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Gene Review

HAGH  -  hydroxyacylglutathione hydrolase

Homo sapiens

Synonyms: GLO2, GLX2, GLXII, Glx II, Glyoxalase II, ...
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Disease relevance of HAGH


High impact information on HAGH


Chemical compound and disease context of HAGH


Biological context of HAGH


Anatomical context of HAGH


Associations of HAGH with chemical compounds


Other interactions of HAGH


Analytical, diagnostic and therapeutic context of HAGH


  1. Molecular cloning, heterologous expression, and characterization of human glyoxalase II. Ridderström, M., Saccucci, F., Hellman, U., Bergman, T., Principato, G., Mannervik, B. J. Biol. Chem. (1996) [Pubmed]
  2. Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas. Mearini, E., Romani, R., Mearini, L., Antognelli, C., Zucchi, A., Baroni, T., Porena, M., Talesa, V.N. Eur. J. Cancer (2002) [Pubmed]
  3. Glyoxalase enzyme system in human muscular dystrophy. Kar, N.C., Pearson, C.M. Clin. Chim. Acta (1975) [Pubmed]
  4. Glyoxalase activities in tumor and non-tumor human urogenital tissues. Di Ilio, C., Angelucci, S., Pennelli, A., Zezza, A., Tenaglia, R., Sacchetta, P. Cancer Lett. (1995) [Pubmed]
  5. Platelet glyoxalases in thrombocytosis. Leoncini, G., Maresca, M., Balestrero, F., Armani, U., Piana, A. Scandinavian journal of haematology. (1984) [Pubmed]
  6. Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. Shinohara, M., Thornalley, P.J., Giardino, I., Beisswenger, P., Thorpe, S.R., Onorato, J., Brownlee, M. J. Clin. Invest. (1998) [Pubmed]
  7. An unusual "morphologic" variant of BF S. Raum, D., Surgenor, T., Awdeh, Z., Marcus, D., Blumenthal, M., Yunis, E.J., Alper, C.A. Am. J. Hum. Genet. (1984) [Pubmed]
  8. Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. Awdeh, Z.L., Raum, D., Yunis, E.J., Alper, C.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  9. A new rare variant of the glyoxalase I system of the red cell: GLO-Sicily. Beretta, M., Schilirò, G., Russo, A., Barbujani, G., Mazzetti, P., Russo, G., Barrai, I. Am. J. Hum. Genet. (1983) [Pubmed]
  10. Increased levels of methylglyoxal-metabolizing enzymes in mononuclear and polymorphonuclear cells from insulin-dependent diabetic patients with diabetic complications: aldose reductase, glyoxalase I, and glyoxalase II--a clinical research center study. Ratliff, D.M., Vander Jagt, D.J., Eaton, R.P., Vander Jagt, D.L. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  11. Overexpression of glyoxalase system enzymes in human kidney tumor. Antognelli, C., Baldracchini, F., Talesa, V.N., Costantini, E., Zucchi, A., Mearini, E. Cancer journal (Sudbury, Mass.) (2006) [Pubmed]
  12. New regional localisations for HAGH and PGP on human chromosome 16. Mulley, J.C., Callen, D.F. Hum. Genet. (1986) [Pubmed]
  13. Assignment of the glyoxalase II gene (HAGH) to human chromosome 16. Honey, N.K., Shows, T.B. Hum. Genet. (1981) [Pubmed]
  14. The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway. Lee, H.Y., Xu, Y., Huang, Y., Ahn, A.H., Auburger, G.W., Pandolfo, M., Kwiecinski, H., Grimes, D.A., Lang, A.E., Nielsen, J.E., Averyanov, Y., Servidei, S., Friedman, A., Van Bogaert, P., Abramowicz, M.J., Bruno, M.K., Sorensen, B.F., Tang, L., Fu, Y.H., Ptácek, L.J. Hum. Mol. Genet. (2004) [Pubmed]
  15. Genetic polymorphism of human erythrocyte glyoxalase II. Board, P.G. Am. J. Hum. Genet. (1980) [Pubmed]
  16. The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. Cordell, P.A., Futers, T.S., Grant, P.J., Pease, R.J. J. Biol. Chem. (2004) [Pubmed]
  17. Demonstration of glyoxalase II in rat liver mitochondria. Partial purification and occurrence in multiple forms. Talesa, V., Uotila, L., Koivusalo, M., Principato, G., Giovannini, E., Rosi, G. Biochim. Biophys. Acta (1988) [Pubmed]
  18. Expression of glyoxalase I and II in normal and breast cancer tissues. Rulli, A., Carli, L., Romani, R., Baroni, T., Giovannini, E., Rosi, G., Talesa, V. Breast Cancer Res. Treat. (2001) [Pubmed]
  19. Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue. Cameron, A.D., Ridderström, M., Olin, B., Mannervik, B. Structure (1999) [Pubmed]
  20. Glyoxalase II of African trypanosomes is trypanothione-dependent. Irsch, T., Krauth-Siegel, R.L. J. Biol. Chem. (2004) [Pubmed]
  21. Trace metals and variations of antioxidant enzymes in Arctic bivalve populations. Regoli, F., Hummel, H., Amiard-Triquet, C., Larroux, C., Sukhotin, A. Arch. Environ. Contam. Toxicol. (1998) [Pubmed]
  22. Polymorphism of red cell glyoxalase I (EI:; a new genetic marker in man. Investigation of 169 mother-child combinations. Kömpf, J., Bissbort, S., Gussmann, S., Ritter, H. Humangenetik. (1975) [Pubmed]
  23. C4*A6BQO: a 'new' C4 haplotype. Skanes, V., Larsen, B. J. Immunogenet. (1984) [Pubmed]
  24. Specific interaction of cytosolic and mitochondrial glyoxalase II with acidic phospholipids in form of liposomes results in the inhibition of the cytosolic enzyme only. Scirè, A., Tanfani, F., Saccucci, F., Bertoli, E., Principato, G. Proteins (2000) [Pubmed]
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