Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Scgb3a2 - secretoglobin, family 3A, member 2

Mus musculus

Synonyms: LuLeu1, PnSP-1, Pneumo secretory protein 1, Pnsp1, Secretoglobin family 3A member 2, ...

Chiba, Y. et al., Chiba, Y. et al., Wang, Y. et al., Chiba, Y. et al., Heinzmann, A. et al.

Heinzmann, Dietrich, Deichmann,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Scgb3a2

In the present study, a relationship between airway inflammation, UGRP1 expression, and interleukin-9 (IL-9), an asthma candidate gene, was evaluated by using a murine model of allergic bronchial asthma [1].
Objectives: The aim of study was to understand the effect of overexpressed UGRP1 on lung inflammation in a mouse model of allergic airway inflammation [2].
Methods: Ovalbumin-sensitized and -challenged mice, a model for allergic airway inflammation, were used in conjunction with recombinant adenovirus expressing UGRP1 [2].

High impact information on Scgb3a2

To address this issue we have characterized the phenotype of UGRP knock-out mice [3].
However, in contrast to G6Pase(-/-) mice and patients with GSD type 1a, UGRP(-/-) mice exhibit no change in hepatic glycogen content, blood glucose, or triglyceride levels [3].
As such, the phenotype of UGRP(-/-) mice is mild, indicating that G6Pase is the major glucose-6-phosphatase of physiological importance for glucose homeostasis in vivo [3].
Rationale: Uteroglobin-related protein (UGRP) 1, which is highly expressed in the epithelial cells of the airways, has been suggested to play a role in lung inflammation [2].
A significant inverse correlation between lung Ugrp1 mRNA levels and IL-9 levels in BAL fluid was demonstrated by regression analysis (r = 0.616, P = 0.023) [1].

Biological context of Scgb3a2

Together, these results indicate an involvement of IL-5 in the down-regulation of Ugrp1 expression in airway inflammation such as allergic asthma disease [4].

Anatomical context of Scgb3a2

Uteroglobin-related protein 1 (UGRP1) is a secretory protein, highly expressed in epithelial cells of airways [1].
The encoded protein - uteroglobin-related protein 1 (UGRP1) - is thought to act as an anti-inflammatory agent and is mainly expressed in the lung and trachea [5].

Analytical, diagnostic and therapeutic context of Scgb3a2

In this animal model of airway inflammation, lung Ugrp1 mRNA expression was greatly decreased compared with control mice [1].
Intranasal administration of IL-9 to naive mice decreased the level of Ugrp1 expression in lungs [1].
Interestingly, these "OVA-challenged" mice show down-regulation of Ugrp1 expression as compared with the control group [4].

References

Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9. Chiba, Y., Kusakabe, T., Kimura, S. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
Uteroglobin-related Protein 1 Expression Suppresses Allergic Airway Inflammation in Mice. Chiba, Y., Kurotani, R., Kusakabe, T., Miura, T., Link, B.W., Misawa, M., Kimura, S. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
Deletion of the Gene Encoding the Ubiquitously Expressed Glucose-6-phosphatase Catalytic Subunit-related Protein (UGRP)/Glucose-6-phosphatase Catalytic Subunit-beta Results in Lowered Plasma Cholesterol and Elevated Glucagon. Wang, Y., Oeser, J.K., Yang, C., Sarkar, S., Hackl, S.I., Hasty, A.H., McGuinness, O.P., Paradee, W., Hutton, J.C., Powell, D.R., O'brien, R.M. J. Biol. Chem. (2006) [Pubmed]
Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. Chiba, Y., Srisodsai, A., Supavilai, P., Kimura, S. Immunol. Lett. (2005) [Pubmed]
Association of uteroglobulin-related protein 1 with bronchial asthma. Heinzmann, A., Dietrich, H., Deichmann, K.A. Int. Arch. Allergy Immunol. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SCGB3A2	Canis lupus familiaris
SCGB3A2	Homo sapiens
SCGB3A2	Macaca mulatta
SCGB3A2	Pan troglodytes
Scgb3a2	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.