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Gene Review

VSIG4  -  V-set and immunoglobulin domain containing 4

Homo sapiens

Synonyms: CRIg, Protein Z39Ig, UNQ317/PRO362, V-set and immunoglobulin domain-containing protein 4, Z39IG
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Disease relevance of VSIG4


High impact information on VSIG4

  • The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues [2].
  • In this issue of the JCI, Vogt et al. show that the B7 family-related protein V-set and Ig domain-containing 4 (VSIG4) can act as an inhibitor of T cell activation (see the related article beginning on page 2817) [3].
  • Z39Ig staining was also observed in macrophages in the lining layers and sublining areas of rheumatoid arthritis synovium [1].
  • To identify the role(s) of Z39Ig in the function of macrophages, we used human monocytic cell lines TF-1A (Z39Ig-negative) and THP-1 (Z39Ig-positive) [1].
  • Z39Ig, a recently identified immunoglobulin (Ig) superfamily member, is localized in the pericentromeric region of human chromosome X and detectable in all human tissue, but it is predominantly expressed in fetal human tissues as well as in adult lungs and placenta [4].

Biological context of VSIG4


Anatomical context of VSIG4


  1. Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis. Lee, M.Y., Kim, W.J., Kang, Y.J., Jung, Y.M., Kang, Y.M., Suk, K., Park, J.E., Choi, E.M., Choi, B.K., Kwon, B.S., Lee, W.H. J. Leukoc. Biol. (2006) [Pubmed]
  2. VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. Vogt, L., Schmitz, N., Kurrer, M.O., Bauer, M., Hinton, H.I., Behnke, S., Gatto, D., Sebbel, P., Beerli, R.R., Sonderegger, I., Kopf, M., Saudan, P., Bachmann, M.F. J. Clin. Invest. (2006) [Pubmed]
  3. To be or not to be B7. Zang, X., Allison, J.P. J. Clin. Invest. (2006) [Pubmed]
  4. Characterization of monoclonal antibody specific to the Z39Ig protein, a member of immunoglobulin superfamily. Kim, J.K., Choi, E.M., Shin, H.I., Kim, C.H., Hwang, S.H., Kim, S.M., Kwon, B.S. Immunol. Lett. (2005) [Pubmed]
  5. Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X. Langnaese, K., Colleaux, L., Kloos, D.U., Fontes, M., Wieacker, P. Biochim. Biophys. Acta (2000) [Pubmed]
  6. Z39Ig is co-expressed with activated macrophage genes. Walker, M.G. Biochim. Biophys. Acta (2002) [Pubmed]
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