Disease relevance of FZD10

• Matched tumor/normal expression array analysis revealed significant up-regulation of FZD10 mRNA in 2 cases of primary colon cancer [1].
• Northern blot analyses revealed relatively high-level expression of 4.0-kb FZD10 mRNA in cervical cancer cell lines HeLa S3, SKG-I, SKG-IIIa, and in a glioblastoma cell line A-172 [1].
• Effects of inflammatory cytokines on FZD10 mRNA expression in a gastric cancer cell line MKN45 was next investigated [2].
• FZD10 mRNA was undetectable in MCF-7 cells derived from breast cancer, and was significantly up-regulated by beta-estradiol in MCF-7 cells with a peak at 24 h after treatment [2].
• Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas [3].

High impact information on FZD10

• By binding to an extracellular domain of frizzled homologue 10 (FZD10), HIG2 protein enhanced oncogenic Wnt signaling and its own transcription, suggesting that this product is likely to function as an autocrine growth factor [4].
• Northern blotting and immunohistochemical staining confirmed that expression levels of FZD 10 were very high in nearly all SS tumors and cell lines examined but absent in most normal organs or in some cancers arising in other tissues [3].
• Moreover, a polyclonal antibody specifically recognizing the extracellular domain (ECD) of FZD 10 was markedly effective in mediating ADCC against FZD 10-overexpressing synovial sarcoma cells in vitro [3].
• Synchronous up-regulation of FZD10 and WNT2 mRNAs might lead to activation of the WNT signaling pathway in human breast cancer [2].
• Here, effects of beta-estradiol, retinoic acid, and inflammatory cytokines on expression of FZD10 mRNA in human cancer cell lines were investigated [2].

Biological context of FZD10

• The FZD10 gene was mapped to human chromosome 12q24.33 [5].
• Nucleotide sequence analysis showed that human FZD10 gene encodes a seven-transmembrane-receptor of 581 amino acids, with the N-terminal cysteine-rich domain and the C-terminal Ser/Thr-Xxx-Val motif [5].
• FZD4 consists of two exons, while FZD9 and FZD10 consist of a single exon [6].

Associations of FZD10 with chemical compounds

• FZD10 mRNA was expressed in NT2 cells, which are reported to differentiate into neuronal cells after exposure to retinoic acid [2].

Other interactions of FZD10

• FZD4 and FZD10 are up-regulated in NT2 cells after ATRA treatment [7].
• FZD9 and FZD10 were up-regulated together in TMK1 and MKN74 [8].
• Function of FZD10 was next investigated by using Xenopus axis duplication assay, in which positive regulators of the WNT - beta-catenin - TCF signaling pathway induce axis duplication [1].
• Frizzled-10 (FZD10), a novel member of the Frizzled gene family, has been cloned and characterized [5].
• Positional/functional candidate genes in this region include frizzled 10, epimorphin, RAN, and ZFOC1 [9].

Analytical, diagnostic and therapeutic context of FZD10

• Here, expression of FZD10 mRNA in various types of human cancer and effects of FZD10 mRNA microinjection into Xenopus early embryos were investigated [1].
• Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family [5].

References