Disease relevance of Hagh

• Determinations were made of glyoxalase I and glyoxalase II acitivity in the liver of mice (BDF1 and DBA2 strains) bearing sarcoma 180 and L1210 leukemia in ascites form [1].

High impact information on Hagh

• Swiss albino mice (male) were irradiated with gamma-rays at a dose-rate of 0.05 Gy s-1, and the activities of glyoxalase I (GI) and glyoxalase II (GII) were determined after 24 h in the spleen and liver [2].
• GSH and caffeine increased and chlorpromazine decreased the radiation-induced activity of GI, but all three modifiers enhanced radiation-induced inactivation of GII [3].
• Swiss albino mice (7-8 weeks old) were irradiated with different doses (0-25 Gy) of gamma-radiation at a dose-rate of 0.05 Gy/s. The specific activities of glyoxalase I (GI) and glyoxalase II (GII) were determined in the spleen and liver immediately and on the 3rd and 6th day postirradiation [3].
• Gene loci for phosphoglycolate phosphatase and hydroxyacyl glutathione hydrolase were localized within human chromosome band 16p13 [4].
• The activities of glyoxalase II and glutathione S-transferase were not affected by the treatment [5].

Associations of Hagh with chemical compounds

• Effect of radiation on glyoxalase I and glyoxalase II activities in spleen and liver of mice [3].
• 1. Mouse liver glyoxalase II is competitively inhibited by the substrate of glyoxalase I (the hemimercaptal of methylglyoxal and glutathione); the Ki is 0.3 mM [6].

Other interactions of Hagh

• Further studies on liver glyoxalase I and glyoxalase II. Activity in mice bearing sarcoma 180 and L1210 leukemia [1].

Analytical, diagnostic and therapeutic context of Hagh

• A progressive decrease in the both glyoxalase I and glyoxalase II activities to about 40--60% of that of the control groups was observed within the developing period 8--9 days [1].

References