Gene Review:
VSIG4 - V-set and immunoglobulin domain containing 4
Homo sapiens
Synonyms:
CRIg, Protein Z39Ig, UNQ317/PRO362, V-set and immunoglobulin domain-containing protein 4, Z39IG
- Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis. Lee, M.Y., Kim, W.J., Kang, Y.J., Jung, Y.M., Kang, Y.M., Suk, K., Park, J.E., Choi, E.M., Choi, B.K., Kwon, B.S., Lee, W.H. J. Leukoc. Biol. (2006)
- VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. Vogt, L., Schmitz, N., Kurrer, M.O., Bauer, M., Hinton, H.I., Behnke, S., Gatto, D., Sebbel, P., Beerli, R.R., Sonderegger, I., Kopf, M., Saudan, P., Bachmann, M.F. J. Clin. Invest. (2006)
- To be or not to be B7. Zang, X., Allison, J.P. J. Clin. Invest. (2006)
- Characterization of monoclonal antibody specific to the Z39Ig protein, a member of immunoglobulin superfamily. Kim, J.K., Choi, E.M., Shin, H.I., Kim, C.H., Hwang, S.H., Kim, S.M., Kwon, B.S. Immunol. Lett. (2005)
- Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X. Langnaese, K., Colleaux, L., Kloos, D.U., Fontes, M., Wieacker, P. Biochim. Biophys. Acta (2000)
- Z39Ig is co-expressed with activated macrophage genes. Walker, M.G. Biochim. Biophys. Acta (2002)