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Disease relevance of Dolichos

  • The binding of the lectins from peanut, soy bean and Dolichos biflorus (specific for galactose and/or N-acetyl-D-galactosamine), to human breast carcinomas has been investigated [1].
  • Receptors for three lectins with restricted specificities, namely fucose-binding protein of Lotus tetragonolobus (FBP), peanut agglutinin (PNA) and Dolichos biflorus agglutinin (DBA), were distinctively located in 6- and 7-day mouse embryos and in embryoid bodies of teratocarcinoma OTT6050 grown in vivo [2].
  • For example, in order to monitor in vitro differentiation of multipotential embryonal carcinoma cells, stage-specific embryonic antigen-1 (SSEA-1) and the Lotus agglutinin receptor have been used as markers of the undifferentiated cells, and the Dolichos agglutinin receptor has been used as a marker of extraembryonic endoderm cells [3].
  • In squamous metaplasia induced by vitamin A deficiency, Dolichos biflorus agglutinin (DBA), wheat germ agglutinin (WGA), and peanut agglutinin (PNA) showed faint (+) to moderate (++) binding in both basal and suprabasal cells; Concanavalin A (Con A) showed moderate binding (++) to suprabasal cells and no binding in basal cells [4].
  • GDH and LDH activity in presence of hexaconazole was strongly affected in intact cells of some standard culture of bacteria like Rhizobium sp. (host Dolichos sp., 32.1 and 72.5%), Bacillus subtilis Cohn (86.75 and 76.5%), Azotobacter sp. (36.9 and 55.4%) and B. sphaericus (67.6% GDH) respectively [5].

High impact information on Dolichos

  • We report here the development of a mutation-induced marker in mice heterozygous at the Dlb-1 locus which determines the expression of binding sites for the lectin Dolichos biflorus agglutinin (DBA) in intestinal epithelium [6].
  • Competitive binding assays using 3H-labeled blood group A substance and insolubilized Dolichos biflorus lectin or human anti-A were carried out, measuring competition by blood group A1 and A2 glycoproteins, and by unabsorbed anti-A sera, and with these sera absorbed with the A1 and A2 glycoproteins [7].
  • In the adult proximal colon only the goblet cell mucin in the upper portion of the crypts was specifically labeled by the lectin Dolichos biflorus agglutinin (DBA), whereas this gradient was progressively lost distally; mucin in the upper and lower crypts of the sigmoid colon and rectum bound the label uniformly [8].
  • cDNA cloning of FRIL, a lectin from Dolichos lablab, that preserves hematopoietic progenitors in suspension culture [9].
  • By the fourth passage after treatment, both carcinogens induced increased survival, colony formation in agar-methocel, multinucleation, and increased reactivity with the tumor associated antigen B1:1, an epitope of carcinoembryonic antigen, and the lectins concanavalin A, Dolichos biflorus, and soybean agglutinin [10].

Biological context of Dolichos


Anatomical context of Dolichos

  • The immunophenotype of ductular structures was assessed by the expression of two bile duct epithelium determinants, wide spectrum cytokeratin and epithelial membrane antigen (EMA), and by their glycoconjugate expression using the specific binding lectins Dolichos biflorus agglutinin (DBA) and soybean agglutinin (SBA) [16].
  • RESULTS: Among goblet cells from colonic mucosa samples of individuals without colonic neoplasia, there was a high mean deoxycholate-induced apoptotic index (AI) of 59.1% and high Dolichos biflorus agglutinin (DBA) lectin reactivity (differentiation) in 85.0% of samples [17].
  • The presence of these yolk sac endoderm layers was confirmed by light microscopy and analysis of biochemical markers including alpha-fetoprotein, type IV collagen, laminin, and binding sites for Dolichos biflorus agglutinin [18].
  • Therefore the pulmonary capillaries of 18 Large White pigs aged less than 10 minutes, 1 week, and 6 months (six animals at each age) were perfused with cationized ferritin and the peroxidase conjugated lectins Dolichos bifloris, concanavalin A, Triticum vulgaris, and Ricinus communis type 2 [19].
  • B lymphocyte specificity of lectins of Cepaea nemoralis and Dolichos biflorus: paradoxical binding of anti-A active lectins to human lymphocyte subclasses [20].

