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Gene Review

Fbn2  -  fibrillin 2

Mus musculus

Synonyms: BC063774, Fbn-2, Fib-2, Fibrillin-2, Sne, ...
 
 
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Disease relevance of Fbn2

 

High impact information on Fbn2

 

Biological context of Fbn2

 

Anatomical context of Fbn2

 

Other interactions of Fbn2

  • Restriction fragment length polymorphisms (RFLPs) between the progenitors of an interspecific backcross involving AEJ/Gn and Mus spretus mice were used to establish the segregation patterns of the murine homologs, Fbn1 and Fbn2, in the backcross progeny [7].
  • The results position Fbn2 between the D18Mit35 and Pdgfrb loci in the central region of mouse Chr 18 [7].
 

Analytical, diagnostic and therapeutic context of Fbn2

References

  1. Mutation of the gene encoding fibrillin-2 results in syndactyly in mice. Chaudhry, S.S., Gazzard, J., Baldock, C., Dixon, J., Rock, M.J., Skinner, G.C., Steel, K.P., Kielty, C.M., Dixon, M.J. Hum. Mol. Genet. (2001) [Pubmed]
  2. Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences. Charbonneau, N.L., Dzamba, B.J., Ono, R.N., Keene, D.R., Corson, G.M., Reinhardt, D.P., Sakai, L.Y. J. Biol. Chem. (2003) [Pubmed]
  3. The fibrillins. Ramirez, F., Pereira, L. Int. J. Biochem. Cell Biol. (1999) [Pubmed]
  4. Regulation of limb patterning by extracellular microfibrils. Arteaga-Solis, E., Gayraud, B., Lee, S.Y., Shum, L., Sakai, L., Ramirez, F. J. Cell Biol. (2001) [Pubmed]
  5. Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils. Zhang, H., Hu, W., Ramirez, F. J. Cell Biol. (1995) [Pubmed]
  6. Fibrillins 1 and 2 perform partially overlapping functions during aortic development. Carta, L., Pereira, L., Arteaga-Solis, E., Lee-Arteaga, S.Y., Lenart, B., Starcher, B., Merkel, C.A., Sukoyan, M., Kerkis, A., Hazeki, N., Keene, D.R., Sakai, L.Y., Ramirez, F. J. Biol. Chem. (2006) [Pubmed]
  7. Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome. Goldstein, C., Liaw, P., Jimenez, S.A., Buchberg, A.M., Siracusa, L.D. Mamm. Genome (1994) [Pubmed]
  8. Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Schaefer, L., Mihalik, D., Babelova, A., Krzyzankova, M., Gröne, H.J., Iozzo, R.V., Young, M.F., Seidler, D.G., Lin, G., Reinhardt, D.P., Schaefer, R.M. Am. J. Pathol. (2004) [Pubmed]
  9. TGF-beta1 binding protein-like modules of fibrillin-1 and -2 mediate integrin-dependent cell adhesion. D'Arrigo, C., Burl, S., Withers, A.P., Dobson, H., Black, C., Boxer, M. Connect. Tissue Res. (1998) [Pubmed]
  10. Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment. Ritty, T.M., Broekelmann, T.J., Werneck, C.C., Mecham, R.P. Biochem. J. (2003) [Pubmed]
  11. Assembly of epithelial cell fibrillins. Dzamba, B.J., Keene, D.R., Isogai, Z., Charbonneau, N.L., Karaman-Jurukovska, N., Simon, M., Sakai, L.Y. J. Invest. Dermatol. (2001) [Pubmed]
  12. Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18. Li, X., Pereira, L., Zhang, H., Sanguineti, C., Ramirez, F., Bonadio, J., Francke, U. Genomics (1993) [Pubmed]
  13. Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin. Samuel, C.S., Sakai, L.Y., Amento, E.P. Arch. Biochem. Biophys. (2003) [Pubmed]
 
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