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Gene Review

CPO  -  carboxypeptidase O

Homo sapiens

Synonyms: Carboxypeptidase O
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Disease relevance of CPO

  • Population genetic and embryologic studies suggest that cleft palate only (CPO) may be a distinct clinical entity from cleft lip with or without cleft palate (CL/P) [1].
  • Mutational screening was performed in infants with nonsyndromic CPO or CL/P who were identified by the Iowa Birth Defects Registry [1].
  • BACKGROUND:: Nonsyndromic cleft lip with or without cleft palate (CL/P) or cleft palate only (CPO) are orofacial clefts and have a multifactorial etiology [2].

High impact information on CPO

  • The CP on chromosome 2 is predicted to cleave substrates with C-terminal acidic residues and was named CPO [3].
  • 9t,11t-conjugated linoleic acid was detected in the liver tissue and colonic mucosa of rats fed the CPO-containing diet [4].
  • Also, the effect of CPO on the fatty acid composition of liver tissue and colonic mucosa, the serum levels of total cholesterol and triglyceride, and the mRNA expression of cyclooxygenase (COX)-2 in the colonic mucosa were measured [4].
  • In the present study, we investigated whether dietary administration with CPO affects the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in male F344 rats to elucidate its possible cancer chemopreventive efficiency [4].
  • The indices of cell proliferation and apoptosis in the colonic mucosa of rats treated with AOM and 1% CPO have significant differences when compared with the AOM alone group [4].

Biological context of CPO


Associations of CPO with chemical compounds

  • Additionally, dietary administration with CPO decreased the serum triglyceride level and the expression of COX-2 mRNA in the colonic mucosa [4].
  • Catalpa (Catalpa ovata) seed oil (CPO) is a unique oil that contains a high amount of 9trans,11trans,13cis-conjugated linolenic acid [4].
  • Being a boy (OR, 2.0; 95% CI, 1.4-3.0), folic acid supplementation (OR, 0.6; 95% CI, 0.4-0.9), and low paternal education (OR, 1.6; 95% CI, 1.0-2.3) mainly determined CL/P in the multivariate analyses, compared to low paternal (OR, 4.5; 95% CI, 2.1-9.4) and maternal medication use (OR, 2.0; 95% CI, 1.0-4.0) for CPO [2].


  1. Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts. Barrow, L.L., Wines, M.E., Romitti, P.A., Holdener, B.C., Murray, J.C. Teratology (2002) [Pubmed]
  2. Periconceptional health and lifestyle factors of both parents affect the risk of live-born children with orofacial clefts. Krapels, I.P., Zielhuis, G.A., Vroom, F., de Jong-van den Berg, L.T., Kuijpers-Jagtman, A.M., van der Molen, A.B., Steegers-Theunissen, R.P. Birth Defects Res. Part A Clin. Mol. Teratol. (2006) [Pubmed]
  3. Identification and characterization of three members of the human metallocarboxypeptidase gene family. Wei, S., Segura, S., Vendrell, J., Aviles, F.X., Lanoue, E., Day, R., Feng, Y., Fricker, L.D. J. Biol. Chem. (2002) [Pubmed]
  4. Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats. Suzuki, R., Yasui, Y., Kohno, H., Miyamoto, S., Hosokawa, M., Miyashita, K., Tanaka, T. Oncol. Rep. (2006) [Pubmed]
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