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MeSH Review

Reflex, Abnormal

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Disease relevance of Reflex, Abnormal


High impact information on Reflex, Abnormal

  • Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice [6].
  • Because VR1 represents an attractive therapeutic target for conditions ranging from long-term pain to bladder hyperreflexia, we and other groups have sought to develop novel ligands with enhanced potencies and novel pharmacological properties [7].
  • Losartan decreased reflex control of LSNA more in LS than in HS rats (P < .05), as indicated by reductions in maximum LSNA (98 +/- 2 to 78 +/- 3% max) and minimum LSNA (42 +/- 5 to 21 +/- 5% max) [8].
  • Urodynamic studies, performed on all 19 incontinent patients, revealed bladder hyperreflexia in 37%, normal studies in 37%, bladder hyporeflexia in 21%, and detrusor-sphincter dyssynergia in 5% [9].
  • The neuropathy affected proximal and distal muscles, demonstrated hyporeflexia or areflexia, and usually had elevated CSF protein [10].

Chemical compound and disease context of Reflex, Abnormal


Biological context of Reflex, Abnormal


Anatomical context of Reflex, Abnormal

  • We investigated the selective peptide tachykinin antagonists MEN 11420 and GR 82334 of NK-2 and NK-1 receptors, respectively, in a chronic rat model of detrusor hyperreflexia after suprasacral spinal cord injury [21].
  • CYP administration produced a marked detrusor hyperreflexia which was abolished by capsaicin pretreatment, demonstrating that it is mediated through stimulation of capsaicin-sensitive afferent neurons [22].
  • The presence of TNFR1 receptors, and perhaps their long-term activation or plasticity, may also play a critical role in the chronic allodynia and hyperreflexia observed after SCI or peripheral nerve damage [23].
  • The ID50 in LP-805-treated rats (0.03 mg/kg i.v.) was lower than that in normal rats (0.56 mg/kg i.v.). After chronic irritation of the bladder epithelium, MK-801 sensitivity was enhanced for the micturition reflex.These data suggested that crystalluria elicit hyperreflexia in the micturition reflex that mediated with NMDA glutamatergic receptors [24].

