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Gene Review

SH  -  SH

Bovine respiratory syncytial virus

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Disease relevance of SH


High impact information on SH

  • From the Vbac cell line, viruses that lacked the SH and F open reading frames (ORFs) or the SH, G, and F ORFs could be recovered from cDNAs [5].
  • Furthermore, the SH-minus virus grew somewhat better (up to 12.6-fold) than wild-type recombinant RSV in certain cell lines [1].
  • On monolayers of HEp-2 cells, the SH-minus virus produced syncytia which were at least equivalent in size to those of the wild type and produced plaques which were 70% larger [1].
  • Recombinant virus containing this engineered deletion was recovered, and the absence of the SH gene was confirmed by reverse transcription in conjunction with PCR [1].
  • RESULTS: In MI-rats heart rate was similar to SH-rats, mean arterial pressure was lower and both BRS and HRV were markedly reduced [6].

Chemical compound and disease context of SH


Biological context of SH


Anatomical context of SH


Associations of SH with chemical compounds

  • Zatebradine (0.5 mg/kg i.v.) reduced heart rate in MI-rats from 400 +/- 15 to 350 +/- 19 and in SH-rats from 390 +/- 19 to 324 +/- 6 beats/min without changing mean arterial pressure [6].
  • The deletion mutants were used to study the role of the F glycoprotein and the contributions of SH and G with respect to virus attachment [2].

Analytical, diagnostic and therapeutic context of SH

  • Northern blot analysis of intracellular RNAs and gel electrophoresis of labeled intracellular proteins confirmed the lack of expression of the SH mRNA and protein [1].


  1. Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. Bukreyev, A., Whitehead, S.S., Murphy, B.R., Collins, P.L. J. Virol. (1997) [Pubmed]
  2. Recombinant bovine respiratory syncytial virus with deletions of the G or SH genes: G and F proteins bind heparin. Karger, A., Schmidt, U., Buchholz, U.J. J. Gen. Virol. (2001) [Pubmed]
  3. UL-FS 49 (zatebradine) does not affect arterial baroreflex in conscious normal or aortic-constricted rats. Sakamoto, M., Siri, F.M., Solomon, S.B., Tanimoto, H., Yellin, E.L. J. Cardiovasc. Pharmacol. (1998) [Pubmed]
  4. Baroreflex sensitivity and heart rate variability in conscious rats with myocardial infarction. Krüger, C., Kalenka, A., Haunstetter, A., Schweizer, M., Maier, C., Rühle, U., Ehmke, H., Kübler, W., Haass, M. Am. J. Physiol. (1997) [Pubmed]
  5. trans-Complementation allows recovery of human respiratory syncytial viruses that are infectious but deficient in cell-to-cell transmission. Oomens, A.G., Wertz, G.W. J. Virol. (2004) [Pubmed]
  6. The bradycardic agent zatebradine enhances baroreflex sensitivity and heart rate variability in rats early after myocardial infarction. Krüger, C., Landerer, V., Zugck, C., Ehmke, H., Kübler, W., Haass, M. Cardiovasc. Res. (2000) [Pubmed]
  7. Analysis of bovine respiratory syncytial virus envelope glycoproteins in cell fusion. Pastey, M.K., Samal, S.K. J. Gen. Virol. (1997) [Pubmed]
  8. Nucleotide and predicted amino acid sequence analysis of the ovine respiratory syncytial virus non-structural 1C and 1B genes and the small hydrophobic protein gene. Alansari, H., Potgieter, L.N. J. Gen. Virol. (1994) [Pubmed]
  9. Modeling the structure of the respiratory syncytial virus small hydrophobic protein by silent-mutation analysis of global searching molecular dynamics. Kochva, U., Leonov, H., Arkin, I.T. Protein Sci. (2003) [Pubmed]
  10. Nucleotide sequence analysis of a matrix and small hydrophobic protein dicistronic mRNA of bovine respiratory syncytial virus demonstrates extensive sequence divergence of the small hydrophobic protein from that of human respiratory syncytial virus. Samal, S.K., Zamora, M. J. Gen. Virol. (1991) [Pubmed]
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