The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SCGB3A2  -  secretoglobin, family 3A, member 2

Homo sapiens

Synonyms: LU103, PNSP1, PnSP-1, Pneumo secretory protein 1, Secretoglobin family 3A member 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SCGB3A2


High impact information on SCGB3A2

  • UGRP1 is a homodimeric secretory protein of 17 kDa and is expressed only in lung and trachea [6].
  • In the present article, we describe UGRP1 (encoding uteroglobin-related protein 1) as one of asthma-susceptibility genes that is located on chromosome 5q31-q32 [6].
  • This IL-10 induction of Ugrp1 gene expression occurs at the transcriptional level when examined using mouse embryonic lung primary cultures [7].
  • Our findings suggest that UGRP1-MARCO is a ligand-receptor pair that is probably involved in inflammation and pathogen clearance in the lung [2].
  • In a mammalian expression system, secreted recombinant UGRP1 was copurified with apolipoprotein A-I [2].

Biological context of SCGB3A2


Anatomical context of SCGB3A2

  • UGRP1 mRNA is predominantly expressed in the lung, with low levels of expression in the thyroid [8].
  • Changes in sputum UGRP1 in atopic asthma were not linked to permeability changes reflected by increased albumin levels but correlated positively with sputum macrophages and negatively with eosinophils [3].
  • The overall rate of penicillin-nonsusceptible pneumococcal (PNSP) strains was 11%; specific prevalence rates, according to the sources of the isolates, were as follows: blood, 6%; cerebrospinal fluid, 10%; lower respiratory tract, 10%; and middle ear, 18% [11].
  • In contrast to the G6Pase catalytic subunit gene promoter, the UGRP promoter was highly active in all cell lines examined [10].
  • Among PNSP only 2 strains were isolated from sterile body fluids, one having MIC >3.84 mg/l. Lack of susceptibility to cotrimoxazole was 38.4% [12].

Associations of SCGB3A2 with chemical compounds

  • Twelve PNSP were resistant to other drugs: chloramphenicol (5), tetracycline (6), trimethoprim-sulfamethoxazole (5), cefotaxime (1), and erythromycin (1) [5].
  • The aims of this study were to evaluate the resistance patterns and serotypes/groups of penicillin non-susceptible pneumococci (PNSP) in Finland, and to determine phenotypes and resistance mechanisms of the erythromycin-resistant isolates [13].
  • The was a significant correlation between antibiotic use and the proportion of PNSP (correlation coefficient, 0.96; P = 0.002), and the correlation coefficients for trimethoprim-sulfamethoxazole, amoxicillins, macrolides and cephalosporins were significant at the 0.001 level [14].
  • There was no significant correlation between the use of penicillin V and the frequency of PNSP [14].
  • Most of the penicillin-nonsusceptible S. pneumoniae (PNSP) were also nonsusceptible to other antibiotics except cefotaxime, and imipenem [15].

Other interactions of SCGB3A2

  • SCGB3A1 messenger RNA localizes to a subset of SCGB3A2-expressing cells within bronchi of both mouse and neonatal human lungs [1].
  • By contrast, sputum CC16 did not change significantly in either condition, although it was positively correlated with UGRP1 in patients and control subjects [3].
  • Using a retroviral vector-mediated expression cloning approach, we identified macrophage scavenger receptor with collagenous structure (MARCO) as a receptor for UGRP1 [2].
  • The novel proteins identified, considered to be involved in host defence, are cystatin A, UGRP-1, and calgranulin A, B and C. These proteins add protective functions to vernix such as antifungal activity, opsonizing capacity, protease inhibition and parasite inactivation [16].

Analytical, diagnostic and therapeutic context of SCGB3A2

  • In vivo experiments using mouse embryonic lung organ culture and intranasal administration of interleukin (IL) 10 revealed that constitutive expression of Ugrp1 mRNA is enhanced by IL-10 [7].
  • 5. In T/ebp/Nkx2.1-null embryo lungs, UGRP1 expression was significantly reduced as assessed by RT-PCR analysis [8].
  • Northern blot analysis demonstrated that UGRP1 is specifically expressed by lung, but not by the other tissues examined [2].
  • PFGE typing and serotyping suggest that the frequency of PNSP in the San Antonio, Texas, area is not due to dissemination of a single clonal strain [5].
  • Niimi et al. showed the -112G/A polymorphism of the UGRP1 gene to be associated with asthma in a case-control study [17].


