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Gene Review

pol  - 

Moloney murine leukemia virus

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Disease relevance of pol


High impact information on pol

  • The mutants could be divided into two classes depending on the phenotype and map position of the deletion within the pol gene [6].
  • DNA sequence analysis of two SIRE-1 subclones revealed that SIRE-1 contains a long, uninterrupted, ORF between the 3' end of the pol ORF and the 3' long terminal repeat (LTR), a region that harbors the env gene in retroviral genomes [7].
  • The F6A provirus is organized into 5'-LTR-gag-pol-env-LTR-3' regions; the gag and pol open reading frames are separated by an amber codon, and env is in a different reading frame [8].
  • XC plaque assays of recombinant virus progeny on Fv-ln and Fv-lb cells indicated that the Fv-l host range was determined by sequences located between the BamHI site in the p30 region of the gag gene (1.6 kilobase pairs from the left end of the map) and the HindIII site located in the pol gene (2.9 kilobase pairs from the left end of the map) [9].
  • Although neither pol alpha nor KF readily polymerized a natural dNTP opposite either 5- or 6-nitrobenzimidazole in the template strand, the enzymes did incorporate the analogues to generate novel base pairs [10].

Biological context of pol


Analytical, diagnostic and therapeutic context of pol


  1. Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome. Reddy, E.P., Smith, M.J., Aaronson, S.A. Science (1981) [Pubmed]
  2. A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Donehower, L.A., Varmus, H.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Revealing Domain Structure through Linker-Scanning Analysis of the Murine Leukemia Virus (MuLV) RNase H and MuLV and Human Immunodeficiency Virus Type 1 Integrase Proteins. Puglia, J., Wang, T., Smith-Snyder, C., Cote, M., Scher, M., Pelletier, J.N., John, S., Jonsson, C.B., Roth, M.J. J. Virol. (2006) [Pubmed]
  4. Molecular characterization of the Akvr-1 restriction gene: a defective endogenous retrovirus-borne gene identical to Fv-4r. Dandekar, S., Rossitto, P., Pickett, S., Mockli, G., Bradshaw, H., Cardiff, R., Gardner, M. J. Virol. (1987) [Pubmed]
  5. Influence on stability in Escherichia coli of the carboxy-terminal structure of cloned Moloney murine leukemia virus reverse transcriptase. Gerard, G.F., D'Alessio, J.M., Kotewicz, M.L., Noon, M.C. DNA (1986) [Pubmed]
  6. Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: a new viral function required for productive infection. Schwartzberg, P., Colicelli, J., Goff, S.P. Cell (1984) [Pubmed]
  7. SIRE-1, a copia/Ty1-like retroelement from soybean, encodes a retroviral envelope-like protein. Laten, H.M., Majumdar, A., Gaucher, E.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Strong sequence conservation among horizontally transmissible, minimally pathogenic feline leukemia viruses. Donahue, P.R., Hoover, E.A., Beltz, G.A., Riedel, N., Hirsch, V.M., Overbaugh, J., Mullins, J.I. J. Virol. (1988) [Pubmed]
  9. Reversal of Fv-1 host range by in vitro restriction endonuclease fragment exchange between molecular clones of N-tropic and B-tropic murine leukemia virus genomes. Boone, L.R., Myer, F.E., Yang, D.M., Ou, C.Y., Koh, C.K., Roberson, L.E., Tennant, R.W., Yang, W.K. J. Virol. (1983) [Pubmed]
  10. Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I). Chiaramonte, M., Moore, C.L., Kincaid, K., Kuchta, R.D. Biochemistry (2003) [Pubmed]
  11. Functional analysis of reverse transcription by a frameshift pol mutant of murine leukemia virus. Messer, L.I., Currey, K.M., O'Neill, B.J., Maizel, J.V., Levin, J.G., Gerwin, B.I. Virology (1985) [Pubmed]
  12. Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. Weber, J., Weberova, J., Carobene, M., Mirza, M., Martinez-Picado, J., Kazanjian, P., Quiñones-Mateu, M.E. J. Virol. Methods (2006) [Pubmed]
  13. Molecular properties of a gag- pol- env+ murine leukemia virus from cultured AKR lymphoma cells. Rein, A., Lowy, D.R., Gerwin, B.I., Ruscetti, S.K., Bassin, R.H. J. Virol. (1982) [Pubmed]
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