Gene context of Reflex, Abnormal


Analytical, diagnostic and therapeutic context of Reflex, Abnormal


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  3. Late-onset SCA2: 33 CAG repeats are sufficient to cause disease. Fernandez, M., McClain, M.E., Martinez, R.A., Snow, K., Lipe, H., Ravits, J., Bird, T.D., La Spada, A.R. Neurology (2000) [Pubmed]
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  5. Posture- and emotion-induced severe hypertensive paroxysms with baroreceptor dysfunction. Kuchel, O., Cusson, J.R., Larochelle, P., Buu, N.T., Genest, J. J. Hypertens. (1987) [Pubmed]
  6. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Cockayne, D.A., Hamilton, S.G., Zhu, Q.M., Dunn, P.M., Zhong, Y., Novakovic, S., Malmberg, A.B., Cain, G., Berson, A., Kassotakis, L., Hedley, L., Lachnit, W.G., Burnstock, G., McMahon, S.B., Ford, A.P. Nature (2000) [Pubmed]
  7. High-affinity partial agonists of the vanilloid receptor. Wang, Y., Toth, A., Tran, R., Szabo, T., Welter, J.D., Blumberg, P.M., Lee, J., Kang, S.U., Lim, J.O., Lee, J. Mol. Pharmacol. (2003) [Pubmed]
  8. Sodium intake, angiotensin II receptor blockade, and baroreflex function in conscious rats. Xu, L., Brooks, V.L. Hypertension (1997) [Pubmed]
  9. Causes of urinary incontinence after acute hemispheric stroke. Gelber, D.A., Good, D.C., Laven, L.J., Verhulst, S.J. Stroke (1993) [Pubmed]
  10. Polyneuropathy complicating bone marrow and solid organ transplantation. Amato, A.A., Barohn, R.J., Sahenk, Z., Tutschka, P.J., Mendell, J.R. Neurology (1993) [Pubmed]
  11. Hyperreflexia of the urinary bladder: possible role of the efferent function of the capsaicin sensitive primary afferents. Shaker, H.S., Tu, L.M., Kalfopoulos, M., Hassouna, M., Dion, S., Elhilali, M. J. Urol. (1998) [Pubmed]
  12. Spinal carbonic anhydrase contributes to nociceptive reflex enhancement by midazolam, pentobarbital, and propofol. Wang, B., Samanani, N., Roth, S.H., Archer, D.P. Anesthesiology (2003) [Pubmed]
  13. Inhibition of hyperreflexia by vaginally administered oxybutynin: a novel rabbit model. Chou, E.C., Whitbeck, C., Borow, A., Burden, O., Levin, R.M. J. Urol. (2004) [Pubmed]
  14. Role of spinal nitric oxide synthase-dependent processes in the initiation of the micturition hyperreflexia associated with cyclophosphamide-induced cystitis. Lagos, P., Ballejo, G. Neuroscience (2004) [Pubmed]
  15. Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat. Woods, M., Carson, N., Norton, N.W., Sheldon, J.H., Argentieri, T.M. J. Urol. (2001) [Pubmed]
  16. Oculomotor, auditory, and vestibular responses in myotonic dystrophy. Verhagen, W.I., ter Bruggen, J.P., Huygen, P.L. Arch. Neurol. (1992) [Pubmed]
  17. Role of angiotensin II in altered baroreflex function of conscious rabbits during late pregnancy. Brooks, V.L., Welch, L.S., Kane, C.M. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  18. The effects of prenatal cocaine use on neonatal neurobehavioral status. Richardson, G.A., Hamel, S.C., Goldschmidt, L., Day, N.L. Neurotoxicology and teratology. (1996) [Pubmed]
  19. Change of vanilloid receptor 1 following neuromodulation in rats with spinal cord injury. Zhou, Y., Wang, Y., Abdelhady, M., Mourad, M.S., Hassouna, M.M. J. Surg. Res. (2002) [Pubmed]
  20. Neurologic findings in vitamin E deficiency. Tanyel, M.C., Mancano, L.D. American family physician. (1997) [Pubmed]
  21. Evidence of a peripheral role of neurokinins in detrusor hyperreflexia: a further study of selective tachykinin antagonists in chronic spinal injured rats. Abdel-Gawad, M., Dion, S.B., Elhilali, M.M. J. Urol. (2001) [Pubmed]
  22. Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents. Maggi, C.A., Lecci, A., Santicioli, P., Del Bianco, E., Giuliani, S. J. Auton. Nerv. Syst. (1992) [Pubmed]
  23. Immunocytochemical localization of TNF type 1 and type 2 receptors in the rat spinal cord. Holmes, G.M., Hebert, S.L., Rogers, R.C., Hermann, G.E. Brain Res. (2004) [Pubmed]
  24. MK-801 inhibits the micturition reflex in chronic bladder irritation caused by crystalluria in the rat. Ishida, F., Sato, T., Imaizumi, M., Funayama, N., Ikegami, K., Nimura, T., Kawatani, M. Autonomic neuroscience : basic & clinical. (2003) [Pubmed]
  25. Clinical aspects of the disorders of GABA metabolism in children. Pearl, P.L., Gibson, K.M. Curr. Opin. Neurol. (2004) [Pubmed]
  26. Effect of tachykinin NK2 receptor blockade on detrusor hyperreflexia induced by bacterial toxin in rats. Lecci, A., Tramontana, M., Giuliani, S., Criscuoli, M., Maggi, C.A. J. Urol. (1998) [Pubmed]
  27. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Mitsui, T., Fischer, I., Shumsky, J.S., Murray, M. Exp. Neurol. (2005) [Pubmed]
  28. Multiple spinal meningiomas--a case report. Lee, K.S., Cheang, C.M., Lieu, A.S., Howng, S.L. The Kaohsiung journal of medical sciences. (1999) [Pubmed]
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