Disease relevance of Contact Lenses

• The relationship between corneal edema and hydrogel lens oxygen transmissibility was examined for both daily and extended contact lens wear by measuring the corneal swelling response induced by a variety of contact lenses over a 36-hr wearing period [1].
• Serratia marcescens (11 of 12 strains) demonstrated an ability to grow in certain chlorhexidine-based disinfecting solutions recommended for rigid gas-permeable contact lenses [2].
• INTERVENTION: STAAR Collamer Implantable Contact Lenses (STAAR Surgical Inc., Nidau, Switzerland) were implanted for correction of high myopia and hyperopia [3].
• Pseudomonas attachment to new hydrogel contact lenses [4].
• The fibronectin in the tears and on the contact lens may predispose subjects to contamination by bacteria and thus increase the risk of inflammatory or infectious diseases associated with bacterial contamination of contact lenses [5].

High impact information on Contact Lenses

• One approach that differs from current thinking is based on the determination and monitoring of tear glucose, which is well known to track blood glucose with an approximate 30 min lag time, using disposable and colorless contact lenses [6].
• CONCLUSIONS: Bacterial transmission to the porcine cornea differed in the various types of contact lenses and was least in the hydrophilic and rough lens type [7].
• We compare the response of the boronic acid probes in the contact lens to solution-based measurements and can conclude that both the pH and polarity within the contact lens need to be considered with respect to choosing/designing and optimizing glucose-sensing probes for contact lenses [8].
• Relatively less active sPLA2 was recovered from Polymacon contact lenses. sPLA2 reduced adhesion of Staphylococcus to contact lenses in vitro [9].
• Different degrees of adherence of mucins to contact lenses may occur, either because of mucin characteristics or after mucin complexation with adherent materials [10].

Chemical compound and disease context of Contact Lenses

• Allergic hand dermatitis from 2-hydroxyethyl-acrylate in contact lenses [11].
• CONCLUSIONS: These findings demonstrate that substance P is a component of tears obtained from normal eyes of men and women ranging in age from 26 to 60 years, from eyes fitted with contact lenses, from eyes with dry eye syndrome, and from eyes 1 and 2 days after excimer laser refractive surgery [12].
• The present study was designed to evaluate the flexure and residual astigmatism of gas permeable Polycon contact lenses on toric corneas and compare the results with those obtained with PMMA lenses on the same corneas [13].
• Flexible contact lenses and our experience with 'Sauflon 70' lenses in aphakia [14].
• Allergic conjunctivitis and contact lenses: experience with olopatadine hydrochloride 0.1% therapy [15].

Biological context of Contact Lenses

• PARTICIPANTS: Fifty-two eyes of 30 patients with preoperative myopia greater than -12 D, best-corrected visual acuity (BCVA) of 20/100 or better, and intolerance of contact lenses [16].
• Furthermore, the area under the timolol concentration-time curve (AUC) was 3.3- and 8.7-fold greater for imprinted contact lenses than non-imprinted contact lenses and eyedrops, respectively [17].
• PURPOSE: To confirm the safety, efficacy, and predictability of the surgical correction of moderate to high myopia by the ICM V3 and ICM V4 implantable contact lenses (ICLs), with emphasis on vaulting, intraocular pressure (IOP), and pigment dispersion [18].
• Acanthamoeba-contaminated hydrogel contact lenses. Susceptibility to disinfection [19].
• Modulation of bacterial adhesion to hydrogel contact lenses by albumin [20].

Anatomical context of Contact Lenses

• Reduced epithelial adhesion in cat corneas after continuous wear of thick hydrogel contact lenses has been reported previously [21].
• PURPOSE: To examine the rabbit corneal epithelial cell proliferation rate after extended wear of disposable or silicone hydrogel contact lenses or prolonged eyelid closure [22].
• We studied the macrostructural characteristics of papillary changes of the upper tarsal conjunctiva associated with the wearing of polymethyl methacrylate (PMMA) contact lenses [23].
• We believe our approach offers unique opportunities for non-invasive continuous glucose monitoring for diabetics, especially since many have eye disorders and require vision correction by either contact lenses or glasses, which is thought to be due to glycation of protein in blood vessels [24].
• Short-term adaptation of the human corneal endothelium to continuous wear of silicone hydrogel (lotrafilcon A) contact lenses after daily hydrogel lens wear [25].

Associations of Contact Lenses with chemical compounds

• These contact lenses can be worn by diabetics who can colorimetrically see changes in their contact lens color or other fluorescence-based properties, giving an indication of tear and blood glucose levels [6].
• Twenty spectra were then recorded from each of 12 subjects wearing hydrogel contact lenses [26].
• Commercial contact lenses composed of copolymers of HEMA and N-vinyl pyrrolidone (NVP) or acrylamide (AAm) adsorbed small amounts of all proteins whereas copolymers of methacrylic acid (MAAc) and HEMA adsorbed much larger quantities of lysozyme [27].
• In conclusion, thimerosal-immunized rabbits show an exquisite sensitivity to the minute quantities of thimerosal conjugates adsorbed to contact lenses [28].
• METHODS: An alpha-toxin-positive parent strain (8325-4), its isogenic alpha-toxin-negative mutant (DU1090), and a genetically rescued form of the mutant (DU1090/pDU1212) were bound to rabbit-specific contact lenses, treated with spermidine (50 mM), and applied to scarified rabbit corneas [29].

Gene context of Contact Lenses

• Patterns of mucin adherence to contact lenses [10].
• Mucin balls with wear of conventional and silicone hydrogel contact lenses [30].
• Increased eotaxin in tears of patients wearing contact lenses [31].
• Recordings were between DTL fibres placed under contact lenses on the two eyes [32].
• The percentage of recovery of corneal thickness per hour (PRPH) from induced swelling proved to be significantly lower (P = 0.03) and the induced swelling proved to be significantly lower (P < 0.01) in the group wearing contact lenses than in the control group [33].

Analytical, diagnostic and therapeutic context of Contact Lenses

• To investigate the mechanism(s) underlying this observed loss of epithelial adhesion further, the corneas of both eyes of cats that had worn low-oxygen-transmissible thick parallel-design hydrogel contact lenses only in one eye for 8-121 days were examined using both light and transmission electron microscopy (TEM) [21].
• The aim of this study was to evaluate "in vivo" the usefulness of molecular imprinting technology to obtain therapeutic soft contact lenses capable of prolonging the permanence of timolol in the precorneal area, compared to conventional contact lenses and eyedrops [17].
• CONCLUSIONS: Consistent with previous work, better unaided vision, combined with the inconvenience of or intolerance to spectacles or contact lenses, provided the main incentives to have LASIK for myopia, while improved cosmesis was relatively unimportant (29.1%) [34].
• The adhesion of two strains of Pseudomonas aeruginosa to unworn hydrogel contact lenses (CLs) was studied by scanning electron microscopy [4].
• Water transport in dehydrating hydrogel contact lenses: implications for corneal desiccation [35].

References