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Gene Review

COX1  -  cytochrome c oxidase subunit 1

Kazachstania servazzii

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High impact information on COX1


Biological context of COX1


Anatomical context of COX1


Associations of COX1 with chemical compounds

  • To extend these observations, we examined the (R)- and (S)- enantiomers of RS- ketorolac, (S)- ketorolac exhibited potent COX1 and COX2 enzyme inhibition, whereas (R)- ketorolac was > 100-fold less active on both COX subtypes [8].

Other interactions of COX1


Analytical, diagnostic and therapeutic context of COX1


  1. Disruption of the yeast nuclear PET54 gene blocks excision of mitochondrial intron aI5 beta from pre-mRNA for cytochrome c oxidase subunit I. Valencik, M.L., Kloeckener-Gruissem, B., Poyton, R.O., McEwen, J.E. EMBO J. (1989) [Pubmed]
  2. Genetic evidence that different functional domains of the PET54 gene product facilitate expression of the mitochondrial genes COX1 and COX3 in Saccharomyces cerevisiae. Valencik, M.L., McEwen, J.E. Mol. Cell. Biol. (1991) [Pubmed]
  3. COX24 codes for a mitochondrial protein required for processing of the COX1 transcript. Barros, M.H., Myers, A.M., Van Driesche, S., Tzagoloff, A. J. Biol. Chem. (2006) [Pubmed]
  4. Initiation of transcription in yeast mitochondria: analysis of origins of replication and of genes coding for a messenger RNA and a transfer RNA. Osinga, K.A., De Vries, E., Van der Horst, G.T., Tabak, H.F. Nucleic Acids Res. (1984) [Pubmed]
  5. Expression of a continuous open reading frame encoding subunits 1 and 2 of cytochrome c oxidase in the mitochondrial DNA of Acanthamoeba castellanii. Lonergan, K.M., Gray, M.W. J. Mol. Biol. (1996) [Pubmed]
  6. The MSS51 gene product is required for the translation of the COX1 mRNA in yeast mitochondria. Decoster, E., Simon, M., Hatat, D., Faye, G. Mol. Gen. Genet. (1990) [Pubmed]
  7. A role for Pet100p in the assembly of yeast cytochrome c oxidase: interaction with a subassembly that accumulates in a pet100 mutant. Church, C., Goehring, B., Forsha, D., Wazny, P., Poyton, R.O. J. Biol. Chem. (2005) [Pubmed]
  8. Preclinical enantioselective pharmacology of (R)- and (S)- ketorolac. Handley, D.A., Cervoni, P., McCray, J.E., McCullough, J.R. Journal of clinical pharmacology. (1998) [Pubmed]
  9. Physical mapping and genome organization of mitochondrial DNA from Candida maltosa. Kunze, G., Bode, R., Birnbaum, D. Curr. Genet. (1986) [Pubmed]
  10. Cardioprotective effects of estradiol include the activation of large-conductance Ca(2+)-activated K(+) channels in cardiac mitochondria. Ohya, S., Kuwata, Y., Sakamoto, K., Muraki, K., Imaizumi, Y. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
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