Associations of Dolichos with chemical compounds


Gene context of Dolichos

  • Histochemical analysis 14 days after transplantation showed that some ducts were positive for Pax-2, endo A cytokeratin, kidney-specific cadherin, and Dolichos biflorus agglutinin and that dichotomous branching of these ducts had occurred [25].
  • This assay entailed coating microtiter plate wells with dolichos biflorus agglutinin and detecting the bound mucin that was secreted into a buffer solution by the tracheal segments [26].
  • The dysplastic tubules are of distal nephron origin [Dolichos biflorus agglutinin (DBA)- and aquaporin-2 (AQP2) positive, and angiotensinogen negative] [27].
  • This antibody recognizes a 116-kDa glycoprotein, which we have termed CST1, containing sugar residues that bind Dolichos biflorans lectin (DBA) [28].
  • Cells from junctional tissue and gingival tissue were compared immunocytochemically using monoclonal antibodies to keratin, vimentin, and desmoplakins I and II and using Dolichos biflorus agglutinin (DBA) [29].

Analytical, diagnostic and therapeutic context of Dolichos


  1. The binding of peroxidase-labelled lectins to human breast epithelium. IV--The reactivity of breast carcinomas to peanut, soy bean and Dolichos biflorus agglutinins. Walker, R.A. J. Pathol. (1985) [Pubmed]
  2. Differential expression of lectin receptors in germ layers of the mouse egg cylinder and teratocarcinomas. Hamada, H., Sato, M., Murata, F., Muramatsu, T. Exp. Cell Res. (1983) [Pubmed]
  3. Developmentally regulated expression of cell surface carbohydrates during mouse embryogenesis. Muramatsu, T. J. Cell. Biochem. (1988) [Pubmed]
  4. Differences in lectin binding in squamous metaplasia induced by benzo(a)pyrene and vitamin A deficiency in hamster tracheal explants. Chopra, D.P., Joiakim, A.P. In Vitro Cell. Dev. Biol. (1991) [Pubmed]
  5. Influence of hexaconazole, carbofuran and ethion on soil microflora and dehydrogenase activities in soil and intact cell. Kalam, A., Mukherjee, A.K. Indian J. Exp. Biol. (2001) [Pubmed]
  6. A clonal marker induced by mutation in mouse intestinal epithelium. Winton, D.J., Blount, M.A., Ponder, B.A. Nature (1988) [Pubmed]
  7. Immunochemical studies on blood groups LXVI. Competitive binding assays of A1 and A2 blood group substances with insolubilized anti-A serum and insolubilized A agglutinin from Dolichos biflorus. Kisailus, E.C., Kabat, E.A. J. Exp. Med. (1978) [Pubmed]
  8. Regional differences in normal and cancer-associated glycoconjugates of the human colon. Bresalier, R.S., Boland, C.R., Kim, Y.S. J. Natl. Cancer Inst. (1985) [Pubmed]
  9. cDNA cloning of FRIL, a lectin from Dolichos lablab, that preserves hematopoietic progenitors in suspension culture. Colucci, G., Moore, J.G., Feldman, M., Chrispeels, M.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. Expression of phenotypical changes by human breast epithelial cells treated with carcinogens in vitro. Russo, J., Reina, D., Frederick, J., Russo, I.H. Cancer Res. (1988) [Pubmed]
  11. The complete primary structure of a unique mannose/glucose-specific lectin from field bean (Dolichos lab lab). Gowda, L.R., Savithri, H.S., Rao, D.R. J. Biol. Chem. (1994) [Pubmed]
  12. Effect of plant lectins on Ustilago maydis in vitro. Santiago, A.P., Saavedra, E., Pérez Campos, E., Córdoba, F. Cell. Mol. Life Sci. (2000) [Pubmed]
  13. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Stuart, R.O., Bush, K.T., Nigam, S.K. Kidney Int. (2003) [Pubmed]
  14. Effect of epsilon-amino caproic acid of floral morphogenesis in Dolichos lab-lab. Rajendra, B.R., Mujeeb, K.A., Bates, L.S. Chem. Biol. Interact. (1979) [Pubmed]
  15. Fetal ontogeny and role of metanephric bradykinin B2 receptors. El-Dahr, S.S., Dipp, S., Meleg-Smith, S., Pinna-Parpaglia, P., Madeddu, P. Pediatr. Nephrol. (2000) [Pubmed]
