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Gene Review

FZD10  -  frizzled class receptor 10

Homo sapiens

Synonyms: CD350, FZ-10, Frizzled-10, Fz-10, Fz10, ...
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Disease relevance of FZD10


High impact information on FZD10

  • By binding to an extracellular domain of frizzled homologue 10 (FZD10), HIG2 protein enhanced oncogenic Wnt signaling and its own transcription, suggesting that this product is likely to function as an autocrine growth factor [4].
  • Northern blotting and immunohistochemical staining confirmed that expression levels of FZD 10 were very high in nearly all SS tumors and cell lines examined but absent in most normal organs or in some cancers arising in other tissues [3].
  • Moreover, a polyclonal antibody specifically recognizing the extracellular domain (ECD) of FZD 10 was markedly effective in mediating ADCC against FZD 10-overexpressing synovial sarcoma cells in vitro [3].
  • Synchronous up-regulation of FZD10 and WNT2 mRNAs might lead to activation of the WNT signaling pathway in human breast cancer [2].
  • Here, effects of beta-estradiol, retinoic acid, and inflammatory cytokines on expression of FZD10 mRNA in human cancer cell lines were investigated [2].

Biological context of FZD10


Associations of FZD10 with chemical compounds

  • FZD10 mRNA was expressed in NT2 cells, which are reported to differentiate into neuronal cells after exposure to retinoic acid [2].

Other interactions of FZD10


Analytical, diagnostic and therapeutic context of FZD10


  1. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. Terasaki, H., Saitoh, T., Shiokawa, K., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  2. Up-regulation of Frizzled-10 (FZD10) by beta-estradiol in MCF-7 cells and by retinoic acid in NT2 cells. Saitoh, T., Mine, T., Katoh, M. Int. J. Oncol. (2002) [Pubmed]
  3. Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas. Nagayama, S., Fukukawa, C., Katagiri, T., Okamoto, T., Aoyama, T., Oyaizu, N., Imamura, M., Toguchida, J., Nakamura, Y. Oncogene (2005) [Pubmed]
  4. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. Togashi, A., Katagiri, T., Ashida, S., Fujioka, T., Maruyama, O., Wakumoto, Y., Sakamoto, Y., Fujime, M., Kawachi, Y., Shuin, T., Nakamura, Y. Cancer Res. (2005) [Pubmed]
  5. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. Koike, J., Takagi, A., Miwa, T., Hirai, M., Terada, M., Katoh, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  6. Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Kirikoshi, H., Sagara, N., Koike, J., Tanaka, K., Sekihara, H., Hirai, M., Katoh, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  7. Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review). Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  8. Expression profiles of 10 members of Frizzled gene family in human gastric cancer. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  9. A novel locus for autosomal dominant non-syndromic deafness (DFNA41) maps to chromosome 12q24-qter. Blanton, S.H., Liang, C.Y., Cai, M.W., Pandya, A., Du, L.L., Landa, B., Mummalanni, S., Li, K.S., Chen, Z.Y., Qin, X.N., Liu, Y.F., Balkany, T., Nance, W.E., Liu, X.Z. J. Med. Genet. (2002) [Pubmed]
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