Disease relevance of Kyphosis

• Mice nullizygous at the Neu1 locus develop clinical abnormalities reminiscent of early-onset sialidosis in children, including severe nephropathy, progressive edema, splenomegaly, kyphosis and urinary excretion of sialylated oligosaccharides [1].
• METHODS: Over a period of 5 yr, 413 control subjects without a history of back pain, scoliosis, kyphosis, joint pain, arthritis, lesions within the pelvis, chemotherapy or systemic disease such as diabetes or systemic lupus erythematosus were included in this study [2].
• Early loss of estrogen in the null mutants leads to obesity and skeletal abnormalities that intensify with age producing (kyphosis), a hunchback appearance [3].
• These findings suggest that the reproductive postures of female rats, lordosis and kyphosis, as well as sexual solicitations, are tonically inhibited by the neurotransmitter GABA within the ventrolateral caudal periaqueductal gray in the midbrain [4].
• One of them also had a marfanoid habitus, thoracic kyphosis, and arachnodactyly, and was heterozygous for alpha 1 antitrypsin deficiency [5].

Psychiatry related information on Kyphosis

• The phenotype of the patient was severe, including joint stiffness, kyphosis, hepatomegaly, hypertrophic cardiomyopathy, moderate mental retardation, and bilateral hearing loss [6].

High impact information on Kyphosis

• These mice appeared normal and exhibited normal motor function for about 6 weeks, but then developed a progressive neurological disease that includes many features of RTT: tremors, motor impairments, hypoactivity, increased anxiety-related behavior, seizures, kyphosis, and stereotypic forelimb motions [7].
• Kyphosis was very prevalent among a community whose drinking water contained 7.4 mg/l fluoride [8].
• Transgenic mice with elevated plasma BNP concentrations exhibited deformed bony skeletons characterized by kyphosis, elongated limbs and paws, and crooked tails [9].
• This report describes the first published clinical account of a case of ankylosing spondylitis in the United States. The patient progressively developed very severe kyphosis with resultant severe disability [10].
• Between 1988 and 1991, BMD of the hip and spine and kyphosis were measured [11].

Chemical compound and disease context of Kyphosis

• Ibandronate treatment was well tolerated, and biochemical markers of bone turnover suppressed to within the age-appropriate normal range There was some progression of her thoracic kyphosis, but she had no further fractures and remained mobile and active at an age when her siblings had become wheelchair-bound [12].
• Standard coronal magnetic resonance (MR) imaging cannot depict long segments of the tracheobronchial tree and left pulmonary artery owing to the normal thoracic kyphosis and posteriorly angled course of these structures [13].
• Neuroradiological examination revealed severe spinal cord compression from kyphosis at the C3 level [14].
• RESULTS: Kyphosis correction was achieved in Group A (PMMA vertebroplasty) and Group B (Group A, 6.4 degrees; Group B, 5.4 degrees) [15].
• Three angles describing sagittal alignment were investigated: 1) forward inclination of C2 relative to C7 (cervical inclination); 2) cervicothoracic kyphosis; and 3) cervical lordosis [16].

Biological context of Kyphosis

• We describe the musculoskeletal development of 11 of the 12 surviving children and the orthopaedic procedures undertaken to treat progressive thoracolumbar kyphosis, hip subluxation and carpal tunnel syndrome [17].
• A high incidence of fractures and kyphosis in the continually increasing adult patient population and in post-lung transplant patients has highlighted the problems associated with poor bone health.The aetiology of osteoporosis in CF is multifactorial but centres on an uncoupling in the normal balance between bone formation and resorption [18].
• Lordosis from L1 to S1, kyphosis from T10 to L1, and the changes seen moving from the supine position to standing were calculated [19].

Anatomical context of Kyphosis

• Estrogen suppressed the spinal growth and the progression of kyphosis in both sexes, and accelerated narrowing of the epiphyseal plates, which became apparent at 6 weeks after birth in females and 8 weeks in males [20].
• OBJECTIVES: To document sagittal translation (ST) of the vertebral column in opening wedge osteotomy (OWO) for ankylosing spondylitis (AS) kyphosis [21].
• The elevation of the endofrontal eminence relative to the sphenoid planum was higher in skulls with increased cranial base kyphosis, whereas reduced sphenoid angle was associated with an increase in the elevations of the endofrontal eminence [22].
• Although vascular compression of the duodenum with subsequent nausea and vomiting and electrolyte imbalance, caused by the relative lengthening of the spine, is most commonly associated with surgical correction of coronal plane deformities (ie, scoliosis), it may occur in patients undergoing correction of thoracic kyphosis as well [23].
• CONCLUSIONS: These findings suggest that higher PI in the younger individual may contribute to the development of HOA in later life without both lumbar kyphosis and acetabular dysplasia because of the anterior uncovering of the acetabulum [24].

Gene context of Kyphosis

• In addition, the older sister has KS, together with synkinesia and multiple skeletal abnormalities, mainly kyphosis, vertebral abnormalities, and short right hand and feet [25].
• The motor deficits appear to be a direct and predicted consequence of the skeletal kyphosis, scoliosis and long bone overgrowth previously reported in Fgfr3 null mutant mice [26].
• Progression of kyphosis in mdx mice [27].
• Resorptive lesions localized to the lower thoracic and upper lumbar vertebral bodies, collapse and angular kyphosis, resulting from complete destruction of T11 and T12 and partial destruction of T10 and L1, are the main pathologic features [28].
• The apex level of kyphosis was T5 in one patient, T11 in one, and T12 in five [29].

Analytical, diagnostic and therapeutic context of Kyphosis

• Osteotomy for kyphosis in ankylosing spondylitis [30].
• STUDY DESIGN: This is a retrospective study of surgical correction of thoracolumbar kyphosis caused by ankylosing spondylitis [31].
• SUMMARY OF BACKGROUND DATA: Resection of the C2 lamina was reported to progress to kyphosis after laminectomy [32].

References