Gene Review:
Pdgfrb - platelet derived growth factor receptor,...
Mus musculus
Synonyms:
AI528809, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140b, ...
Roberts,
Whalen,
Soderstrom,
Moraski,
Lyssikatos,
Wang,
Cooper,
Baker,
Savage,
Dalvie,
Atherton,
Ralston,
Szewc,
Kath,
Lin,
Soderstrom,
Tkalcevic,
Cohen,
Pollack,
Barth,
Hungerford,
Ung,
Baker,
Trevino,
Summy,
Zhang,
Caron,
Nesbit,
Gallick,
Fidler,
Udagawa,
Nimura,
Otani,
Narita,
Usui,
Narita,
Niikura,
Nozaki,
Khotib,
Nagumo,
Yajima,
Suzuki,
- Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis. Shih, A.H., Dai, C., Hu, X., Rosenblum, M.K., Koutcher, J.A., Holland, E.C. Cancer Res. (2004)
- Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice. Baker, C.H., Trevino, J.G., Summy, J.M., Zhang, F., Caron, A., Nesbit, M., Gallick, G.E., Fidler, I.J. Int. J. Oncol. (2006)
- Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice. Sano, H., Sudo, T., Yokode, M., Murayama, T., Kataoka, H., Takakura, N., Nishikawa, S., Nishikawa, S.I., Kita, T. Circulation (2001)
- Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer. Kim, S.J., Uehara, H., Yazici, S., Busby, J.E., Nakamura, T., He, J., Maya, M., Logothetis, C., Mathew, P., Wang, X., Do, K.A., Fan, D., Fidler, I.J. J. Natl. Cancer Inst. (2006)
- Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Roberts, W.G., Whalen, P.M., Soderstrom, E., Moraski, G., Lyssikatos, J.P., Wang, H.F., Cooper, B., Baker, D.A., Savage, D., Dalvie, D., Atherton, J.A., Ralston, S., Szewc, R., Kath, J.C., Lin, J., Soderstrom, C., Tkalcevic, G., Cohen, B.D., Pollack, V., Barth, W., Hungerford, W., Ung, E. Cancer Res. (2005)
- A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Ding, H., Wu, X., Boström, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G.Y., Soriano, P., Betsholtz, C., Hart, T.C., Marazita, M.L., Field, L.L., Tam, P.P., Nagy, A. Nat. Genet. (2004)
- Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages. Crosby, J.R., Seifert, R.A., Soriano, P., Bowen-Pope, D.F. Nat. Genet. (1998)
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Franke, T.F., Yang, S.I., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R., Tsichlis, P.N. Cell (1995)
- Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury. Narita, M., Usui, A., Narita, M., Niikura, K., Nozaki, H., Khotib, J., Nagumo, Y., Yajima, Y., Suzuki, T. J. Neurosci. (2005)
- LRP: role in vascular wall integrity and protection from atherosclerosis. Boucher, P., Gotthardt, M., Li, W.P., Anderson, R.G., Herz, J. Science (2003)
- Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Plattner, R., Koleske, A.J., Kazlauskas, A., Pendergast, A.M. Mol. Cell. Biol. (2004)
- Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Rolny, C., Lu, L., Agren, N., Nilsson, I., Roe, C., Webb, G.C., Welsh, M. Exp. Cell Res. (2005)
- Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways. Tallquist, M.D., Klinghoffer, R.A., Heuchel, R., Mueting-Nelsen, P.F., Corrin, P.D., Heldin, C.H., Johnson, R.J., Soriano, P. Genes Dev. (2000)
- Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. DeMali, K.A., Kazlauskas, A. Mol. Cell. Biol. (1998)
- Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice. Kaminski, W.E., Lindahl, P., Lin, N.L., Broudy, V.C., Crosby, J.R., Hellström, M., Swolin, B., Bowen-Pope, D.F., Martin, P.J., Ross, R., Betsholtz, C., Raines, E.W. Blood (2001)
- Molecular profiles of the mouse postnatal development of the esophageal epithelium showing delayed growth start. Daiko, H., Isohata, N., Sano, M., Aoyagi, K., Ogawa, K., Kameoka, S., Yoshida, T., Sasaki, H. Int. J. Mol. Med. (2006)
