, J., Amicosante, G., De Anta, M.T. Microb. Drug Resist. (2005) [Pubmed]
  16. A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. Farjot, G., Sergeant, A., Mikaélian, I. J. Biol. Chem. (1999) [Pubmed]
  17. The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36. Jones, T., Sheer, D., Bevec, D., Kappel, B., Hauber, J., Steinkasserer, A. Genomics (1997) [Pubmed]
  18. The cellular HIV-1 Rev cofactor hRIP is required for viral replication. Yu, Z., Sánchez-Velar, N., Catrina, I.E., Kittler, E.L., Udofia, E.B., Zapp, M.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  19. Heterogeneous nuclear ribonucleoprotein complexes and proteins in Drosophila melanogaster. Raychaudhuri, G., Haynes, S.R., Beyer, A.L. Mol. Cell. Biol. (1992) [Pubmed]
  20. HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. Fritz, C.C., Green, M.R. Curr. Biol. (1996) [Pubmed]
  21. Trypanosoma cruzi: cloning and characterization of a RAB7 gene. Leal, S.T., Araripe, J.R., Urményi, T.P., Cross, G.A., Rondinelli, E. Exp. Parasitol. (2000) [Pubmed]
  22. Assay and properties of rab6 interaction with dynein-dynactin complexes. Fuchs, E., Short, B., Barr, F.A. Meth. Enzymol. (2005) [Pubmed]
  23. Site-specific endonuclease NspLKI is an isoschizomer of endonuclease HaeIII. Zabaznaya, E.V., Zheleznaya, L.A., Svad'bina, I.V., Matvienko, N.I. Biochemistry Mosc. (1999) [Pubmed]
  24. Evolutionary grouping of the RAS-protein family. Drivas, G.T., Palmieri, S., D'Eustachio, P., Rush, M.G. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  25. The PHBH fold: not only flavoenzymes. Mattevi, A. Biophys. Chem. (1998) [Pubmed]
  26. About the possibilities of registration of drug influence by means of radiocardiographic function analysis. Lösel, E., Kleine, N., Hoffmann, G. Nuklearmedizin. (1981) [Pubmed]
  27. Functional characterization of the placental fusogenic membrane protein syncytin. Chang, C., Chen, P.T., Chang, G.D., Huang, C.J., Chen, H. Biol. Reprod. (2004) [Pubmed]
  28. Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. Fridell, R.A., Bogerd, H.P., Cullen, B.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  29. Role of HRB in clathrin-dependent endocytosis. Chaineau, M., Danglot, L., Proux-Gillardeaux, V., Galli, T. J. Biol. Chem. (2008) [Pubmed]
  30. A study on CD45 isoform expression during T-cell development and selection events in the human thymus. Fukuhara, K., Okumura, M., Shiono, H., Inoue, M., Kadota, Y., Miyoshi, S., Matsuda, H. Hum. Immunol. (2002) [Pubmed]
  31. Extramedullary fixation implants and external fixators for extracapsular hip fractures. Parker, M.J., Handoll, H.H. Cochrane database of systematic reviews (Online) (2002) [Pubmed]
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