  1. Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. Reynolds, S.D., Reynolds, P.R., Pryhuber, G.S., Finder, J.D., Stripp, B.R. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  2. Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. Bin, L.H., Nielson, L.D., Liu, X., Mason, R.J., Shu, H.B. J. Immunol. (2003) [Pubmed]
  3. Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis. de Burbure, C., Pignatti, P., Corradi, M., Malerba, M., Clippe, A., Dumont, X., Moscato, G., Mutti, A., Bernard, A. Chest (2007) [Pubmed]
  4. Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes. Albrich, W.C., Monnet, D.L., Harbarth, S. Emerging Infect. Dis. (2004) [Pubmed]
  5. The clinical and molecular epidemiology of bacteremias at a university hospital caused by pneumococci not susceptible to penicillin. Moreno, F., Crisp, C., Jorgensen, J.H., Patterson, J.E. J. Infect. Dis. (1995) [Pubmed]
  6. A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. Niimi, T., Munakata, M., Keck-Waggoner, C.L., Popescu, N.C., Levitt, R.C., Hisada, M., Kimura, S. Am. J. Hum. Genet. (2002) [Pubmed]
  7. Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. Srisodsai, A., Kurotani, R., Chiba, Y., Sheikh, F., Young, H.A., Donnelly, R.P., Kimura, S. J. Biol. Chem. (2004) [Pubmed]
  8. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. Niimi, T., Keck-Waggoner, C.L., Popescu, N.C., Zhou, Y., Levitt, R.C., Kimura, S. Mol. Endocrinol. (2001) [Pubmed]
  9. Nationwide surveillance of nasopharyngeal Streptococcus pneumoniae isolates from children with respiratory infection, Switzerland, 1998-1999. Mühlemann, K., Matter, H.C., Täuber, M.G., Bodmer, T. J. Infect. Dis. (2003) [Pubmed]
  10. Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. Martin, C.C., Oeser, J.K., Svitek, C.A., Hunter, S.I., Hutton, J.C., O'Brien, R.M. J. Mol. Endocrinol. (2002) [Pubmed]
  11. Epidemiological features of and risk factors for infection by Streptococcus pneumoniae strains with diminished susceptibility to penicillin: findings of a French survey. Bédos, J.P., Chevret, S., Chastang, C., Geslin, P., Régnier, B. Clin. Infect. Dis. (1996) [Pubmed]
  12. Drawbacks of antibiotic susceptibility of Streptococcus pneumoniae. Pasticci, M.B., Baldelli, F., Cardaccia, A., Moretti, A., Papili, R., Stagni, G. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive. (2003) [Pubmed]
  13. Rapid increase in macrolide resistance among penicillin non-susceptible pneumococci in Finland, 1996-2000. Pihlajamäki, M., Kaijalainen, T., Huovinen, P., Jalava, J. J. Antimicrob. Chemother. (2002) [Pubmed]
  14. Frequency of penicillin-resistant pneumococci in children is correlated to community utilization of antibiotics. Melander, E., Ekdahl, K., Jönsson, G., Mölstad, S. Pediatr. Infect. Dis. J. (2000) [Pubmed]
  15. Evaluation of susceptibility status of invasive pneumococcal isolates to various antibiotics and risk factors associated with invasive penicillin-nonsusceptible pneumococcal infection: Bangkok 1997-1998. Chokephaibulkit, K., Srifuengfung, S., Mingbanjerdsuk, J., Tosasuk, K., Vanprapar, N., Chearskul, S., Dhiraputra, C. Southeast Asian J. Trop. Med. Public Health (2000) [Pubmed]
  16. Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions. Tollin, M., Bergsson, G., Kai-Larsen, Y., Lengqvist, J., Sjövall, J., Griffiths, W., Skúladóttir, G.V., Haraldsson, A., Jörnvall, H., Gudmundsson, G.H., Agerberth, B. Cell. Mol. Life Sci. (2005) [Pubmed]
  17. No evidence for association between the -112G/A polymorphism of UGRP1 and childhood atopic asthma. Jian, Z., Nakayama, J., Noguchi, E., Shibasaki, M., Arinami, T. Clin. Exp. Allergy (2003) [Pubmed]
WikiGenes - Universities