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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Contact Lenses

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Disease relevance of Contact Lenses


High impact information on Contact Lenses

  • One approach that differs from current thinking is based on the determination and monitoring of tear glucose, which is well known to track blood glucose with an approximate 30 min lag time, using disposable and colorless contact lenses [6].
  • CONCLUSIONS: Bacterial transmission to the porcine cornea differed in the various types of contact lenses and was least in the hydrophilic and rough lens type [7].
  • We compare the response of the boronic acid probes in the contact lens to solution-based measurements and can conclude that both the pH and polarity within the contact lens need to be considered with respect to choosing/designing and optimizing glucose-sensing probes for contact lenses [8].
  • Relatively less active sPLA2 was recovered from Polymacon contact lenses. sPLA2 reduced adhesion of Staphylococcus to contact lenses in vitro [9].
  • Different degrees of adherence of mucins to contact lenses may occur, either because of mucin characteristics or after mucin complexation with adherent materials [10].

Chemical compound and disease context of Contact Lenses


Biological context of Contact Lenses


Anatomical context of Contact Lenses


Associations of Contact Lenses with chemical compounds

  • These contact lenses can be worn by diabetics who can colorimetrically see changes in their contact lens color or other fluorescence-based properties, giving an indication of tear and blood glucose levels [6].
  • Twenty spectra were then recorded from each of 12 subjects wearing hydrogel contact lenses [26].
  • Commercial contact lenses composed of copolymers of HEMA and N-vinyl pyrrolidone (NVP) or acrylamide (AAm) adsorbed small amounts of all proteins whereas copolymers of methacrylic acid (MAAc) and HEMA adsorbed much larger quantities of lysozyme [27].
  • In conclusion, thimerosal-immunized rabbits show an exquisite sensitivity to the minute quantities of thimerosal conjugates adsorbed to contact lenses [28].
  • METHODS: An alpha-toxin-positive parent strain (8325-4), its isogenic alpha-toxin-negative mutant (DU1090), and a genetically rescued form of the mutant (DU1090/pDU1212) were bound to rabbit-specific contact lenses, treated with spermidine (50 mM), and applied to scarified rabbit corneas [29].

