Gene Review:
Ephx1 - epoxide hydrolase 1, microsomal
Mus musculus
Synonyms:
AI195553, Eph-1, Eph1, Epoxide hydratase, Epoxide hydrolase 1, ...
- Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. Miyata, M., Kudo, G., Lee, Y.H., Yang, T.J., Gelboin, H.V., Fernandez-Salguero, P., Kimura, S., Gonzalez, F.J. J. Biol. Chem. (1999)
- Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems. Massaad, L., de Waziers, I., Ribrag, V., Janot, F., Beaune, P.H., Morizet, J., Gouyette, A., Chabot, G.G. Cancer Res. (1992)
- Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences. Oesch, F., Schmassmann, H., Ohnhaus, E., Althaus, U., Lorenz, J. Carcinogenesis (1980)
- Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in SKH-1 hairless mice. Das, M., Bickers, D.R., Santella, R.M., Mukhtar, H. J. Invest. Dermatol. (1985)
- Hepatotoxicity of germander in mice. Loeper, J., Descatoire, V., Letteron, P., Moulis, C., Degott, C., Dansette, P., Fau, D., Pessayre, D. Gastroenterology (1994)
- Epoxide hydrolase activity in the mitochondrial fraction of mouse liver. Gill, S.S., Hammock, B.D. Nature (1981)
- Rapid purification of cytosolic epoxide hydrolase from normal and clofibrate-treated animals by affinity chromatography. Prestwich, G.D., Hammock, B.D. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Hu, X., Roberts, J.R., Apopa, P.L., Kan, Y.W., Ma, Q. Mol. Cell. Biol. (2006)
- Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. Dinkova-Kostova, A.T., Abeygunawardana, C., Talalay, P. J. Med. Chem. (1998)
- Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase. Blomster, M., Wetterholm, A., Mueller, M.J., Haeggström, J.Z. Eur. J. Biochem. (1995)
- Metabolism of styrene oxide to styrene glycol by mouse liver and lung. Carlson, G.P. J. Toxicol. Environ. Health Part A (1998)
- Assessment of possible protective roles of selenium, zinc, and cis-stilbene oxide against acute T-2 toxin poisoning: a preliminary report. Yazdanpanah, H., Roshanzamir, F., Shafaghi, B., Faizi, M., Elhami, M., Rasekh, H.R. Nat. Toxins (1997)
- The Ephx1(d) allele encoding an Arg338Cys substitution is associated with heat lability. Hartsfield, J.K., Everett, E.T. Mamm. Genome (2000)
- Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. Lyman, S.D., Poland, A., Taylor, B.A. J. Biol. Chem. (1980)
- Epoxide metabolism in the liver of mice treated with clofibrate (ethyl-alpha-(p-chlorophenoxyisobutyrate], a peroxisome proliferator. Moody, D.E., Loury, D.N., Hammock, B.D. Toxicol. Appl. Pharmacol. (1985)
- Partial hepatoprotective effects of allylthiobenzimidazole in the absence of cytochrome P4502E1 suppression: effects on epoxide hydrolase, rGSTA2, rGSTA3/5, rGSTM1 and rGSTM2 expression. Kim, S.G., Lee, A.K., Kim, N.D. Xenobiotica (1998)
- The effect of tridiphane (2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane) on hepatic epoxide-metabolizing enzymes: indications of peroxisome proliferation. Moody, D.E., Hammock, B.D. Toxicol. Appl. Pharmacol. (1987)
- Cytosolic and microsomal epoxide hydrolases are immunologically distinguishable from each other in the rat and mouse. Guenthner, T.M., Hammock, B.D., Vogel, U., Oesch, F. J. Biol. Chem. (1981)
- Organ distribution of epoxide hydrolases in cytosolic and microsomal fractions of normal and nafenopin-treated male DBA/2 mice. Waechter, F., Bentley, P., Bieri, F., Muakkassah-Kelly, S., Stäubli, W., Villermain, M. Biochem. Pharmacol. (1988)
- Distribution and nature of epoxide hydrolase activity in subcellular organelles of mouse liver. Kaur, S., Gill, S.S. Biochem. Pharmacol. (1986)
- Selective inhibition of cytosolic epoxide hydrolase activity in vitro by compounds that inhibit catalase. Guenthner, T.M., Hjelle, J.T., Whalen, R. J. Biochem. Toxicol. (1989)
- Effects of hepatic inducers on testicular epoxide-metabolizing enzymes in the rat and mouse. DiBiasio, K.W., Silva, M.H., Hammock, B.D., Shull, L.R. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1989)
- Metabolic inactivation of five glycidyl ethers in lung and liver of humans, rats and mice in vitro. Boogaard, P.J., de Kloe, K.P., Bierau, J., Kuiken, G., Borkulo, P.E., Watson, W.P., van Sittert, N.J. Xenobiotica (2000)
- Metabolic inactivation of 2-oxiranylmethyl 2-ethyl-2,5-dimethylhexanoate (C10GE) in skin, lung and liver of human, rat and mouse. Boogaard, P.J., van Elburg, P.A., de Kloe, K.P., Watson, W.P., van Sittert, N.J. Xenobiotica (1999)
- Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid. Implications for the epoxide hydrolase mechanism. Andberg, M.B., Hamberg, M., Haeggström, J.Z. J. Biol. Chem. (1997)
- Effects of perfluoro fatty acids on xenobiotic-metabolizing enzymes, enzymes which detoxify reactive forms of oxygen and lipid peroxidation in mouse liver. Permadi, H., Lundgren, B., Andersson, K., DePierre, J.W. Biochem. Pharmacol. (1992)
- Spectrophotometric substrates for cytosolic epoxide hydrolase. Dietze, E.C., Kuwano, E., Hammock, B.D. Anal. Biochem. (1994)
- Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Purification procedure and physiochemical characterization of the pure enzymes. Meijer, J., Depierre, J.W. Eur. J. Biochem. (1985)