  16. Ductular structures in acute hepatitis with panacinar necrosis. Delladetsima, J.K., Kyriakou, V., Vafiadis, I., Karakitsos, P., Smyrnoff, T., Tassopoulos, N.C. J. Pathol. (1995) [Pubmed]
  17. Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients. Bernstein, H., Holubec, H., Warneke, J.A., Garewal, H., Earnest, D.L., Payne, C.M., Roe, D.J., Cui, H., Jacobson, E.L., Bernstein, C. Ann. Surg. Oncol. (2002) [Pubmed]
  18. Induction of yolk sac endoderm in GATA-4-deficient embryoid bodies by retinoic acid. Bielinska, M., Wilson, D.B. Mech. Dev. (1997) [Pubmed]
  19. Greater permeability of the neonatal lung. Postnatal changes in surface charge and biochemistry of porcine pulmonary capillary endothelium. Mills, A.N., Haworth, S.G. J. Thorac. Cardiovasc. Surg. (1991) [Pubmed]
  20. B lymphocyte specificity of lectins of Cepaea nemoralis and Dolichos biflorus: paradoxical binding of anti-A active lectins to human lymphocyte subclasses. Zalewski, P.D., Forbes, I.J., Uhlenbruck, G., Valente, L. Clin. Exp. Immunol. (1981) [Pubmed]
  21. Selective binding of Dolichos biflorus agglutinin to L3T4-, Lyt-2- thymocytes. Expression of terminal alpha-linked N-acetyl-D-galactosamine residues defines a subpopulation of fetal and adult murine thymocytes. Farr, A.G., Anderson, S.K., Braddy, S.C., Mejino, J.L. J. Immunol. (1988) [Pubmed]
  22. Adenine binding sites of the lectin from lima beans (Phaseolus lunatus). Roberts, D.D., Goldstein, I.J. J. Biol. Chem. (1983) [Pubmed]
  23. Photoaffinity labeling of the adenine binding sites of two Dolichos biflorus lectins. Gegg, C.V., Etzler, M.E. J. Biol. Chem. (1994) [Pubmed]
  24. Isolation and characterization of cyanogen bromide fragments and a glycopeptide from the Dolichos biflorus lectin. Carter, W.G., Etzler, M.E. Biochemistry (1975) [Pubmed]
  25. Branching ducts similar to mesonephric ducts or ureteric buds in teratomas originating from mouse embryonic stem cells. Yamamoto, M., Cui, L., Johkura, K., Asanuma, K., Okouchi, Y., Ogiwara, N., Sasaki, K. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  26. Regulation of mucin secretion in the ferret trachea. Kishioka, C., Cheng, P.W., Seftor, R.E., Lartey, P.A., Rubin, B.K. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1997) [Pubmed]
  27. Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions in kidney development. El-Dahr, S.S., Harrison-Bernard, L.M., Dipp, S., Yosipiv, I.V., Meleg-Smith, S. Physiol. Genomics (2000) [Pubmed]
  28. Initial characterization of CST1, a Toxoplasma gondii cyst wall glycoprotein. Zhang, Y.W., Halonen, S.K., Ma, Y.F., Wittner, M., Weiss, L.M. Infect. Immun. (2001) [Pubmed]
  29. Culture and characterization of human junctional epithelial cells. Matsuyama, T., Izumi, Y., Sueda, T. J. Periodontol. (1997) [Pubmed]
  30. Purification and characterization of Dolichos lablab lectin. Mo, H., Meah, Y., Moore, J.G., Goldstein, I.J. Glycobiology (1999) [Pubmed]
  31. Dolichos biflorus agglutinin (DBA) reveals a similar basal cell differentiation in normal and psoriatic epidermis. Kariniemi, A.L., Virtanen, I. Histochemistry (1989) [Pubmed]
  32. Crystallization and preliminary X-ray crystallographic analysis of a galactose-specific lectin from Dolichos lablab. Latha, V.L., Kulkarni, K.A., Rao, R.N., Kumar, N.S., Suguna, K. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  33. The preputial gland of the Japanese serow Capricornis crispus: ultrastructure and lectin histochemistry. Atoji, Y., Suzuki, Y., Sugimura, M. Acta anatomica. (1989) [Pubmed]
  34. Monoclonal antibodies against the Tn-specific isolectin B4 from Vicia villosa seeds: characterization of the epitope of the blocking antibody VV34. Medeiros, A., Berois, N., Balter, H., Robles, A., Perez-Payá, E., Gimenez, A., Calvete, J.J., Osinaga, E. Hybrid. Hybridomics (2004) [Pubmed]
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