Gene context of Contact Lenses


Analytical, diagnostic and therapeutic context of Contact Lenses


  1. Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. Holden, B.A., Mertz, G.W. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  2. Adaptation and growth of Serratia marcescens in contact lens disinfectant solutions containing chlorhexidine gluconate. Gandhi, P.A., Sawant, A.D., Wilson, L.A., Ahearn, D.G. Appl. Environ. Microbiol. (1993) [Pubmed]
  3. Outcome after treatment of ametropia with implantable contact lenses. Lackner, B., Pieh, S., Schmidinger, G., Hanselmayer, G., Dejaco-Ruhswurm, I., Funovics, M.A., Skorpik, C. Ophthalmology (2003) [Pubmed]
  4. Pseudomonas attachment to new hydrogel contact lenses. Duran, J.A., Refojo, M.F., Gipson, I.K., Kenyon, K.R. Arch. Ophthalmol. (1987) [Pubmed]
  5. Fibronectin concentration in tears of contact lens wearers. Baleriola-Lucas, C., Fukuda, M., Willcox, M.D., Sweeney, D.F., Holden, B.A. Exp. Eye Res. (1997) [Pubmed]
  6. A glucose-sensing contact lens: from bench top to patient. Badugu, R., Lakowicz, J.R., Geddes, C.D. Curr. Opin. Biotechnol. (2005) [Pubmed]
  7. Bacterial transmission from contact lenses to porcine corneas: an ex vivo study. Vermeltfoort, P.B., van Kooten, T.G., Bruinsma, G.M., Hooymans, A.M., van der Mei, H.C., Busscher, H.J. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  8. Noninvasive continuous monitoring of physiological glucose using a monosaccharide-sensing contact lens. Badugu, R., Lakowicz, J.R., Geddes, C.D. Anal. Chem. (2004) [Pubmed]
  9. Secretory phospholipase A2 deposition on contact lenses and its effect on bacterial adhesion. Hume, E.B., Cole, N., Parmar, A., Tan, M.E., Aliwarga, Y., Schubert, T., Holden, B.A., Willcox, M.D. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  10. Patterns of mucin adherence to contact lenses. Berry, M., Harris, A., Corfield, A.P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  11. Allergic hand dermatitis from 2-hydroxyethyl-acrylate in contact lenses. Peters, K., Andersen, K.E. Contact Derm. (1986) [Pubmed]
  12. Detection of substance P in human tears by laser desorption mass spectrometry and immunoassay. Varnell, R.J., Freeman, J.Y., Maitchouk, D., Beuerman, R.W., Gebhardt, B.M. Curr. Eye Res. (1997) [Pubmed]
  13. Flexure and residual astigmatism with Polycon and polymethyl methacrylate lenses on toric corneas. Harris, M.G., Kadoya, J., Nomura, J., Wong, V. American journal of optometry and physiological optics. (1982) [Pubmed]
  14. Flexible contact lenses and our experience with 'Sauflon 70' lenses in aphakia. Jain, M.R. Indian journal of ophthalmology. (1976) [Pubmed]
  15. Allergic conjunctivitis and contact lenses: experience with olopatadine hydrochloride 0.1% therapy. Brodsky, M. Acta ophthalmologica Scandinavica. Supplement. (2000) [Pubmed]
  16. Retinal detachment after clear lens extraction for high myopia: seven-year follow-up. Colin, J., Robinet, A., Cochener, B. Ophthalmology (1999) [Pubmed]
  17. Ocular release of timolol from molecularly imprinted soft contact lenses. Hiratani, H., Fujiwara, A., Tamiya, Y., Mizutani, Y., Alvarez-Lorenzo, C. Biomaterials (2005) [Pubmed]
  18. Implantable contact lens for moderate to high myopia: short-term follow-up of 2 models. Gonvers, M., Othenin-Girard, P., Bornet, C., Sickenberg, M. Journal of cataract and refractive surgery. (2001) [Pubmed]
  19. Acanthamoeba-contaminated hydrogel contact lenses. Susceptibility to disinfection. Lindquist, T.D., Doughman, D.J., Rubenstein, J.B., Moore, J.W., Campbell, R.C. Cornea (1988) [Pubmed]
  20. Modulation of bacterial adhesion to hydrogel contact lenses by albumin. Taylor, R.L., Willcox, M.D., Williams, T.J., Verran, J. Optometry and vision science : official publication of the American Academy of Optometry. (1998) [Pubmed]
  21. Reduced epithelial adhesion after extended contact lens wear correlates with reduced hemidesmosome density in cat cornea. Madigan, M.C., Holden, B.A. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  22. Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation. Ladage, P.M., Ren, D.H., Petroll, W.M., Jester, J.V., Bergmanson, J.P., Cavanagh, H.D. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  23. Biomicroscopy of papillae associated with hard contact lens wearing. Korb, D.R., Allansmith, M.R., Greiner, J.V., Henriquez, A.S., Herman, J.P., Richmond, P.P., Finnemore, V.M. Ophthalmology (1981) [Pubmed]
  24. Ophthalmic glucose sensing: a novel monosaccharide sensing disposable and colorless contact lens. Badugu, R., Lakowicz, J.R., Geddes, C.D. The Analyst. (2004) [Pubmed]
  25. Short-term adaptation of the human corneal endothelium to continuous wear of silicone hydrogel (lotrafilcon A) contact lenses after daily hydrogel lens wear. Doughty, M.J., Aakre, B.M., Ystenaes, A.E., Svarverud, E. Optometry and vision science : official publication of the American Academy of Optometry. (2005) [Pubmed]
  26. Thickness of the pre- and post-contact lens tear film measured in vivo by interferometry. Nichols, J.J., King-Smith, P.E. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  27. Adsorption of proteins from artificial tear solutions to contact lens materials. Bohnert, J.L., Horbett, T.A., Ratner, B.D., Royce, F.H. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  28. Ocular hypersensitivity to thimerosal in rabbits. Baines, M.G., Cai, F., Backman, H.A. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  29. Staphylococcus corneal virulence in a new topical model of infection. Hume, E.B., Dajcs, J.J., Moreau, J.M., Sloop, G.D., Willcox, M.D., O'Callaghan, R.J. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  30. Mucin balls with wear of conventional and silicone hydrogel contact lenses. Tan, J., Keay, L., Jalbert, I., Naduvilath, T.J., Sweeney, D.F., Holden, B.A. Optometry and vision science : official publication of the American Academy of Optometry. (2003) [Pubmed]
  31. Increased eotaxin in tears of patients wearing contact lenses. Moschos, M.M., Eperon, S., Guex-Crosier, Y. Cornea (2004) [Pubmed]
  32. The scotopic threshold response of the dark-adapted electroretinogram of the mouse. Saszik, S.M., Robson, J.G., Frishman, L.J. J. Physiol. (Lond.) (2002) [Pubmed]
  33. Morphology and function of the corneal endothelium after long-term contact lens wear. Nieuwendaal, C.P., Odenthal, M.T., Kok, J.H., Venema, H.W., Oosting, J., Riemslag, F.C., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  34. Defining the content of patient questionnaires: reasons for seeking laser in situ keratomileusis for myopia. Khan-Lim, D., Craig, J.P., McGhee, C.N. Journal of cataract and refractive surgery. (2002) [Pubmed]
  35. Water transport in dehydrating hydrogel contact lenses: implications for corneal desiccation. Martin, D.K. J. Biomed. Mater. Res. (1995) [Pubmed]
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