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Gene Review

Emb  -  embigin

Rattus norvegicus

Synonyms: Embigin, Gp70
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Disease relevance of Emb

  • The aqueous infusion of the aerial parts of Zygophyllum gaetulum Emb. and Maire was tested orally (1 g/kg body weight) for hypoglycemic activity in alloxan-induced diabetic rats [1].

High impact information on Emb


Anatomical context of Emb

  • We have identified embigin as a gene expressed during tissue regression in rat prostate and lactating mammary gland following hormonal ablation [4].

Analytical, diagnostic and therapeutic context of Emb

  • The class VI POU domain family member known as Emb in the mouse (rat Brn5 or human mPOU/TCFbeta1) is present in vivo as a protein migrating at about 80 kDa on western blots, considerably larger than that predicted (about 42 kDa) from previously cloned coding sequences [3].


  1. The hypoglycemic activity of Zygophyllum gaetulum extracts in alloxan-induced hyperglycemic rats. Jaouhari, J.T., Lazrek, H.B., Jana, M. Journal of ethnopharmacology. (2000) [Pubmed]
  2. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Stuart, R.O., Bush, K.T., Nigam, S.K. Kidney Int. (2003) [Pubmed]
  3. The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts. Relaix, F., Molinari, S., Lemonnier, M., Schäfer, B., Buckingham, M. Gene (2004) [Pubmed]
  4. Embigin, a developmentally expressed member of the immunoglobulin super family, is also expressed during regression of prostate and mammary gland. Guenette, R.S., Sridhar, S., Herley, M., Mooibroek, M., Wong, P., Tenniswood, M. Dev. Genet. (1997) [Pubmed]
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