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Gene Review

AHSA1  -  AHA1, activator of heat shock 90kDa...

Homo sapiens

Synonyms: AHA1, Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322, p38
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Disease relevance of AHSA1


High impact information on AHSA1

  • Colabeling with cell-specific markers revealed that macrophages expressed the alpha and gamma isoforms, synovial fibroblasts the beta and gamma isoforms, and granulocytes the delta isoform, whereas T lymphocytes were rarely positive for any p38 MAPK isoform [4].
  • By immunohistochemistry, the expression of all p38 MAPK isoforms was localized to the synovial lining layer as well as to blood vessels [4].
  • This phosphorylation pattern was confirmed in immunoprecipitation studies in which activated p38 MAPK from synovial tissue extracts was identified as p38 MAPKalpha and -gamma but not p38 MAPKbeta or -delta [4].
  • Preliminary evidence suggests that p38 may interact transiently with endoplasmic reticulum (ER) membranes, and thus may affect VSV G and other cargo movement at the step of ER to Golgi traffic [1].

Analytical, diagnostic and therapeutic context of AHSA1


  1. p38: A novel protein that associates with the vesicular stomatitis virus glycoprotein. Sevier, C.S., Machamer, C.E. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis. Wang, X., Venable, J., Lapointe, P., Hutt, D.M., Koulov, A.V., Coppinger, J., Gurkan, C., Kellner, W., Matteson, J., Plutner, H., Riordan, J.R., Kelly, J.W., Yates, J.R., Balch, W.E. Cell (2006) [Pubmed]
  3. Leishmania infecting man and wild animals in Saudi Arabia. 3. Leishmaniasis in Psammomys obesus Cretzschmar in Al-Ahsa oasis. Elbihari, S., Kawasmeh, Z.A., Al-Naiem, A., Al-Atiya, S. Trop. Med. Parasitol. (1987) [Pubmed]
  4. Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis. Korb, A., Tohidast-Akrad, M., Cetin, E., Axmann, R., Smolen, J., Schett, G. Arthritis Rheum. (2006) [Pubmed]
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