Disease relevance of CRG

• The CDC HIV/AIDS Prevention Research Synthesis (PRS) project is working closely with the CRG on HIV/AIDS to produce Cochrane reviews of behavioral prevention interventions and on development and maintenance of a centralized, cumulative electronic database of HIV/AIDS behavioral prevention studies [1].
• CHARGE association with choanal atresia and inner ear hypoplasia in a child with a de novo chromosome translocation t(2;7)(p14;q21.11) [2].
• CHARGE association is a non-random occurrence of congenital malformations including coloboma, heart disease, choanal atresia, retarded growth and/or retarded development, genital hypoplasia, ear anomalies and/or deafness [3].
• Charge association vs. velo-cardio-facial syndrome [4].
• CHARGE association includes patients with at least four features prefixed by the letters of the mnemonic: Coloboma, Heart defects, Atresia of the choanae, Retarded growth and development, Genital hypoplasia, Ear anomalies and/or hearing loss [5].

High impact information on CRG

• CHARGE association, hemifacial microsomia, and Shprintzen syndrome [6].
• Infective Endocarditis in an Adult Patient With CHARGE Association: A Case Report [7].
• CHARGE association (CA) consists of a non-random association of ocular coloboma (C), heart anomaly (H), atresia of choanae (A), retarded growth and/or development (R), genital hypoplasia (G), and ear anomalies and/or hearing impairment (E) [8].
• CHARGE association is the sporadic, non-random concurrence of Coloboma of the eye, Heart anomalies, choanal Atresia, Retardation of growth and development, Genitourinary anomalies, Ear anomalies and deafness (CHARGE association) [9].
• CHARGE association and secondary hypoadrenalism [10].

Biological context of CRG

• CHARGE association-related ocular pathology in a newborn with partial trisomy 19q and partial monosomy 21q, from a maternal translocation (19;21) (q13.1;q22.3) [11].

Anatomical context of CRG

• CHARGE association with congenital glaucoma due to maldevelopment of the anterior chamber angle [12].

Associations of CRG with chemical compounds

• SEARCH STRATEGY: Trials were searched in computerized general (Medline, Embase, Psychlit, Psychindex) and specialized databases (Cochrane Complementary Medicine Field, Cochrane Depression & Neurosis CRG, Phytodok); by checking bibliographies of pertinent articles; and by contacting manufacturers and researchers [13].
• CHARGE association in a neonate exposed in utero to carbon monoxide [14].

Analytical, diagnostic and therapeutic context of CRG

• D2AM is a french CRG beamline installed at the ESRF (European Synchrotron Radiation Facility) in Grenoble, with half of the time dedicated to biological macromolecule crystallography and half to materials science studies (diffraction, wide-angle and small-angle scattering) [15].
• CRG brings ethics into NIH prenatal gene therapy debate [16].
• Of CRG patients, 43% were treated with radiation alone and 40% with surgery followed by radiotherapy [17].
• Thirteen eyes were fitted with conventional rigid gas permeable (CRGP), 10 with soft and 19 with reverse geometry rigid gas permeable contact lenses (RVG) [18].
• CHARGE association in a child with de Novo chromosomal aberration 46, X,der(X)t(X;2)(p22.1;q33) detected by spectral karyotyping [19].

References