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Gene Review

CRIP2  -  cysteine-rich protein 2

Homo sapiens

Synonyms: CRIP, CRP-2, CRP2, Cysteine-rich protein 2, ESP1, ...
 
 
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Disease relevance of CRIP2

 

High impact information on CRIP2

 

Chemical compound and disease context of CRIP2

  • Three other Cys-rich proteins, papilloma viral E7 and LIM motif-containing CRP and CRIP, isolated as Zn2+ proteins exhibit facile metal exchange in vitro with Cu1+ [9].
 

Biological context of CRIP2

 

Anatomical context of CRIP2

 

Associations of CRIP2 with chemical compounds

 

Analytical, diagnostic and therapeutic context of CRIP2

  • Western blot analysis revealed a more restricted expression pattern for CRIP2 with high expression in lung, heart and brain [10].
  • A longitudinal study of a heterosexual couple infected with group O (ESP1 and ESP2) allowed a detailed analysis of RT sequences (amino acids 28 to 219) [18].

References

  1. A cell surface marker gene transferred with a retroviral vector into CD34+ cord blood cells is expressed by their T-cell progeny in the SCID-hu thymus. Champseix, C., Maréchal, V., Khazaal, I., Schwartz, O., Fournier, S., Schlegel, N., Dranoff, G., Danos, O., Blot, P., Vilmer, E., Heard, J.M., Péault, B., Lehn, P. Blood (1996) [Pubmed]
  2. Retrovirus-mediated gene transfer and expression of human ornithine delta-aminotransferase into embryonic fibroblasts. Rivero, J.L., Lacorazza, H.D., Kozhich, A., Nussenblatt, R.B., Jendoubi, M. Hum. Gene Ther. (1994) [Pubmed]
  3. Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection. Shankar, N., Lockatell, C.V., Baghdayan, A.S., Drachenberg, C., Gilmore, M.S., Johnson, D.E. Infect. Immun. (2001) [Pubmed]
  4. The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas. Harada, T., Nishie, A., Torigoe, K., Ikezaki, K., Shono, T., Maehara, Y., Kuwano, M., Wada, M. Jpn. J. Cancer Res. (2000) [Pubmed]
  5. CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. Williams, S.C., Baer, M., Dillner, A.J., Johnson, P.F. EMBO J. (1995) [Pubmed]
  6. Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders. Hawkins, R.D., Bashiardes, S., Helms, C.A., Hu, L., Saccone, N.L., Warchol, M.E., Lovett, M. Hum. Mol. Genet. (2003) [Pubmed]
  7. Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo. Nagashima, S., Mailliard, R., Kashii, Y., Reichert, T.E., Herberman, R.B., Robbins, P., Whiteside, T.L. Blood (1998) [Pubmed]
  8. KIN241: a gene involved in cell morphogenesis in Paramecium tetraurelia reveals a novel protein family of cyclophilin-RNA interacting proteins (CRIPs) conserved from fission yeast to man. Krzywicka, A., Beisson, J., Keller, A.M., Cohen, J., Jerka-Dziadosz, M., Klotz, C. Mol. Microbiol. (2001) [Pubmed]
  9. The metallothionein structural motif in gene expression. Winge, D.R., Dameron, C.T., George, G.N. Adv. Inorg. Biochem. (1994) [Pubmed]
  10. Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. van Ham, M., Croes, H., Schepens, J., Fransen, J., Wieringa, B., Hendriks, W. Genes Cells (2003) [Pubmed]
  11. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Karim, M.A., Ohta, K., Egashira, M., Jinno, Y., Niikawa, N., Matsuda, I., Indo, Y. Genomics (1996) [Pubmed]
  12. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2. Weiskirchen, R., Erdel, M., Utermann, G., Bister, K. Genomics (1997) [Pubmed]
  13. Complement and anti-alpha-galactosyl natural antibody-mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum. Agrawal, R.S., Karhu, K., Laukkanen, J., Kirkinen, P., Ylä-Herttuala, S., Agrawal, Y.P. Gene Ther. (1999) [Pubmed]
  14. Cysteine-rich intestinal protein (CRIP): a new intestinal zinc transport protein. O'Dell, B.L. Nutr. Rev. (1992) [Pubmed]
  15. Vitamin D-sensitive and quinacrine-sensitive zinc transport in human intestinal cell line Caco-2. Fleet, J.C., Turnbull, A.J., Bourcier, M., Wood, R.J. Am. J. Physiol. (1993) [Pubmed]
  16. Positive regulation of the colicin E1 gene by cyclic AMP and cyclic AMP receptor protein. Shirabe, K., Ebina, Y., Miki, T., Nakazawa, T., Nakazawa, A. Nucleic Acids Res. (1985) [Pubmed]
  17. Electrostatic potential of nucleotide-free protein is sufficient for discrimination between adenine and guanine-specific binding sites. Basu, G., Sivanesan, D., Kawabata, T., Go, N. J. Mol. Biol. (2004) [Pubmed]
  18. Analysis of pol gene heterogeneity, viral quasispecies, and drug resistance in individuals infected with group O strains of human immunodeficiency virus type 1. Quiñones-Mateu, M.E., Albright, J.L., Mas, A., Soriano, V., Arts, E.J. J. Virol. (1998) [Pubmed]
 
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