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Gene Review

MAP3K2  -  mitogen-activated protein kinase kinase...

Homo sapiens

Synonyms: MAPK/ERK kinase kinase 2, MAPKKK2, MEK kinase 2, MEKK 2, MEKK2, ...
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High impact information on MAP3K2


Biological context of MAP3K2


Associations of MAP3K2 with chemical compounds


Regulatory relationships of MAP3K2

  • Furthermore, MEKK2 immunoprecipitates activated c-Jun in an IL-1 dependent manner and this activity was inhibited by the selective JNK inhibitor SP600125 [6].

Other interactions of MAP3K2

  • No scaffold protein was required for the MEKK2-JNKK2-JNK1 tripartite-complex formation [7].
  • Moreover, both MEKK2 and MEKK3 coimmunoprecipitated with endogenous WNK1 from cell lysates [8].
  • WNK1 activates ERK5 by an MEKK2/3-dependent mechanism [8].
  • The biological roles of MEKK2, 3 and 4 are under investigation and undoubtedly homologous deletion of these MEKK family members will be invaluable at determining the biological functions of these MEKKs [9].
  • In contrast, MEKK2 and PKA also increased shedding of TNF receptor 2, suggesting that these kinases contribute to a general program regulating ectodomain shedding [10].


  1. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways. Zhang, D., Facchinetti, V., Wang, X., Huang, Q., Qin, J., Su, B. EMBO J. (2006) [Pubmed]
  2. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. Chayama, K., Papst, P.J., Garrington, T.P., Pratt, J.C., Ishizuka, T., Webb, S., Ganiatsas, S., Zon, L.I., Sun, W., Johnson, G.L., Gelfand, E.W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Nakamura, K., Uhlik, M.T., Johnson, N.L., Hahn, K.M., Johnson, G.L. Mol. Cell. Biol. (2006) [Pubmed]
  4. Dimerization through the catalytic domain is essential for MEKK2 activation. Cheng, J., Yu, L., Zhang, D., Huang, Q., Spencer, D., Su, B. J. Biol. Chem. (2005) [Pubmed]
  5. In vitro activity of MEKK2 and MEKK3 in detergents is a function of a valine to serine difference in the catalytic domain. Widmann, C., Sather, S., Oyer, R., Johnson, G.L., Dreskin, S.C. Biochim. Biophys. Acta (2001) [Pubmed]
  6. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. Hammaker, D.R., Boyle, D.L., Chabaud-Riou, M., Firestein, G.S. J. Immunol. (2004) [Pubmed]
  7. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Cheng, J., Yang, J., Xia, Y., Karin, M., Su, B. Mol. Cell. Biol. (2000) [Pubmed]
  8. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. Xu, B.E., Stippec, S., Lenertz, L., Lee, B.H., Zhang, W., Lee, Y.K., Cobb, M.H. J. Biol. Chem. (2004) [Pubmed]
  9. The TAO of MEKK. Schlesinger, T.K., Fanger, G.R., Yujiri, T., Johnson, G.L. Front. Biosci. (1998) [Pubmed]
  10. Expression cloning screen for modifiers of amyloid precursor protein shedding. Schöbel, S., Neumann, S., Seed, B., Lichtenthaler, S.F. Int. J. Dev. Neurosci. (2006) [Pubmed]
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