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Chemical Compound Review

SureCN2833211     1-amino-4-hydroxy-2-(6...

Synonyms: AC1Q6JTM, AR-1C1492, AC1L3NA8, AC1Q5190, A844942, ...
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Disease relevance of Substance


Psychiatry related information on Substance

  • BACKGROUND: Public Law 102-321 established a block grant for adults with "serious mental illness" (SMI) and required the Substance Abuse and Mental Health Services Administration (SAMHSA) to develop a method to estimate the prevalence of SMI [6].
  • A special Substance Abuse Module covers tobacco, alcohol, and other drug abuse in considerable detail, allowing the assessment of the quality and severity of dependence and its course [7].
  • RESULTS: Substance use disorder plus PTSD was experienced by a significant minority of the Australian general population (0.5%) [8].
  • We used multivariate structural equation modeling to identify common genetic risk factors for major depression, generalized anxiety disorder, panic disorder, agoraphobia, social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders [9].
  • CONCLUSIONS: Substance abuse is associated with low levels of satisfaction with family relationships among persons with severe mental illness [10].

High impact information on Substance

  • BACKGROUND & AIMS: Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system [11].
  • OBJECTIVE: To evaluate the efficacy of a new behavioral treatment for drug abuse in this population: Behavioral Treatment for Substance Abuse in Severe and Persistent Mental Illness (BTSAS) [12].
  • CONCLUSIONS: (1) Substance P- and acetylcholine-induced coronary vasodilation, like that to acetylcholine, is at least partly due to stimulation of NO activity, indicating that the dysfunction of the coronary vascular endothelial cell layer is not restricted to muscarinic receptors [13].
  • Four major observations were made: (1) Substance P- and cholecystokinin-like immunoreactivity coexist in populations of varicosities in sensory and autonomic regions of rat spinal segment L6 [14].
  • Here we report that alternative, nonapoptotic pcd induced by the neurokinin-1 receptor (NK(1)R) activated by its ligand Substance P, is mediated by a MAPK phosphorylation cascade recruited by the scaffold protein arrestin 2 [15].

Chemical compound and disease context of Substance


Biological context of Substance


Anatomical context of Substance


Associations of Substance with other chemical compounds


Gene context of Substance

  • RESULTS: Substance P caused dose-dependent increases in blood flow (P < 0.001) and plasma t-PA antigen (P = 0.04) and activity (P < 0.001) concentrations confined to the infused forearm, but had no effect on plasminogen activator inhibitor type I (PAI-I) or von Willebrand factor concentrations [33].
  • The human NK-1 receptor transfected in Chinese hamster ovary (CHO) cells was studied with use of different tachykinin analogs: Substance P, [Pro9]SP, [Sar9, Met(O2)11]SP, [Gly9 psi (CH2CH2) Leu10]SP, Ac-Arg-septide, septide, [Gly9 psi (CH2CH2) Gly10]SP, NKA, [pGlu6]SP(6-11) and [Lys5]NKA(4-10) [34].
  • Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells [35].
  • RESULTS: Substance P induced IL-8 secretion from cultured pulp cells (approximately threefold increase over control, P < 0.05) and from pulp tissue explants (two- to three fold) [36].
  • Biliary water and electrolytes are augmented by gastrin, CCK-PZ, secretin and VIP and inhibited by Substance P [37].

Analytical, diagnostic and therapeutic context of Substance

  • PARTICIPANTS: More than 5000 members of male-male and female-female twin pairs from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders [38].
  • METHOD: Substance-abusing patients (N=285) from substance abuse/dual-diagnosis treatment settings and mental health treatment settings participated in test and blind retest interviews with the PRISM-IV, which includes specific guidelines for assessment of substance abusers [39].
  • Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase-resistant analog of Substance P [40].
  • 2. Substance P caused an endothelium-dependent increase in lymphatic constriction frequency which was first significant at a concentration of 1 nM (115 +/- 3% of control, n = 11) with 1 microM, the highest concentration tested, increasing the rate to 153 +/- 4% of control (n = 9) [41].
  • RESULTS: Substance P concentrations in nasal lavages increased in a dose-dependent fashion during nasal bradykinin challenge in both groups [42].


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  15. Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. Castro-Obregón, S., Rao, R.V., del Rio, G., Chen, S.F., Poksay, K.S., Rabizadeh, S., Vesce, S., Zhang, X.K., Swanson, R.A., Bredesen, D.E. J. Biol. Chem. (2004) [Pubmed]
  16. Sensitive gas chromatography-mass spectrometry method for simultaneous measurement of MDEA, MDMA, and metabolites HMA, MDA, and HMMA in human urine. Pirnay, S.O., Abraham, T.T., Huestis, M.A. Clin. Chem. (2006) [Pubmed]
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  26. Platelet dense granule secretion in adolescents with conduct disorder and substance abuse: preliminary evidence for variation in signal transduction. Moss, H.B., Yao, J.K. Biol. Psychiatry (1996) [Pubmed]
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  33. The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man. Newby, D.E., Wright, R.A., Dawson, P., Ludlam, C.A., Boon, N.A., Fox, K.A., Webb, D.J. Cardiovasc. Res. (1998) [Pubmed]
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  40. Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase-resistant analog of Substance P. Martin, J.L., Sloviter, R.S. J. Comp. Neurol. (2001) [Pubmed]
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