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Gene Review

FZD9  -  frizzled class receptor 9

Homo sapiens

Synonyms: CD349, FZD3, Frizzled-9, Fz-9, FzE6, ...
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Disease relevance of FZD9


Psychiatry related information on FZD9


High impact information on FZD9

  • FZD3 is expressed predominantly in brain, testis, eye, skeletal muscle and kidney [6].
  • By applying CpG island cloning methods to cosmids from the deletion region, we have identified a new gene, called FZD3 [6].
  • Recent studies from our laboratory indicate that combined expression of the combination of Wnt 7a and Frizzled 9 (Fzd 9) in Non-small Cell Lung Cancer (NSCLC) cell lines inhibits transformed growth [7].
  • The action of Wnt-7a correlated with expression of the specific Wnt receptor Frizzled-9 (Fzd-9), and transfection of Fzd-9 into a Wnt-7a-insensitive NSCLC cell line established Wnt-7a sensitivity [4].
  • Detection of an atypical 7q11.23 deletion in Williams syndrome patients which does not include the STX1A and FZD3 genes [8].

Chemical compound and disease context of FZD9


Biological context of FZD9


Anatomical context of FZD9

  • Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation [11].
  • In testis, Fzd9 is expressed in all spermatogenic cell types [12].

Other interactions of FZD9

  • FZD9 and FZD10 were up-regulated together in TMK1 and MKN74 [1].
  • HMEC expressed all Frizzled receptors except FZD9 and FZD10 [13].
  • PL-MSC grown in ESC medium showed an increased surface expression of SSEA-4 and frizzled-9 (FZD-9), an increased Oct-4 and nestin mRNA expression, and an induced expression of nanog-3 [11].

Analytical, diagnostic and therapeutic context of FZD9


  1. Expression profiles of 10 members of Frizzled gene family in human gastric cancer. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  2. Frizzled 9 knock-out mice have abnormal B-cell development. Ranheim, E.A., Kwan, H.C., Reya, T., Wang, Y.K., Weissman, I.L., Francke, U. Blood (2005) [Pubmed]
  3. Upregulation of frizzled 9 in astrocytomas. Zhang, Z., Schittenhelm, J., Guo, K., B??hring, H.J., Trautmann, K., Meyermann, R., Schluesener, H.J. Neuropathol. Appl. Neurobiol. (2006) [Pubmed]
  4. Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. Winn, R.A., Marek, L., Han, S.Y., Rodriguez, K., Rodriguez, N., Hammond, M., Van Scoyk, M., Acosta, H., Mirus, J., Barry, N., Bren-Mattison, Y., Van Raay, T.J., Nemenoff, R.A., Heasley, L.E. J. Biol. Chem. (2005) [Pubmed]
  5. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. Hashimoto, R., Suzuki, T., Iwata, N., Yamanouchi, Y., Kitajima, T., Kosuga, A., Tatsumi, M., Ozaki, N., Kamijima, K., Kunugi, H. Journal of neural transmission (Vienna, Austria : 1996) (2005) [Pubmed]
  6. A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. Wang, Y.K., Samos, C.H., Peoples, R., Pérez-Jurado, L.A., Nusse, R., Francke, U. Hum. Mol. Genet. (1997) [Pubmed]
  7. Antitumorigenic Effect of Wnt 7a and Fzd 9 in Non-small Cell Lung Cancer Cells Is Mediated through ERK-5-dependent Activation of Peroxisome Proliferator-activated Receptor {gamma}. Winn, R.A., Van Scoyk, M., Hammond, M., Rodriguez, K., Crossno, J.T., Heasley, L.E., Nemenoff, R.A. J. Biol. Chem. (2006) [Pubmed]
  8. Detection of an atypical 7q11.23 deletion in Williams syndrome patients which does not include the STX1A and FZD3 genes. Botta, A., Novelli, G., Mari, A., Novelli, A., Sabani, M., Korenberg, J., Osborne, L.R., Digilio, M.C., Giannotti, A., Dallapiccola, B. J. Med. Genet. (1999) [Pubmed]
  9. Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Kirikoshi, H., Sagara, N., Koike, J., Tanaka, K., Sekihara, H., Hirai, M., Katoh, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  10. Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. Jeong, S.H., Joo, E.J., Ahn, Y.M., Lee, K.Y., Kim, Y.S. Psychiatry research. (2006) [Pubmed]
  11. Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Battula, V.L., Bareiss, P.M., Treml, S., Conrad, S., Albert, I., Hojak, S., Abele, H., Schewe, B., Just, L., Skutella, T., Bühring, H.J. Differentiation (2007) [Pubmed]
  12. Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Wang, Y.K., Spörle, R., Paperna, T., Schughart, K., Francke, U. Genomics (1999) [Pubmed]
  13. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Benhaj, K., Akcali, K.C., Ozturk, M. Oncol. Rep. (2006) [Pubmed]
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