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Gene Review

aac(6')-Ib  -  acetyltransferase

Klebsiella pneumoniae

 
 
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Disease relevance of aac(6')-Ib

 

High impact information on aac(6')-Ib

  • The second gene cassette was the result of a fusion event between bla(OXA-10)-type and aac(6')-Ib gene cassettes and conferred resistance to kanamycin [3].
  • The gene aac(6')-Ib is included in a gene cassette, and both aadA1 and bla(OXA-9) are included in a single-gene cassette that may have arisen as a consequence of a recombination event involving two integrons [4].
  • A circular sequence of 11,354 bp was generated, of which 7,993 bp make up Tn1331, a transposon including the antibiotic resistance genes aac(6')-Ib, aadA1, bla(OXA-9), and bla(TEM-1) [4].
  • The MICs of amikacin and isepamicin, their bactericidal effects, and AAC(6')-Ib production appeared to be well correlated among the clinical isolates and the transconjugants [2].
  • The effect of production of the aminoglycoside 6'-N-acetyltransferase [AAC(6')-IB] in Klebsiella pneumoniae on the outcome of amikacin and isepamicin treatment of rabbits with experimental endocarditis was assessed [2].
 

Biological context of aac(6')-Ib

References

  1. Characterization of the aac(6')-Ib gene encoding an aminoglycoside 6'-N-acetyltransferase in Pseudomonas aeruginosa BM2656. Galimand, M., Lambert, T., Gerbaud, G., Courvalin, P. Antimicrob. Agents Chemother. (1993) [Pubmed]
  2. Resistance to amikacin and isepamicin in rabbits with experimental endocarditis of an aac(6')-Ib-bearing strain of Klebsiella pneumoniae susceptible in vitro. Caulin, E., Coutrot, A., Carbon, C., Collatz, E. Antimicrob. Agents Chemother. (1996) [Pubmed]
  3. Molecular characterization of a new class 3 integron in Klebsiella pneumoniae. Correia, M., Boavida, F., Grosso, F., Salgado, M.J., Lito, L.M., Cristino, J.M., Mendo, S., Duarte, A. Antimicrob. Agents Chemother. (2003) [Pubmed]
  4. Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1. Sarno, R., McGillivary, G., Sherratt, D.J., Actis, L.A., Tolmasky, M.E. Antimicrob. Agents Chemother. (2002) [Pubmed]
  5. Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331. Tolmasky, M.E., Crosa, J.H. Plasmid (1993) [Pubmed]
  6. IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain. Giakkoupi, P., Tzouvelekis, L.S., Tsakris, A., Loukova, V., Sofianou, D., Tzelepi, E. Antimicrob. Agents Chemother. (2000) [Pubmed]
  7. Characterization of mutants of the 6'-N-acetyltransferase encoded by the multiresistance transposon Tn1331: effect of Phen171-to-Leu171 and Tyr80-to-Cys80 substitutions. Panaite, D.M., Tolmasky, M.E. Plasmid (1998) [Pubmed]
 
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