Disease relevance of FZD9

• Among 10 cases of primary gastric cancer, FZD9 was up-regulated in 2 cases, FZD2 and FZD8 were up-regulated in 4 cases [1].
• In humans, the FZD9 gene lies in the region of chromosome 7q11.23 deleted in the neurodevelopmental disorder, Williams-Beuren syndrome (WBS) [2].
• Furthermore, the FZD9 IR scores positively correlated with astrocytoma WHO grading (r = 1, P = 0.04) and proliferating activity (r = 0.77, P < 0.001) [3].
• Further FZD9 expression in native human brain tissue and glioblastoma cell line were analysed using real-time reverse transcription polymerase chain reaction (RT-PCR) [3].
• Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation [4].

Psychiatry related information on FZD9

• Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders [5].

High impact information on FZD9

• FZD3 is expressed predominantly in brain, testis, eye, skeletal muscle and kidney [6].
• By applying CpG island cloning methods to cosmids from the deletion region, we have identified a new gene, called FZD3 [6].
• Recent studies from our laboratory indicate that combined expression of the combination of Wnt 7a and Frizzled 9 (Fzd 9) in Non-small Cell Lung Cancer (NSCLC) cell lines inhibits transformed growth [7].
• The action of Wnt-7a correlated with expression of the specific Wnt receptor Frizzled-9 (Fzd-9), and transfection of Fzd-9 into a Wnt-7a-insensitive NSCLC cell line established Wnt-7a sensitivity [4].
• Detection of an atypical 7q11.23 deletion in Williams syndrome patients which does not include the STX1A and FZD3 genes [8].

Chemical compound and disease context of FZD9

• Real-time RT-PCR data showed that FZD9 expression in human glioblastoma was significant higher than in normal brain (P < 0.05) but FZD9 expression was only slightly induced in cobalt chloride-treated human glioblastoma T98G cells compared with untreated cells (P > 0.05) [3].

Biological context of FZD9

• FZD4 consists of two exons, while FZD9 and FZD10 consist of a single exon [9].
• Upregulation of frizzled 9 in astrocytomas [3].
• To replicate the previously reported positive association between FZD3 and schizophrenia in Han Chinese and Japanese populations, we genotyped two single nucleotide polymorphism (SNP) markers of FZD3 in 241 unrelated schizophrenic patients and 192 control subjects [10].

Anatomical context of FZD9

• Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation [11].
• In testis, Fzd9 is expressed in all spermatogenic cell types [12].

Other interactions of FZD9

• FZD9 and FZD10 were up-regulated together in TMK1 and MKN74 [1].
• HMEC expressed all Frizzled receptors except FZD9 and FZD10 [13].
• PL-MSC grown in ESC medium showed an increased surface expression of SSEA-4 and frizzled-9 (FZD-9), an increased Oct-4 and nestin mRNA expression, and an induced expression of nanog-3 [11].

Analytical, diagnostic and therapeutic context of FZD9

• In the present study, FZD9 expression in 25 astrocytomas was investigated using immunohistochemistry with specific antibodies [3].
• Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis [10].

References