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Gene Review

gtfD  -  glucosyltransferase-S

Streptococcus mutans UA159

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Disease relevance of gtfD


High impact information on gtfD

  • Apigenin (0.1 mM) significantly decreased the expression of gtfB and gtfC mRNA (P < 0.05); in contrast, it increased the expression of gtfD in S. mutans growing in the planktonic state [3].
  • In the present study, we investigated the influence of apigenin on gtfB, gtfC, and gtfD expression in S. mutans UA159 [3].
  • The results of Northern hybridization and/or real-time reverse transcription-PCR experiments reveal increased expression of both Gtf-S and glucan binding protein C (GbpC) in a tarC knockout mutant (GMS900), thereby supporting the notion that TarC acts as a negative transcriptional regulator [4].
  • Insertional inactivation of the gtfD gene indicated that this gene is not required for in vitro sucrose-dependent adherence to smooth surfaces [1].
  • The resultant plasmid, pNH4, expressed glucosyltransferase S (GTF-S) activity [1].

Chemical compound and disease context of gtfD


Biological context of gtfD


Associations of gtfD with chemical compounds

  • Furthermore, inactivation of the gtfD gene in a gtfC gtfB mutant indicated that three distinct gtf genes involved in glucan formation are present on the S. mutans GS-5 chromosome [1].
  • These findings support the involvement of Cu(2+) as an effector molecule in the regulation of S. mutans gtfD [10].
  • In the present study, the levels of expression of the gtfB, gtfC, gtfD and ftf genes coding for polysaccharide-synthesizing enzymes in strain Xc100L were compared with those in strain Xc [11].

Other interactions of gtfD

  • Our findings show that dietary carbohydrates have a major influence on the transcription of ftf, gtfB, gtfC and gtfD, but less on vicR [12].

Analytical, diagnostic and therapeutic context of gtfD


  1. Isolation and characterization of the Streptococcus mutans gtfD gene, coding for primer-dependent soluble glucan synthesis. Hanada, N., Kuramitsu, H.K. Infect. Immun. (1989) [Pubmed]
  2. Regulation of the gtfBC and ftf genes of Streptococcus mutans in biofilms in response to pH and carbohydrate. Li, Y., Burne, R.A. Microbiology (Reading, Engl.) (2001) [Pubmed]
  3. Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. Koo, H., Seils, J., Abranches, J., Burne, R.A., Bowen, W.H., Quivey, R.G. Antimicrob. Agents Chemother. (2006) [Pubmed]
  4. Effect of an orphan response regulator on Streptococcus mutans sucrose-dependent adherence and cariogenesis. Idone, V., Brendtro, S., Gillespie, R., Kocaj, S., Peterson, E., Rendi, M., Warren, W., Michalek, S., Krastel, K., Cvitkovitch, D., Spatafora, G. Infect. Immun. (2003) [Pubmed]
  5. Differential and quantitative analyses of mRNA expression of glucosyltransferases from Streptococcus mutans MT8148. Fujiwara, T., Hoshino, T., Ooshima, T., Hamada, S. J. Dent. Res. (2002) [Pubmed]
  6. Cariogenicity of Streptococcus mutans V403 glucosyltransferase and fructosyltransferase mutants constructed by allelic exchange. Munro, C., Michalek, S.M., Macrina, F.L. Infect. Immun. (1991) [Pubmed]
  7. Primer extension analysis of Streptococcus mutans promoter structures. Smorawinska, M., Kuramitsu, H.K. Oral Microbiol. Immunol. (1995) [Pubmed]
  8. Nucleotide sequence of the Streptococcus mutans gtfD gene encoding the glucosyltransferase-S enzyme. Honda, O., Kato, C., Kuramitsu, H.K. J. Gen. Microbiol. (1990) [Pubmed]
  9. Purification of glucosyltransferases (GtfB/C and GtfD) from mutant strains of Streptococcus mutans. Chia, J.S., Hsieh, C.C., Yang, C.S., Chen, J.Y. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi (1995) [Pubmed]
  10. Differential regulation of Streptococcus mutans gtfBCD genes in response to copper ions. Chen, P.M., Chen, J.Y., Chia, J.S. Arch. Microbiol. (2006) [Pubmed]
  11. Molecular and genetic analysis of multiple changes in the levels of production of virulence factors in a subcultured variant of Streptococcus mutans. Yamashita, Y., Tsukioka, Y., Nakano, Y., Shibata, Y., Koga, T. FEMS Microbiol. Lett. (1996) [Pubmed]
  12. Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases. Shemesh, M., Tam, A., Feldman, M., Steinberg, D. Carbohydr. Res. (2006) [Pubmed]
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