Disease relevance of AHSA1

• p38: A novel protein that associates with the vesicular stomatitis virus glycoprotein [1].
• Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis [2].
• Zoonotic cutaneous leishmaniasis (ZCL) is hyperenzootic in Psammomys obesus in Al-Ahsa oasis in Saudi Arabia: 93% of 202 specimens of this rodent examined had signs of the infection [3].
• Leishmania infecting man and wild animals in Saudi Arabia. 3. Leishmaniasis in Psammomys obesus Cretzschmar in Al-Ahsa oasis [3].

High impact information on AHSA1

• Colabeling with cell-specific markers revealed that macrophages expressed the alpha and gamma isoforms, synovial fibroblasts the beta and gamma isoforms, and granulocytes the delta isoform, whereas T lymphocytes were rarely positive for any p38 MAPK isoform [4].
• By immunohistochemistry, the expression of all p38 MAPK isoforms was localized to the synovial lining layer as well as to blood vessels [4].
• This phosphorylation pattern was confirmed in immunoprecipitation studies in which activated p38 MAPK from synovial tissue extracts was identified as p38 MAPKalpha and -gamma but not p38 MAPKbeta or -delta [4].
• Preliminary evidence suggests that p38 may interact transiently with endoplasmic reticulum (ER) membranes, and thus may affect VSV G and other cargo movement at the step of ER to Golgi traffic [1].

Analytical, diagnostic and therapeutic context of AHSA1

• The expression and activation of the alpha, beta, gamma, and delta isoforms of p38 MAPK were examined by immunoblotting, immunoprecipitation, and immunohistochemistry [4].

References