Gene Review:
TRIB3 - tribbles pseudokinase 3
Homo sapiens
Synonyms:
C20orf97, NIPK, SINK, SKIP3, TRB-3, ...
Prudente,
Hribal,
Flex,
Turchi,
Morini,
De Cosmo,
Bacci,
Tassi,
Cardellini,
Lauro,
Sesti,
Dallapiccola,
Trischitta,
- SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. Bowers, A.J., Scully, S., Boylan, J.F. Oncogene (2003)
- The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. Prudente, S., Hribal, M.L., Flex, E., Turchi, F., Morini, E., De Cosmo, S., Bacci, S., Tassi, V., Cardellini, M., Lauro, R., Sesti, G., Dallapiccola, B., Trischitta, V. Diabetes (2005)
- TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Du, K., Herzig, S., Kulkarni, R.N., Montminy, M. Science (2003)
- TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. Schwarzer, R., Dames, S., Tondera, D., Klippel, A., Kaufmann, J. Cell. Signal. (2006)
- TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K., Hayashi, H. EMBO J. (2005)
- Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3. Koh, H.J., Arnolds, D.E., Fujii, N., Tran, T.T., Rogers, M.J., Jessen, N., Li, Y., Liew, C.W., Ho, R.C., Hirshman, M.F., Kulkarni, R.N., Kahn, C.R., Goodyear, L.J. Mol. Cell. Biol. (2006)
- Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. Ord, D., Ord, T. Biochem. Biophys. Res. Commun. (2005)
- Fibrates upregulate TRB3 in lymphocytes independent of PPARalpha by augmenting CCAAT/enhancer-binding proteinbeta (C/EBPbeta) expression. Selim, E., Frkanec, J.T., Cunard, R. Mol. Immunol. (2007)
- TRB3 interacts with CtIP and is overexpressed in certain cancers. Xu, J., Lv, S., Qin, Y., Shu, F., Xu, Y., Chen, J., Xu, B.E., Sun, X., Wu, J. Biochim. Biophys. Acta (2007)
- PGC-1{alpha} and PGC-1beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype. Mortensen, O.H., Frandsen, L., Schjerling, P., Nishimura, E., Grunnet, N. Am. J. Physiol. Endocrinol. Metab. (2006)
- TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Qi, L., Heredia, J.E., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I.X., Liew, C.W., Kulkarni, R.N., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J., Montminy, M. Science (2006)
- Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Carracedo, A., Gironella, M., Lorente, M., Garcia, S., Guzmán, M., Velasco, G., Iovanna, J.L. Cancer Res. (2006)
- Identification of a novel kinase-like gene induced during neuronal cell death. Mayumi-Matsuda, K., Kojima, S., Suzuki, H., Sakata, T. Biochem. Biophys. Res. Commun. (1999)
- Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression. Corcoran, C.A., Luo, X., He, Q., Jiang, C., Huang, Y., Sheikh, M.S. Cancer Biol. Ther. (2005)