- A colony-stimulating factor 1 (CSF-1) receptor/platelet-derived growth factor-beta receptor gene fusion confers CSF-1 independence and tumorigenicity on a c-myc-immortalized monocyte cell line. Eccles, M.R., King, F.J., Cole, M.D. Mol. Cell. Biol. (1992)
- Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions. Heidaran, M.A., Beeler, J.F., Yu, J.C., Ishibashi, T., LaRochelle, W.J., Pierce, J.H., Aaronson, S.A. J. Biol. Chem. (1993)
- p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. Uramoto, H., Wetterskog, D., Hackzell, A., Matsumoto, Y., Funa, K. J. Cell. Sci. (2004)
- The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Goparaju, S.K., Jolly, P.S., Watterson, K.R., Bektas, M., Alvarez, S., Sarkar, S., Mel, L., Ishii, I., Chun, J., Milstien, S., Spiegel, S. Mol. Cell. Biol. (2005)
- Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse. Chen, X., Aravindakshan, J., Yang, Y., Tiwari-Pandey, R., Sairam, M.R. Carcinogenesis (2006)
- Src family kinases are required for integrin but not PDGFR signal transduction. Klinghoffer, R.A., Sachsenmaier, C., Cooper, J.A., Soriano, P. EMBO J. (1999)
- Functional importance of platelet-derived growth factor (PDGF) receptor extracellular immunoglobulin-like domains. Identification of PDGF binding site and neutralizing monoclonal antibodies. Lokker, N.A., O'Hare, J.P., Barsoumian, A., Tomlinson, J.E., Ramakrishnan, V., Fretto, L.J., Giese, N.A. J. Biol. Chem. (1997)
- Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration. Yu, J., Moon, A., Kim, H.R. Biochem. Biophys. Res. Commun. (2001)
- Singlet oxygen-induced activation of Akt/protein kinase B is independent of growth factor receptors. Zhuang, S., Kochevar, I.E. Photochem. Photobiol. (2003)
- Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. Cho, H., Kozasa, T., Bondjers, C., Betsholtz, C., Kehrl, J.H. FASEB J. (2003)
- TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma. Crowley, M.R., Bowtell, D., Serra, R. Dev. Biol. (2005)
- Evidence for a role of NF-kappaB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL/platelet-derived growth factor receptor beta fusion protein. Besançon, F., Atfi, A., Gespach, C., Cayre, Y.E., Bourgeade, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome. Goldstein, C., Liaw, P., Jimenez, S.A., Buchberg, A.M., Siracusa, L.D. Mamm. Genome (1994)
- Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. Pitera, J.E., Woolf, A.S., Gale, N.W., Yancopoulos, G.D., Yuan, H.T. Am. J. Pathol. (2004)
- Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice. Basciani, S., Mariani, S., Arizzi, M., Brama, M., Ricci, A., Betsholtz, C., Bondjers, C., Ricci, G., Catizone, A., Galdieri, M., Spera, G., Gnessi, L. Biol. Reprod. (2004)
- SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Patyna, S., Laird, A.D., Mendel, D.B., O'farrell, A.M., Liang, C., Guan, H., Vojkovsky, T., Vasile, S., Wang, X., Chen, J., Grazzini, M., Yang, C.Y., Haznedar, J.O., Sukbuntherng, J., Zhong, W.Z., Cherrington, J.M., Hu-Lowe, D. Mol. Cancer Ther. (2006)
- Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex. Udagawa, J., Nimura, M., Otani, H. Neuro Endocrinol. Lett. (2006)
- Down-regulation of platelet-derived growth factor receptor expression during terminal differentiation of 3T3-L1 pre-adipocyte fibroblasts. Vaziri, C., Faller, D.V. J. Biol. Chem. (1996)
- Downregulation of platelet-derived growth factor receptor-beta in Shp-2 mutant fibroblast cell lines. Lu, X., Qu, C.K., Shi, Z.Q., Feng, G.S. Oncogene (1998)