Disease relevance of Emb

• The aqueous infusion of the aerial parts of Zygophyllum gaetulum Emb. and Maire was tested orally (1 g/kg body weight) for hypoglycemic activity in alloxan-induced diabetic rats [1].

High impact information on Emb

• Embigin, a cell adhesion molecule important in cell/extracellular matrix (ECM) interactions, was also found in the UB and may serve as a Dolichos biflorus binding protein in the kidney [2].
• Comparisons of Emb coding sequences between species, including the full-length zebra fish, POU(c), are presented, together with a compilation of the multiple transcripts produced by alternative splicing and the presence of different transcriptional start and stop sites, from the Emb gene [3].
• Using Northern analysis, in situ hybridization analysis, RT-PCR, and Western analysis we have characterized the expression of embigin mRNA and protein in both regressing prostate and mammary gland [4].

Anatomical context of Emb

• We have identified embigin as a gene expressed during tissue regression in rat prostate and lactating mammary gland following hormonal ablation [4].

Analytical, diagnostic and therapeutic context of Emb

• The class VI POU domain family member known as Emb in the mouse (rat Brn5 or human mPOU/TCFbeta1) is present in vivo as a protein migrating at about 80 kDa on western blots, considerably larger than that predicted (about 42 kDa) from previously cloned coding sequences [3].

References